Gene - combatTB X

pstC2

Type: protein_coding
Name: pstC2
Locus Name: Rv0929
Product: Phosphate-transport integral membrane ABC transporter PstC2
Functional Category: Cell wall and cell processes
Location: 1036028..1037002 (+ strand)
Gene Length: 974 bp
Nucleotides: TGGTCACCGAGCCGCTCACAAAGCCGGCGCTAGTGGCGGTCGACATGCGCCCCGCGCGGCGCGGCGAGCGGCTGTTCAAGCTGGCCGCGTCGGCCGCCGGTTCGACGATCGTCATCGCAATCCTGCTGATCGCGATATTCCTGTTGGTCCGCGCCGTGCCGTCGTTGCGGGCGAATCACGCCAATTTCTTCACCAGTACCCAATTCGACACGTCGGACGATGAGCAGCTGGCGTTTGGTGTCCGGGACTTGTTCATGGTCACGGCGTTGAGTTCGATAACGGCTCTGGTGTTGGCGGTGCCGGTGGCTGTCGGGATCGCGGTGTTCCTCACCCACTACGCGCCGAGGAGACTGTCGCGTCCATTCGGCGCGATGGTGGATCTACTGGCCGCAGTGCCGTCGATCATCTTCGGGTTGTGGGGGATCTTTGTGCTGGCGCCCAAGCTCGAGCCGATCGCGAGGTTTCTCAATCGCAACTTGGGCTGGTTGTTCCTGTTTAAGCAGGGCAACGTGTCGTTGGCCGGCGGCGGCACGATTTTCACCGCGGGCATCGTGCTGTCGGTGATGATCCTGCCTATCGTCACATCGATATCACGCGAAGTGTTCCGGCAGACTCCGCTGATCCAAATCGAAGCAGCGCTGGCGCTAGGCGCGACGAAATGGGAGGTAGTGCGGATGACCGTGCTGCCATACGGGCGAAGCGGGGTGGTCGCGGCCTCCATGCTGGGTTTGGGGCGGGCTCTGGGCGAAACCGTGGCCGTGCTGGTCATCCTGCGCTCGGCCGCGCGGCCGGGGACCTGGTCGCTGTTCGACGGCGGTTATACGTTCGCTTCCAAGATCGCCTCCGCTGCTTCAGAATTCAGCGAACCGCTGCCGACCGGAGCCTATATTTCGGCGGGATTTGCGTTATTCGTGCTGACGTTCCTGGTCAATGCGGCCGCTCGCGCAATCGCCGGCGGGAAGGTCAACGGGTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate across the membrane. {ECO:0000305|PubMed:20933472}.

Family

Binding-protein-dependent transport system permease family, CysTW subfamily

GO

growth of symbiont in host GO:0044117 biological_process
inorganic phosphate transmembrane transporter activity GO:0005315 molecular_function
plasma membrane GO:0005886 cellular_component
phosphate ion transport GO:0006817 biological_process
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WG05
GenBank: Rv0929
EnsemblBacteria: Rv0929
Mycobrowser: Rv0929

Summary

Name: Phosphate transport system permease protein PstC 2
Family: Binding-protein-dependent transport system permease family, CysTW subfamily
Protein Sequence: MVTEPLTKPALVAVDMRPARRGERLFKLAASAAGSTIVIAILLIAIFLLVRAVPSLRANHANFFTSTQFDTSDDEQLAFGVRDLFMVTALSSITALVLAVPVAVGIAVFLTHYAPRRLSRPFGAMVDLLAAVPSIIFGLWGIFVLAPKLEPIARFLNRNLGWLFLFKQGNVSLAGGGTIFTAGIVLSVMILPIVTSISREVFRQTPLIQIEAALALGATKWEVVRMTVLPYGRSGVVAASMLGLGRALGETVAVLVILRSAARPGTWSLFDGGYTFASKIASAASEFSEPLPTGAYISAGFALFVLTFLVNAAARAIAGGKVNG
Mass: 34,262 Da
Length: 324 Aa

Rv0929 doesn't seem to be a targeted by any drug.

ABC transporters mtu02010
mtu02010
Environmental Information Processing; Membrane transport

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.: Tuberculosis (Edinb). 2010 Nov;90(6):338-45. doi: 10.1016/j.tube.2010.09.004. Epub 2010 Oct 8.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter.: FEBS Lett. 1996 Sep 30;394(2):206-12.