Gene - combatTB X

fadB

Type: protein_coding
Name: fadB
Locus Name: Rv0860
Product: Probable fatty oxidation protein FadB
Functional Category: Lipid metabolism
Location: 956293..958455 (+ strand)
Gene Length: 2162 bp
Nucleotides: TGCCAGACAACACAATCCAGTGGGACAAGGATGCCGACGGCATCGTCACGCTGACCATGGACGATCCCTCCGGGTCAACCAACGTGATGAACGAGGCCTACATCGAGTCGATGGGCAAGGCCGTCGATCGCCTTGTCGCCGAAAAGGATTCGATCACCGGAGTGGTAGTCGCCAGCGCGAAGAAAACCTTCTTCGCCGGCGGCGACGTCAAGACGATGATCCAGGCCAGGCCCGAGGACGCCGGCGATGTATTCAACACCGTCGAGACCATCAAGCGGCAGCTGCGCACCTTGGAGACATTGGGTAAGCCGGTCGTCGCGGCCATCAACGGGGCGGCGTTGGGCGGCGGCCTGGAGATCGCGCTGGCGTGTCATCACCGGATCGCCGCCGACGTCAAGGGCAGCCAGCTCGGTCTGCCGGAGGTGACGCTGGGTCTGCTGCCGGGTGGCGGTGGGGTGACCCGCACGGTACGGATGTTCGGCATCCAGAACGCGTTCGTGAGCGTGCTGGCGCAAGGTACCCGGTTCAAGCCGGCCAAGGCCAAGGAGATCGGTCTGGTCGACGAGCTGGTGGCAACGGTCGAGGAGCTGGTGCCCGCCGCCAAGGCTTGGATAAAGGAGGAGCTCAAGGCCAACCCCGACGGTGCCGGGGTGCAGCCGTGGGACAAGAAGGGCTACAAGATGCCCGGCGGCACCCCGTCGTCGCCGGGTCTGGCGGCGATTTTGCCGTCGTTCCCGTCGAACCTGCGCAAGCAGCTCAAGGGTGCCCCGATGCCGGCGCCGCGGGCCATCCTGGCCGCCGCGGTCGAGGGGGCACAGGTCGATTTCGACACCGCCAGCCGCATCGAGAGCCGCTACTTCGCGTCGTTGGTCACCGGCCAGGTCGCCAAGAACATGATGCAGGCGTTCTTCTTCGACCTGCAGGCCATCAATGCCGGCGGGTCTCGGCCCGAAGGCATCGGCAAGACCCCGATCAAGAGGATCGGTGTGCTGGGTGCGGGCATGATGGGCGCCGGCATCGCCTACGTCTCTGCCAAGGCCGGCTATGAGGTGGTACTCAAAGATGTCAGCCTTGAGGCCGCCGCTAAAGGCAAGGGCTACTCCGAAAAGCTGGAGGCCAAGGCGCTGGAGCGGGGCCGCACCACACAGGAGCGCAGCGACGCCCTGCTGGCGCGCATCACCCCGACCGCCGACGCCGCCGATTTCAAGGGCGTTGATTTCGTGATCGAGGCGGTTTTTGAAAACCAGGAGCTCAAGCACAAGGTGTTCGGCGAGATCGAAGACATCGTCGAGCCCAACGCGATCCTGGGATCCAACACCTCGACGCTGCCGATCACCGGTCTGGCGACCGGCGTCAAGCGGCAGGAAGACTTTATCGGGATCCACTTCTTCTCGCCGGTCGACAAGATGCCGCTGGTGGAGATCATCAAGGGCGAGAAGACTTCTGACGAGGCCCTGGCCCGGGTGTTCGACTACACCTTGGCCATCGGCAAGACCCCGATCGTGGTCAACGACAGCCGCGGCTTTTTCACCTCGCGGGTCATCGGCACGTTCGTCAACGAGGCGCTGGCGATGCTCGGTGAGGGTGTCGAGCCGGCTTCTATCGAGCAGGCGGGGTCGCAGGCCGGGTATCCGGCGCCGCCGCTGCAGCTGTCCGACGAGCTCAACTTGGAGCTGATGCACAAGATCGCCGTCGCCACCCGTAAGGGTGTTGAGGACGCCGGCGGCACGTACCAGCCGCATCCGGCGGAGGCCGTGGTGGAGAAGATGATCGAGCTCGGCCGGTCCGGCCGGCTGAAGGGCGCGGGCTTCTACGAGTACGCCGACGGCAAGCGATCCGGGTTGTGGCCCGGCTTGCGCGAGACGTTCAAGTCGGGCTCGTCGCAGCCGCCGCTGCAGGACATGATCGACCGCATGCTGTTCGCCGAGGCGCTGGAAACCCAGAAGTGCCTCGACGAGGGGGTGCTGACGTCGACGGCCGACGCCAACATCGGCTCGATCATGGGCATCGGCTTCCCGCCGTGGACAGGTGGCAGTGCCCAGTTCATCGTCGGCTACTCCGGCCCGGCCGGTACCGGTAAGGCGGCTTTCGTGGCCCGGGCCCGCGAGCTGGCGGCCGCCTACGGCGACCGCTTCCTGCCGCCGGAGTCGCTGCTAAGCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
nucleotide binding GO:0000166 molecular_function
enoyl-CoA hydratase activity GO:0004300 molecular_function
long-chain-3-hydroxyacyl-CoA dehydrogenase activity GO:0016509 molecular_function
fatty acid beta-oxidation GO:0006635 biological_process

InterPro

UniProt: O53872
GenBank: Rv0860
EnsemblBacteria: Rv0860
Mycobrowser: Rv0860

Summary

Name: Probable fatty oxidation protein FadB
Family: Unknown
Protein Sequence: MPDNTIQWDKDADGIVTLTMDDPSGSTNVMNEAYIESMGKAVDRLVAEKDSITGVVVASAKKTFFAGGDVKTMIQARPEDAGDVFNTVETIKRQLRTLETLGKPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPEVTLGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTRFKPAKAKEIGLVDELVATVEELVPAAKAWIKEELKANPDGAGVQPWDKKGYKMPGGTPSSPGLAAILPSFPSNLRKQLKGAPMPAPRAILAAAVEGAQVDFDTASRIESRYFASLVTGQVAKNMMQAFFFDLQAINAGGSRPEGIGKTPIKRIGVLGAGMMGAGIAYVSAKAGYEVVLKDVSLEAAAKGKGYSEKLEAKALERGRTTQERSDALLARITPTADAADFKGVDFVIEAVFENQELKHKVFGEIEDIVEPNAILGSNTSTLPITGLATGVKRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYTLAIGKTPIVVNDSRGFFTSRVIGTFVNEALAMLGEGVEPASIEQAGSQAGYPAPPLQLSDELNLELMHKIAVATRKGVEDAGGTYQPHPAEAVVEKMIELGRSGRLKGAGFYEYADGKRSGLWPGLRETFKSGSSQPPLQDMIDRMLFAEALETQKCLDEGVLTSTADANIGSIMGIGFPPWTGGSAQFIVGYSGPAGTGKAAFVARARELAAAYGDRFLPPESLLS
Mass: 76,104 Da
Length: 720 Aa

Rv0860 doesn't seem to be a targeted by any drug.

Limonene and pinene degradation mtu00903
mtu00903
PATHWAY_MAP mtu00903 Limonene and pinene degradation

Butanoate metabolism mtu00650
mtu00650
PATHWAY_MAP mtu00650 Butanoate metabolism

Propanoate metabolism mtu00640
mtu00640
PATHWAY_MAP mtu00640 Propanoate metabolism

beta-Alanine metabolism mtu00410
mtu00410
PATHWAY_MAP mtu00410 beta-Alanine metabolism

Tryptophan metabolism mtu00380
mtu00380
PATHWAY_MAP mtu00380 Tryptophan metabolism

Benzoate degradation mtu00362
mtu00362
PATHWAY_MAP mtu00362 Benzoate degradation

Lysine degradation mtu00310
mtu00310
PATHWAY_MAP mtu00310 Lysine degradation

Valine, leucine and isoleucine degradation mtu00280
mtu00280
PATHWAY_MAP mtu00280 Valine, leucine and isoleucine degradation

Fatty acid degradation mtu00071
mtu00071
PATHWAY_MAP mtu00071 Fatty acid degradation

Structure of mycobacterial beta-oxidation trifunctional enzyme reveals its altered assembly and putative substrate channeling pathway.: ACS Chem Biol. 2013 May 17;8(5):1063-73. doi: 10.1021/cb400007k. Epub 2013 Mar 27.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.