Gene - combatTB X

pstC1

Type: protein_coding
Name: pstC1
Locus Name: Rv0935
Product: Phosphate-transport integral membrane ABC transporter PstC1
Functional Category: Cell wall and cell processes
Location: 1043299..1044315 (+ strand)
Gene Length: 1016 bp
Nucleotides: TGCTGGCCCGTGCCGGTGAAGTCGGCCGCGCTGGCCCGGCCATCCGGTGGTTGGGTGGGATAGGTGCGGTGATCCCGCTGCTTGCGCTGGTCTTGGTGCTGGTGGTGCTGGTCATCGAGGCGATGGGTGCGATCAGGCTCAACGGGTTGCATTTCTTCACCGCCACCGAATGGAATCCAGGCAACACCTACGGCGAAACCGTTGTCACCGACGGCGTCGCCCATCCGGTCGGCGCCTACTACGGGGCGTTGCCGCTGATCGTCGGGACGCTGGCGACCTCGGCAATCGCCCTGATCATCGCGGTGCCGGTCTCTGTAGGAGCGGCGCTGGTGATCGTGGAACGGCTGCCGAAACGGTTGGCCGAGGCTGTGGGAATAGTCCTGGAATTGCTCGCCGGAATCCCCAGCGTGGTCGTCGGTTTGTGGGGGGCAATGACGTTCGGGCCGTTCATCGCTCATCACATCGCTCCGGTGATCGCTCACAACGCTCCCGATGTGCCGGTGCTGAACTACTTGCGCGGCGACCCGGGCAACGGGGAGGGCATGTTGGTGTCCGGTCTGGTGTTGGCGGTGATGGTCGTTCCCATTATCGCCACCACCACTCATGACCTGTTCCGGCAGGTGCCGGTGTTGCCCCGGGAGGGCGCGATCGCGCTGGGGATGTCGAATTGGGAGTGTGTCCGCAGGGTCACCCTGCCGTGGGTGTCCAGCGGCATCGTCGGTGCGGTGGTGCTAGGGCTTGGCCGTGCGCTGGGGGAGACGATGGCGGTAGCCATGGTGTCCGGCGCGGTGCTGGGGGCCATGCCCGCCAACATCTACGCGACCATGACCACCATCGCCGCCACCATCGTGTCGCAGCTGGATTCGGCGATGACCGATTCCACCAACTTCGCGGTGAAGACGCTCGCCGAGGTGGGTTTGGTGCTGATGGTGATCACGTTGCTGACTAATGTGGCCGCGCGCGGGATGGTTCGTCGGGTGTCACGCACCGCGCTTCCGGTGGGACGCGGCATCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate across the membrane. {ECO:0000305|PubMed:20933472}.

Family

Binding-protein-dependent transport system permease family, CysTW subfamily

GO

inorganic phosphate transmembrane transporter activity GO:0005315 molecular_function
plasma membrane GO:0005886 cellular_component
phosphate ion transport GO:0006817 biological_process
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WG07
GenBank: Rv0935
EnsemblBacteria: Rv0935
Mycobrowser: Rv0935

Summary

Name: Phosphate transport system permease protein PstC 1
Family: Binding-protein-dependent transport system permease family, CysTW subfamily
Protein Sequence: MLARAGEVGRAGPAIRWLGGIGAVIPLLALVLVLVVLVIEAMGAIRLNGLHFFTATEWNPGNTYGETVVTDGVAHPVGAYYGALPLIVGTLATSAIALIIAVPVSVGAALVIVERLPKRLAEAVGIVLELLAGIPSVVVGLWGAMTFGPFIAHHIAPVIAHNAPDVPVLNYLRGDPGNGEGMLVSGLVLAVMVVPIIATTTHDLFRQVPVLPREGAIALGMSNWECVRRVTLPWVSSGIVGAVVLGLGRALGETMAVAMVSGAVLGAMPANIYATMTTIAATIVSQLDSAMTDSTNFAVKTLAEVGLVLMVITLLTNVAARGMVRRVSRTALPVGRGI
Mass: 34,793 Da
Length: 338 Aa

Rv0935 doesn't seem to be a targeted by any drug.

ABC transporters mtu02010
mtu02010
Environmental Information Processing; Membrane transport

Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.: Tuberculosis (Edinb). 2010 Nov;90(6):338-45. doi: 10.1016/j.tube.2010.09.004. Epub 2010 Oct 8.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system.: Gene. 1996 Oct 17;176(1-2):171-6.