Rv0888
- Type
- protein_coding
- Name
- Rv0888
- Locus Name
-
Rv0888
- Product
-
Probable exported protein
- Functional Category
-
Cell wall and cell processes
- Location
- 987233..988705 (+ strand)
- Gene Length
- 1472 bp
- Nucleotides
-
TGGATTACGCCAAACGCATCGGCCAGGTTGGGGCGTTAGCCGTTGTCCTGGGGGTGGGGGCGGCGGTGACTACCCACGCGATCGGCTCTGCCGCGCCGACGGATCCGAGCTCCTCGAGCACCGATTCGCCGGTCGACGCGTGCTCGCCGTTGGGTGGGTCCGCCAGTTCGTTGGCTGCGATACCGGGCGCCAGTGTGCCACAGGTCGGCGTGCGACAGGTAGACCCCGGAAGCATCCCCGATGACTTGCTCAATGCCCTGATCGACTTTCTGGCCGCGGTACGCAACGGGTTGGTGCCCATCATCGAAAACCGCACTCCGGTAGCGAATCCGCAACAAGTCAGCGTCCCTGAGGGGGGCACCGTCGGCCCGGTCCGGTTTGACGCCTGCGACCCCGATGGCAACCGGATGACCTTCGCGGTGCGCGAGCGCGGTGCACCCGGTGGACCCCAGCATGGCATCGTGACCGTCGACCAACGAACGGCCAGCTTCATCTACACAGCCGATCCGGGTTTCGTTGGCACCGATACCTTCAGTGTGAACGTCAGCGATGACACCAGCCTGCACGTGCACGGTCTGGCGGGATACCTGGGTCCGTTCCATGGGCACGACGACGTCGCCACCGTGACCGTGTTCGTCGGCAACACCCCGACCGACACCATCAGCGGCGACTTCAGCATGCTCACCTACAACATCGCGGGGCTGCCCTTCCCGCTATCCAGCGCAATTCTGCCCCGGTTCTTCTACACCAAAGAGATTGGGAAGCGGCTCAACGCCTACTACGTCGCGAACGTCCAGGAGGATTTCGCCTACCACCAATTCCTCATCAAGAAATCCAAGATGCCCAGCCAGACCCCGCCGGAGCCGCCTACCTTGCTGTGGCCTATCGGTGTGCCCTTCTCCGACGGGCTCAATACCCTCTCGGAGTTCAAGGTGCAGCGGCTGGACCGGCAGACATGGTATGAGTGCACATCCGACAACTGCCTCACCTTGAAGGGCTTCACCTACAGCCAGATGCGGCTTCCCGGCGGTGACACGGTCGACGTCTACAACTTACATACCAACACCGGTGGAGGGCCGACCACCAACGCCAACCTCGCGCAGGTCGCCAACTACATCCAGCAGAACTCGGCGGGCCGCGCGGTCATCGTCACCGGCGACTTCAACGCGCGGTACTCCGACGACCAAAGCGCTCTGTTGCAATTTGCGCAGGTCAACGGGCTCACCGATGCCTGGGTGCAGGTAGAACACGGCCCCACCACACCGCCGTTCGCGCCCACTTGCATGGTCGGCAACGAGTGCGAGCTGCTCGACAAGATCTTCTATCGAAGCGGCCAGGGAGTGACGTTGCAGGCCGTCAGCTACGGCAACGAGGCGCCGAAATTCTTCAATTCCAAGGGTGAGCCACTGTCGGATCACAGCCCGGCGGTGGTCGGCTTCCACTACGTCGCGGACAACGTGGCCGTACGGTGA
- Drug Resistance
- Mutations
- Function
- Catalyzes the cleavage of sphingomyelin, a major lipid in eukaryotic cells, into ceramide and phosphocholine, which are then utilized by M.tuberculosis as carbon, nitrogen and phosphorus sources, respectively. Thus, enables M.tuberculosis to utilize sphingomyelin as a source of several essential nutrients for intracellular growth during infection. Furthermore, lyses erythrocytes and constitutes the main hemolytic factor of M.tuberculosis. {ECO:0000269|PubMed:26036301}.
- Family
-
SpmT family
- GO
-
- pore complex GO:0046930 cellular_component
- hemolysis in other organism GO:0044179 biological_process
- organic substance transport GO:0071702 biological_process
- neutral sphingomyelin phosphodiesterase activity GO:0061751 molecular_function
- cellular response to lipid GO:0071396 biological_process
- cell outer membrane GO:0009279 cellular_component
- transporter activity GO:0005215 molecular_function
- porin activity GO:0015288 molecular_function
- ion transport GO:0006811 biological_process
- sphingomyelin catabolic process GO:0006685 biological_process
- InterPro
Summary
- Name
- Sphingomyelinase (SMase) (EC 3.1.4.12)
- Family
- SpmT family
- Protein Sequence
-
MDYAKRIGQVGALAVVLGVGAAVTTHAIGSAAPTDPSSSSTDSPVDACSPLGGSASSLAAIPGASVPQVGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVPEGGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTADPGFVGTDTFSVNVSDDTSLHVHGLAGYLGPFHGHDDVATVTVFVGNTPTDTISGDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAYYVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPFSDGLNTLSEFKVQRLDRQTWYECTSDNCLTLKGFTYSQMRLPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVTGDFNARYSDDQSALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKIFYRSGQGVTLQAVSYGNEAPKFFNSKGEPLSDHSPAVVGFHYVADNVAVR
- Mass
- 52,034 Da
- Length
- 490 Aa
Rv0888 doesn't seem to be a targeted by any drug.
Rv0888 doesn't seem to be involved in any pathway.
- Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.
- Mol Microbiol. 2015 Sep;97(5):881-97. doi: 10.1111/mmi.13073. Epub 2015 Jul 4.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.