Gene - combatTB X

pstB

Type: protein_coding
Name: pstB
Locus Name: Rv0933
Product: Phosphate-transport ATP-binding protein ABC transporter PstB
Functional Category: Cell wall and cell processes
Location: 1041264..1042094 (+ strand)
Gene Length: 830 bp
Nucleotides: TGGCGTGTGAACGGCTCGGCGGCCAGAGCGGTGCTGCTGATGTCGACGCCGCTGCGCCGGCGATGGCGGCGGTGAACCTCACCCTGGGTTTCGCTGGCAAAACCGTGCTCGACCAGGTGAGTATGGGCTTTCCCGCTCGTGCGGTGACGTCGTTGATGGGACCGACCGGTTCAGGTAAGACGACTTTTTTGCGCACCCTAAACCGGATGAATGACAAGGTCTCCGGTTACCGCTACAGCGGTGATGTGCTGTTGGGCGGACGCAGCATCTTCAACTACCGCGACGTGCTGGAGTTTCGCCGCCGGGTTGGCATGCTGTTCCAGCGCCCGAATCCGTTCCCGATGTCAATCATGGACAACGTGCTCGCCGGCGTGCGTGCCCACAAACTGGTGCCGCGCAAGGAATTCCGTGGCGTCGCGCAGGCTCGGCTTACCGAGGTCGGCCTCTGGGACGCGGTCAAGGATCGGCTCAGCGATTCACCGTTTCGACTCTCTGGTGGTCAGCAGCAGTTGTTGTGCCTAGCCCGTACGCTTGCGGTGAATCCGGAGGTGTTGCTGCTCGACGAGCCCACCTCCGCGCTGGACCCGACTACCACCGAGAAGATCGAAGAGTTCATCCGATCGCTCGCTGATCGCCTCACGGTGATCATCGTGACCCATAACCTTGCCCAGGCCGCCCGCATCAGCGACCGGGCGGCCCTGTTCTTCGACGGCAGGCTGGTGGAGGAAGGGCCCACCGAACAGCTGTTCTCCTCGCCGAAGCATGCGGAAACCGCCCGATACGTCGCCGGACTGTCGGGGGACGTCAAGGACGCCAAGCGCGGAAATTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. {ECO:0000255|HAMAP-Rule:MF_01702, ECO:0000305|PubMed:20933472}.

Family

ABC transporter superfamily, Phosphate importer (TC 3.A.1.7) family

GO

ATPase-coupled phosphate ion transmembrane transporter activity GO:0015415 molecular_function
inorganic phosphate transmembrane transporter activity GO:0005315 molecular_function
ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
ATPase activity GO:0016887 molecular_function

InterPro

UniProt: P9WQK9
GenBank: Rv0933
EnsemblBacteria: Rv0933
Mycobrowser: Rv0933

Summary

Name: Phosphate import ATP-binding protein PstB 2 (EC 7.3.2.1) (ABC phosphate transporter 2) (Phosphate-transporting ATPase 2)
Family: ABC transporter superfamily, Phosphate importer (TC 3.A.1.7) family
Protein Sequence: MACERLGGQSGAADVDAAAPAMAAVNLTLGFAGKTVLDQVSMGFPARAVTSLMGPTGSGKTTFLRTLNRMNDKVSGYRYSGDVLLGGRSIFNYRDVLEFRRRVGMLFQRPNPFPMSIMDNVLAGVRAHKLVPRKEFRGVAQARLTEVGLWDAVKDRLSDSPFRLSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRLTVIIVTHNLAQAARISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVAGLSGDVKDAKRGN
Mass: 29,996 Da
Length: 276 Aa

Rv0933 doesn't seem to be a targeted by any drug.

ABC transporters mtu02010
mtu02010
Environmental Information Processing; Membrane transport

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.: Tuberculosis (Edinb). 2010 Nov;90(6):338-45. doi: 10.1016/j.tube.2010.09.004. Epub 2010 Oct 8.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system.: Gene. 1996 Oct 17;176(1-2):171-6.