Gene - combatTB X

purH

Type: protein_coding
Name: purH
Locus Name: Rv0957
Product: Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) (5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase) + inosinemonophosphate cyclohydrolase (imp cyclohydrolase) (inosinicase) (imp synthetase) (ATIC)
Functional Category: Intermediary metabolism and respiration
Location: 1068205..1069776 (+ strand)
Gene Length: 1571 bp
Nucleotides: TGAGCACCGACGACGGAAGACGGCCGATCCGCCGTGCGCTGATCAGCGTGTACGACAAGACCGGGCTGGTAGACCTGGCACAGGGCCTGAGCGCGGCCGGCGTCGAGATCATCTCGACTGGGTCAACGGCCAAGACCATTGCCGACACCGGGATTCCGGTGACCCCCGTGGAGCAGCTGACCGGCTTTCCCGAGGTGCTCGATGGCCGGGTCAAGACACTGCACCCACGAGTGCATGCCGGGCTGCTGGCTGACCTGCGCAAGTCCGAGCACGCCGCGGCCCTCGAGCAACTCGGGATCGAGGCTTTCGAACTCGTTGTAGTCAACTTGTATCCGTTCAGCCAGACCGTCGAATCCGGCGCCAGTGTCGACGACTGCGTCGAGCAGATTGATATCGGCGGGCCGGCGATGGTGCGGGCCGCCGCCAAAAACCATCCCAGCGCGGCGGTGGTCACCGATCCGCTTGGGTACCATGGCGTGCTTGCCGCACTGCGCGCCGGCGGATTCACCCTCGCCGAGCGCAAAAGGCTGGCGTCGTTAGCGTTTCAGCATATAGCCGAGTACGACATCGCCGTCGCGAGCTGGATGCAACAGACCCTAGCGCCCGAACATCCTGTTGCCGCCTTTCCGCAGTGGTTCGGCCGAAGCTGGCGCCGCGTGGCGATGCTGCGCTACGGCGAGAACCCGCACCAACAGGCCGCTCTCTACGGCGACCCCACCGCCTGGCCGGGGCTGGCCCAGGCCGAGCAACTGCACGGAAAAGACATGTCCTACAACAACTTCACCGATGCGGACGCAGCCTGGCGGGCCGCCTTCGACCACGAACAAACGTGCGTGGCGATCATCAAGCACGCCAACCCGTGCGGCATCGCAATCTCGTCCGTTTCGGTCGCCGACGCGCATCGCAAGGCTCACGAATGCGATCCGCTGAGCGCCTACGGCGGGGTCATCGCCGCCAATACCGAGGTCAGTGTCGAAATGGCCGAGTATGTGAGCACCATCTTCACCGAAGTCATCGTCGCGCCTGGCTACGCCCCCGGGGCCCTCGATGTGCTGGCCCGCAAGAAGAACATCCGGGTGCTGGTAGCCGCCGAGCCACTGGCCGGTGGCAGCGAGTTGCGTCCGATCAGCGGTGGACTGCTGATACAGCAGAGCGACCAGCTTGACGCGCACGGTGACAACCCGGCGAACTGGACCTTGGCGACCGGGTCACCTGCGGACCCCGCGACGCTGACCGACCTGGTCTTCGCGTGGCGAGCCTGCCGTGCGGTCAAGTCGAACGCGATAGTGATAGCTGCCGACGGCGCCACCGTCGGCGTCGGGATGGGTCAGGTCAACCGTGTCGACGCCGCCCGGTTGGCCGTCGAACGCGGCGGCGAGCGGGTTCGCGGCGCGGTGGCAGCCTCGGATGCGTTCTTCCCCTTTCCCGACGGCCTGGAAACGTTGGCCGCCGCGGGGGTCACCGCGGTCGTCCACCCCGGTGGCTCGGTGCGCGACGAGGAAGTGACCGAAGCGGCGGCCAAGGCCGGTGTCACCCTATATCTCACCGGGGCGCGGCACTTCGCGCACTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

PurH family

GO

IMP cyclohydrolase activity GO:0003937 molecular_function
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
'de novo' IMP biosynthetic process GO:0006189 biological_process
phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0004643 molecular_function

InterPro

UniProt: P9WHM7
GenBank: Rv0957
EnsemblBacteria: Rv0957
Mycobrowser: Rv0957

Summary

Name: Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]
Family: PurH family
Protein Sequence: MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLETLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH
Mass: 55,026 Da
Length: 523 Aa

Rv0957 doesn't seem to be a targeted by any drug.

Purine metabolism mtu00230
mtu00230
PATHWAY_MAP mtu00230 Purine metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.