Function

Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region. {ECO:0000269|PubMed:17143269}.

Family

CsoR family

GO

• response to copper ion GO:0046688 biological_process
• transcription regulatory region sequence-specific DNA binding GO:0000976 molecular_function
• response to silver ion GO:0010272 biological_process
• DNA-binding transcription repressor activity GO:0001217 molecular_function
• protein-DNA complex GO:0032993 cellular_component
• copper ion binding GO:0005507 molecular_function
• DNA binding GO:0003677 molecular_function
• negative regulation of transcription, DNA-templated GO:0045892 biological_process
• plasma membrane GO:0005886 cellular_component
• cytoplasm GO:0005737 cellular_component
• copper ion sensor activity GO:0097077 molecular_function

InterPro

• IPR038390
• IPR003735

UniProt

P9WP49

GenBank

Rv0967

EnsemblBacteria

Rv0967

Mycobrowser

Rv0967

Rv0967 doesn't seem to be a targeted by any drug.

Rv0967 doesn't seem to be involved in any pathway.