desA1
- Type
- protein_coding
- Name
- desA1
- Locus Name
-
Rv0824c
- Product
-
Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des)
- Functional Category
-
Lipid metabolism
- Location
- 917734..918750 (- strand)
- Gene Length
- 1016 bp
- Nucleotides
-
ATGTCAGCCAAGCTGACCGACCTGCAGCTGCTGCACGAACTTGAACCGGTCGTCGAGAAGTACCTGAACCGGCACCTGAGCATGCACAAGCCCTGGAACCCGCACGACTACATCCCGTGGTCGGACGGGAAGAACTACTACGCGCTCGGCGGGCAGGATTGGGACCCCGACCAGAGCAAGCTTTCTGATGTCGCCCAGGTGGCGATGGTGCAGAACCTGGTCACCGAGGACAACCTGCCGTCGTATCACCGCGAGATCGCGATGAACATGGGCATGGACGGCGCGTGGGGGCAGTGGGTCAACCGTTGGACCGCCGAGGAGAATCGGCACGGCATCGCGCTGCGCGACTACCTGGTGGTGACCCGATCGGTCGACCCTGTCGAGTTGGAGAAACTTCGCCTCGAGGTAGTCAACCGGGGCTTCAGCCCAGGCCAAAACCACCAGGGCCACTATTTCGCGGAGAGCCTCACCGACTCCGTCCTCTATGTCAGTTTCCAGGAACTGGCAACCCGGATTTCGCACCGCAATACCGGCAAGGCATGTAACGACCCCGTCGCCGACCAGCTCATGGCCAAGATCTCGGCAGACGAGAATCTGCACATGATCTTCTACCGCGACGTCAGCGAGGCCGCGTTCGACCTCGTGCCCAACCAGGCCATGAAGTCGCTGCACCTGATTTTGAGCCACTTCCAGATGCCCGGCTTCCAAGTACCCGAGTTCCGGCGCAAAGCCGTGGTCATCGCCGTCGGGGGTGTCTACGACCCGCGCATCCACCTCGACGAAGTCGTCATGCCGGTACTGAAGAAATGGCGTATCTTCGAGCGCGAGGACTTCACCGGCGAGGGGGCTAAGCTGCGCGACGAGCTGGCCCTGGTGATCAAGGACCTCGAGCTGGCCTGCGACAAGTTCGAGGTGTCCAAGCAACGCCAACTCGACCGGGAAGCCCGTACGGGCAAGAAGGTCAGCGCACACGAGCTGCATAAAACCGCTGGCAAACTGGCGATGAGCCGTCGTTA
- Drug Resistance
- Mutations
- Function
- May be a desaturase involved in mycobacterial fatty acid biosynthesis. {ECO:0000305|PubMed:14559907}.
- Family
-
Fatty acid desaturase type 2 family
- GO
-
- metal ion binding GO:0046872 molecular_function
- cell surface GO:0009986 cellular_component
- cell wall GO:0005618 cellular_component
- cytosol GO:0005829 cellular_component
- acyl-[acyl-carrier-protein] desaturase activity GO:0045300 molecular_function
- response to host immune response GO:0052572 biological_process
- plasma membrane GO:0005886 cellular_component
- fatty acid biosynthetic process GO:0006633 biological_process
- InterPro
Summary
- Name
- Putative acyl-[acyl-carrier-protein] desaturase DesA1 (Putative acyl-ACP desaturase DesA1) (EC 1.14.19.-)
- Family
- Fatty acid desaturase type 2 family
- Protein Sequence
-
MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEFRRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR
- Mass
- 38,770 Da
- Length
- 338 Aa
Rv0824c doesn't seem to be a targeted by any drug.
-
-
Biosynthesis of unsaturated fatty acids mtu01040
mtu01040PATHWAY_MAP mtu01040 Biosynthesis of unsaturated fatty acids
-
-
-
Fatty acid biosynthesis mtu00061
mtu00061PATHWAY_MAP mtu00061 Fatty acid biosynthesis
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Unique mechanism of action of the thiourea drug isoxyl on Mycobacterium tuberculosis.
- J Biol Chem. 2003 Dec 26;278(52):53123-30. doi: 10.1074/jbc.M311209200. Epub 2003 Oct 14.
- Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv.
- Microbiology. 2002 Oct;148(Pt 10):2967-73. doi: 10.1099/00221287-148-10-2967.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
- Mycobacterium tuberculosis Des protein: an immunodominant target for the humoral response of tuberculous patients.
- Infect Immun. 1997 Jul;65(7):2883-9.