Gene - combatTB X

prrB

Type: protein_coding
Name: prrB
Locus Name: Rv0902c
Product: Two component sensor histidine kinase PrrB
Functional Category: Regulatory proteins
Location: 1004501..1005841 (- strand)
Gene Length: 1340 bp
Nucleotides: ATGAATATTCTGTCGCGGATCTTCGCCCGTACGCCCTCGCTGCGAACCCGGGTGGTGGTCGCGACGGCGATCGGCGCCGCGATCCCGGTACTCATTGTCGGCACCGTCGTCTGGGTCGGGATCACCAACGACCGCAAGGAGCGGCTGGACCGCCGGCTCGACGAGGCCGCGGGTTTCGCGATCCCGTTCGTGCCGCGTGGCCTCGACGAGATCCCGCGCTCACCGAACGACCAGGACGCCCTCATCACGGTCCGCCGTGGCAACGTGATCAAGTCGAATTCCGACATCACGCTGCCCAAACTGCAAGACGACTACGCCGACACCTACGTCCGCGGGGTGCGCTACCGCGTGCGCACGGTGGAGATCCCCGGGCCCGAGCCGACGTCGGTGGCGGTGGGCGCGACGTATGACGCCACCGTAGCCGAGACCAACAACCTGCACCGCCGGGTGCTGCTGATCTGTACCTTCGCCATCGGCGCGGCGGCGGTGTTCGCCTGGCTGTTGGCCGCGTTCGCGGTACGCCCGTTCAAGCAGCTCGCCGAGCAGACCCGGTCCATCGACGCGGGCGACGAGGCGCCACGCGTGGAAGTACACGGCGCCAGCGAAGCCATCGAGATCGCCGAGGCGATGCGCGGCATGCTGCAGCGCATCTGGAACGAGCAGAACCGAACCAAGGAGGCGCTTGCGTCGGCGCGTGACTTCGCGGCGGTGTCCTCCCACGAGCTGCGCACTCCGCTGACCGCGATGCGCACCAACCTGGAGGTGCTGTCCACCCTGGATCTGCCCGACGACCAGCGCAAAGAAGTGCTCAACGACGTCATCCGCACCCAGTCGCGCATTGAGGCCACCCTGAGCGCGCTGGAGCGGTTGGCCCAGGGCGAACTGTCGACCTCGGACGATCACGTGCCGGTCGATATCACCGACCTGCTCGACCGCGCCGCCCACGACGCGGCCCGGATCTACCCCGATCTCGATGTATCGCTGGTGCCGTCGCCGACCTGCATCATCGTGGGTTTGCCGGCCGGGTTGCGCCTGGCCGTCGACAACGCCATCGCCAACGCGGTCAAGCACGGCGGCGCCACCCTGGTTCAACTCTCCGCGGTCAGCTCGCGGGCCGGCGTGGAGATCGCCATCGACGACAACGGCAGCGGAGTGCCCGAAGGTGAGCGCCAAGTGGTGTTCGAGCGGTTCTCCCGCGGGTCCACGGCATCTCATTCGGGGTCGGGTCTCGGGCTGGCGTTGGTGGCCCAACAGGCCCAGTTGCACGGCGGCACCGCGTCGCTGGAGAACAGCCCGCTGGGTGGCGCGCGCCTCGTGTTGCGCCTTCCCGGGCCCAGTTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Member of the two-component regulatory system PrrB/PrrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates PrrA. {ECO:0000269|PubMed:11953357}.

Family

Unknown

GO

protein autophosphorylation GO:0046777 biological_process
growth involved in symbiotic interaction GO:0044110 biological_process
cell wall GO:0005618 cellular_component
ATP binding GO:0005524 molecular_function
identical protein binding GO:0042802 molecular_function
integral component of plasma membrane GO:0005887 cellular_component
phosphorelay sensor kinase activity GO:0000155 molecular_function
protein kinase activity GO:0004672 molecular_function

InterPro

UniProt: P9WGK7
GenBank: Rv0902c
EnsemblBacteria: Rv0902c
Mycobrowser: Rv0902c

Summary

Name: Sensor-type histidine kinase PrrB (EC 2.7.13.3)
Family: Unknown
Protein Sequence: MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFVPRGLDEIPRSPNDQDALITVRRGNVIKSNSDITLPKLQDDYADTYVRGVRYRVRTVEIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAVFAWLLAAFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIWNEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVLNDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAARIYPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAVSSRAGVEIAIDDNGSGVPEGERQVVFERFSRGSTASHSGSGLGLALVAQQAQLHGGTASLENSPLGGARLVLRLPGPS
Mass: 47,829 Da
Length: 446 Aa

Rv0902c doesn't seem to be a targeted by any drug.

Two-component system mtu02020
mtu02020
Environmental Information Processing; Signal transduction

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis.: Infect Immun. 2002 May;70(5):2256-63. doi: 10.1128/iai.70.5.2256-2263.2002.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.