Gene - combatTB X

accD3

Type: protein_coding
Name: accD3
Locus Name: Rv0904c
Product: Putative acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) AccD3 (accase beta chain)
Functional Category: Lipid metabolism
Location: 1006693..1008180 (- strand)
Gene Length: 1487 bp
Nucleotides: GTGAGTCGTATCACGACCGACCAACTGCGGCACGCGGTGCTAGACCGGGGATCTTTCGTCAGCTGGGATAGCGAGCCGCTGGCGGTGCCGGTAGCCGACTCCTATGCGCGGGAGCTGGCCGCCGCTCGGGCGGCCACCGGCGCGGACGAATCGGTGCAGACCGGTGAGGGACGCGTATTCGGGCGGCGGGTGGCCGTGGTGGCCTGTGAGTTCGACTTCCTGGGCGGCTCGATTGGGGTGGCAGCGGCCGAACGGATCACCGCCGCCGTCGAGCGGGCGACCGCCGAGCGGCTGCCGCTACTGGCGTCACCAAGCTCGGGAGGCACCCGCATGCAAGAAGGCACGGTCGCGTTTCTGCAGATGGTGAAGATCGCTGCGGCCATCCAGCTGCACAACCAGGCGCGCCTGCCCTACCTGGTCTATTTGCGCCATCCGACCACGGGTGGAGTTTTCGCGTCGTGGGGCTCGCTGGGGCATCTCACCGTCGCCGAGCCGGGCGCCCTGATCGGCTTTCTGGGACCACGGGTCTATGAGTTGCTCTATGGCGACCCCTTCCCATCCGGCGTCCAAACCGCCGAGAATCTACGGCGGCATGGGATCATCGACGGCGTCGTTGCACTGGACCGGCTACGACCGATGCTGGATCGTGCGTTGACGGTGCTCATCGACGCTCCCGAACCGCTTCCGGCACCGCAGACGCCCGCGCCCGTACCCGATGTGCCCACGTGGGACTCGGTGGTGGCATCGCGCCGGCCGGACCGGCCGGGCGTCAGGCAGCTACTGCGACACGGCGCCACCGACCGGGTGTTGTTGTCAGGAACCGATCAAGGCGAAGCGGCGACCACGCTGCTGGCGCTGGCCCGCTTTGGCGGCCAACCCACGGTGGTCCTCGGCCAGCAAAGGGCAGTAGGCGGCGGGGGAAGCACTGTCGGGCCCGCTGCGTTACGCGAAGCCCGACGCGGGATGGCGCTCGCCGCCGAGCTGTGCCTGCCGCTGGTGCTGGTCATTGACGCGGCCGGACCCGCGTTGTCGGCCGCAGCCGAACAGGGCGGGCTGGCCGGCCAGATCGCGCATTGCCTGGCCGAGCTCGTCACGCTGGATACCCCGACCGTGTCGATCCTGCTGGGCCAGGGCAGCGGCGGGCCGGCGCTGGCGATGTTGCCCGCCGACCGGGTGCTGGCCGCACTCCACGGCTGGCTGGCGCCCTTGCCTCCCGAAGGAGCCAGCGCGATCGTGTTCCGAGACACTGCTCATGCCGCCGAACTCGCTGCCGCCCAAGGCATCCGGTCGGCCGACCTACTGAAGTCGGGGATTGTCGACACCATCGTGCCGGAGTACCCCGACGCCGCAGACGAGCCGATCGAGTTCGCCCTACGACTGTCGAACGCCATCGCCGCCGAAGTGCACGCGTTACGGAAGATACCGGCCCCGGAACGCCTCGCGACTCGGTTGCAACGCTACCGCCGGATCGGGTTGCCCCGCGACTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. {ECO:0000250}.

Family

AccD/PCCB family

GO

mycolic acid biosynthetic process GO:0071768 biological_process
acetyl-CoA carboxylase complex GO:0009317 cellular_component
acetyl-CoA carboxylase activity GO:0003989 molecular_function
ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component

InterPro

UniProt: P9WQH9
GenBank: Rv0904c
EnsemblBacteria: Rv0904c
Mycobrowser: Rv0904c

Summary

Name: Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase beta chain) (EC 6.4.1.2)
Family: AccD/PCCB family
Protein Sequence: MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDVPTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGLPRD
Mass: 51,772 Da
Length: 495 Aa

Rv0904c doesn't seem to be a targeted by any drug.

Propanoate metabolism mtu00640
mtu00640
PATHWAY_MAP mtu00640 Propanoate metabolism

Pyruvate metabolism mtu00620
mtu00620
PATHWAY_MAP mtu00620 Pyruvate metabolism

Fatty acid biosynthesis mtu00061
mtu00061
PATHWAY_MAP mtu00061 Fatty acid biosynthesis

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Genes required for mycobacterial growth defined by high density mutagenesis.: Mol Microbiol. 2003 Apr;48(1):77-84.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.