Rv0845
- Type
- protein_coding
- Name
- Rv0845
- Locus Name
-
Rv0845
- Product
-
Possible two component sensor kinase
- Functional Category
-
Regulatory proteins
- Location
- 941190..942467 (+ strand)
- Gene Length
- 1277 bp
- Nucleotides
-
TGCCCAGCTACGGCAACCTCGGACGTTTGGGCGGTCGCCATGAGTACGGTGTCCTAGTGGCAATGACCAGCTCGGCGGAACTGGACCGGGTTCGTTGGGCGCACCAGTTGCGCTCCTACCGAATTGCTTCGGTATTGCGGATCGGTGTCGTGGGGCTCATGGTCGCCGCGATGGTCGTTGGAACCAGCCGGTCCGAATGGCCACAGCAAATCGTGTTGATCGGCGTCTACGCGGTCGCTGCATTGTGGGCTCTGCTGTTAGCGTATTCGGCGTCCCGGCGATTCTTCGCTTTGCGACGCTTTCGCAGTATGGGCCGGTTGGAGCCATTTGCTTTCACCGCCGTCGACGTTTTGATATTGACGGGCTTTCAGCTGCTGTCCACCGACGGGATCTATCCGCTGCTGATCATGATCCTGCTGCCGGTCCTGGTGGGCCTTGACGTGTCGACGCGACGGGCGGCGGTGGTGCTGGCCTGTACGCTAGTCGGATTCGCAGTCGCGGTGCTGGGAGACCCCGTGATGCTGCGCGCGATTGGATGGCCCGAGACAATATTTCGGTTCGCGCTCTATGCGTTCCTGTGCGCCACGGCCTTGATGGTGGTTCGCATCGAGGAGCGGCATACCCGTTCGGTTGCCGGCCTGAGTGCGTTGCGGGCGGAACTGCTTGCCCAGACGATGACGGCCTCGGAGGTGCTGCAGCGGCGGATTGCGGAAGCCATTCACGATGGACCGCTGCAAGACGTGCTGGCCGCGCGTCAGGAGCTCATCGAGTTGGATGCCGTAACCCCCGGCGACGAGCGCGTCGGACGCGCGTTGGCCGGACTGCAGAGCGCGTCGGAGCGGCTGCGGCAGGCCACCTTCGAGCTGCATCCGGCAGTGCTTGAGCAAGTTGGGTTGGGGCCGGCGGTAAAACAGTTGGCGGCCTCTACCGCTCAGCGTTCGGGTATCAAGATCTCCACCGATATTGATTACCCAATACGTAGTGGGATCGACCCCATCGTTTTCGGTGTGGTTCGCGAACTGCTGTCCAACGTCGTGCGGCATTCCGGAGCTACCACCGCCTCGGTCAGGCTCGGAATCACCGACGAAAAATGCGTTTTGGATGTGGCCGACGATGGCGTGGGGGTCACCGGTGACACTATGGCGCGCCGCCTGGGTGAGGGACACATCGGTCTGGCTTCGCATCGGGCTCGGGTGGATGCCGCCGGCGGAGTTTTGGTTTTCCTGGCCACCCCCAGGGGGACCCATGTCTGCGTGGAACTACCACTGAAACGGTGA
- Drug Resistance
- Mutations
- Function
- Probable member of the two-component regulatory system NarS/NarL. May activate NarL by phosphorylation. {ECO:0000269|PubMed:12595424}.
- Family
-
Unknown
- GO
-
- plasma membrane GO:0005886 cellular_component
- phosphorelay signal transduction system GO:0000160 biological_process
- protein histidine kinase activity GO:0004673 molecular_function
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Probable sensor histidine kinase NarS (EC 2.7.13.3)
- Family
- Unknown
- Protein Sequence
-
MPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACTLVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTHVCVELPLKR
- Mass
- 45,784 Da
- Length
- 425 Aa
Rv0845 doesn't seem to be a targeted by any drug.
Rv0845 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis.
- Infect Immun. 2003 Mar;71(3):1134-40. doi: 10.1128/iai.71.3.1134-1140.2003.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.