pstS2
- Type
- protein_coding
- Name
- pstS2
- Locus Name
-
Rv0932c
- Product
-
Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2)
- Functional Category
-
Cell wall and cell processes
- Location
- 1039936..1041048 (- strand)
- Gene Length
- 1112 bp
- Nucleotides
-
GTGAAGTTCGCCCGATCCGGCGCAGCGGTAAGCCTGTTGGCCGCCGGCACACTGGTGTTGACAGCATGCGGCGGTGGCACCAACAGCTCGTCGTCAGGCGCAGGCGGCACGTCTGGGTCGGTGCACTGCGGCGGCAAGAAGGAGCTCCACTCCAGCGGCTCGACCGCACAAGAAAATGCCATGGAGCAGTTCGTCTATGCCTACGTGCGATCGTGCCCGGGCTACACGTTGGACTACAACGCCAACGGGTCCGGTGCCGGGGTGACCCAGTTTCTCAACAACGAAACCGATTTCGCCGGCTCGGATGTCCCGTTGAATCCGTCGACCGGTCAACCTGACCGGTCGGCGGAGCGGTGCGGTTCCCCGGCATGGGACCTGCCGACGGTGTTCGGCCCGATCGCGATCACCTACAATATCAAGGGCGTGAGCACGCTGAATCTTGACGGACCCACTACCGCCAAGATTTTCAACGGCACCATCACCGTGTGGAATGATCCACAGATCCAAGCCCTCAACTCCGGCACCGACCTGCCGCCAACACCGATTAGCGTTATCTTCCGCAGCGACAAGTCCGGTACGTCGGACAACTTCCAGAAATACCTCGACGGCGCATCCAACGGGGCGTGGGGCAAAGGCGCCAGCGAAACGTTCAACGGGGGCGTCGGCGTCGGCGCCAGCGGGAACAACGGCACGTCGGCCCTACTGCAGACGACCGACGGGTCGATCACCTACAACGAGTGGTCGTTTGCGGTGGGTAAGCAGTTGAACATGGCCCAGATCATCACGTCGGCGGGTCCGGATCCAGTGGCGATCACCACCGAGTCGGTCGGCAAGACAATCGCCGGGGCCAAGATCATGGGACAAGGCAACGACCTGGTATTGGACACGTCGTCGTTCTACAGGCCCACCCAGCCTGGCTCTTACCCGATCGTGCTGGCGACCTATGAGATCGTCTGCTCGAAATACCCGGATGCGACGACCGGTACTGCGGTAAGGGCGTTTATGCAAGCCGCGATTGGTCCAGGCCAAGAAGGCCTGGACCAATACGGCTCCATTCCGTTGCCCAAATCGTTCCAAGCAAAATTGGCGGCCGCGGTGAATGCTATTTCTTG
- Drug Resistance
- Mutations
- Function
- Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation (PubMed:15731097, PubMed:20933472). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). {ECO:0000269|PubMed:15731097, ECO:0000269|PubMed:20933472, ECO:0000305}.
- Family
-
PstS family
- GO
-
- pathogenesis GO:0009405 biological_process
- phosphate ion binding GO:0042301 molecular_function
- extracellular region GO:0005576 cellular_component
- phosphate ion transmembrane transport GO:0035435 biological_process
- ATP-binding cassette (ABC) transporter complex GO:0043190 cellular_component
- plasma membrane GO:0005886 cellular_component
- phosphate ion transport GO:0006817 biological_process
- InterPro
Summary
- Name
- Phosphate-binding protein PstS 2 (PBP 2) (PstS-2)
- Family
- PstS family
- Protein Sequence
-
MKFARSGAAVSLLAAGTLVLTACGGGTNSSSSGAGGTSGSVHCGGKKELHSSGSTAQENAMEQFVYAYVRSCPGYTLDYNANGSGAGVTQFLNNETDFAGSDVPLNPSTGQPDRSAERCGSPAWDLPTVFGPIAITYNIKGVSTLNLDGPTTAKIFNGTITVWNDPQIQALNSGTDLPPTPISVIFRSDKSGTSDNFQKYLDGASNGAWGKGASETFNGGVGVGASGNNGTSALLQTTDGSITYNEWSFAVGKQLNMAQIITSAGPDPVAITTESVGKTIAGAKIMGQGNDLVLDTSSFYRPTQPGSYPIVLATYEIVCSKYPDATTGTAVRAFMQAAIGPGQEGLDQYGSIPLPKSFQAKLAAAVNAIS
- Mass
- 37,864 Da
- Length
- 370 Aa
Rv0932c doesn't seem to be a targeted by any drug.
-
-
Tuberculosis mtu05152
mtu05152Human Diseases; Infectious disease: bacterial
-
-
-
Two-component system mtu02020
mtu02020Environmental Information Processing; Signal transduction
-
-
-
ABC transporters mtu02010
mtu02010Environmental Information Processing; Membrane transport
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.
- Tuberculosis (Edinb). 2010 Nov;90(6):338-45. doi: 10.1016/j.tube.2010.09.004. Epub 2010 Oct 8.
- Mycobacterium tuberculosis with disruption in genes encoding the phosphate binding proteins PstS1 and PstS2 is deficient in phosphate uptake and demonstrates reduced in vivo virulence.
- Infect Immun. 2005 Mar;73(3):1898-902. doi: 10.1128/IAI.73.3.1898-1902.2005.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
- Three different putative phosphate transport receptors are encoded by the Mycobacterium tuberculosis genome and are present at the surface of Mycobacterium bovis BCG.
- J Bacteriol. 1997 May;179(9):2900-6. doi: 10.1128/jb.179.9.2900-2906.1997.