Gene - combatTB X

pstA2

Type: protein_coding
Name: pstA2
Locus Name: Rv0936
Product: Phosphate-transport integral membrane ABC transporter PstA2
Functional Category: Cell wall and cell processes
Location: 1044317..1045222 (+ strand)
Gene Length: 905 bp
Nucleotides: TGGGCGAATCGGCTGAGTCCGGGTCCCGGCAGCTACCGGCGATGTCCCCGCCGCGGCGATCGGTAGCCTATCGGCGCAAGATCGTCGATGCCCTGTGGTGGGCGGCGTGCGTGTGTTGTCTGGCGGTGGTGATCACCCCGACGTTGTGGATGTTGATCGGAGTCGTCAGCCGCGCTGTACCGGTTTTCCACTGGAGTGTGCTGGTGCAGGACTCCCAGGGCAATGGCGGCGGCTTGCGCAACGCCATCATCGGTACCGCAGTGTTGGCCATCGGGGTGATCCTGGTGGGTGGCACGGTGAGTGTGTTGACCGGGATTTATCTGTCCGAATTCGCCACCGGCAAAACACGGTCCATTCTGCGCGGCGCCTACGAGGTGTTGTCCGGTATTCCGTCGATCGTGCTCGGCTACGTCGGCTATTTGGCCCTGGTGGTGTACTTCGATTGGGGGTTTTCGCTGGCGGCCGGGGTGTTGGTGCTGTCGGTGATGAGCATTCCCTACATCGCCAAGGCCACCGAGTCCGCGCTGGCCCAGGTGCCGACGTCGTATCGGGAAGCGGCTGAGGCACTCGGGTTACCAGCCGGCTGGGCGCTGCGCAAGATCGTGCTGAAGACGGCGATGCCCGGAATCGTCACCGGGATGTTGGTCGCGCTGGCCCTGGCGATCGGCGAGACGGCGCCGCTGCTGTACACGGCGGGGTGGTCGAATTCGCCGCCGACCGGACAACTCACCGACTCGCCGGTCGGCTACCTGACCTACCCAATTTGGACGTTCTACAACCAGCCATCCAAGTCGGCTCAGGATCTGTCCTATGACGCGGCTCTCTTGCTGATCGTGTTCCTGCTGCTATTGATCTTCATTGGCCGGTTGATCAACTGGCTGTCACGGAGGCGTTGGGACGTTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. {ECO:0000305|PubMed:20933472}.

Family

Binding-protein-dependent transport system permease family, CysTW subfamily

GO

inorganic phosphate transmembrane transporter activity GO:0005315 molecular_function
integral component of plasma membrane GO:0005887 cellular_component
phosphate ion transmembrane transport GO:0035435 biological_process

InterPro

UniProt: P9WG09
GenBank: Rv0936
EnsemblBacteria: Rv0936
Mycobrowser: Rv0936

Summary

Name: Phosphate transport system permease protein PstA 2
Family: Binding-protein-dependent transport system permease family, CysTW subfamily
Protein Sequence: MGESAESGSRQLPAMSPPRRSVAYRRKIVDALWWAACVCCLAVVITPTLWMLIGVVSRAVPVFHWSVLVQDSQGNGGGLRNAIIGTAVLAIGVILVGGTVSVLTGIYLSEFATGKTRSILRGAYEVLSGIPSIVLGYVGYLALVVYFDWGFSLAAGVLVLSVMSIPYIAKATESALAQVPTSYREAAEALGLPAGWALRKIVLKTAMPGIVTGMLVALALAIGETAPLLYTAGWSNSPPTGQLTDSPVGYLTYPIWTFYNQPSKSAQDLSYDAALLLIVFLLLLIFIGRLINWLSRRRWDV
Mass: 32,236 Da
Length: 301 Aa

Rv0936 doesn't seem to be a targeted by any drug.

ABC transporters mtu02010
mtu02010
Environmental Information Processing; Membrane transport

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis.: Tuberculosis (Edinb). 2010 Nov;90(6):338-45. doi: 10.1016/j.tube.2010.09.004. Epub 2010 Oct 8.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system.: Gene. 1996 Oct 17;176(1-2):171-6.