Gene - combatTB X

ctpV

Type: protein_coding
Name: ctpV
Locus Name: Rv0969
Product: Probable metal cation transporter P-type ATPase CtpV
Functional Category: Cell wall and cell processes
Location: 1078743..1081055 (+ strand)
Gene Length: 2312 bp
Nucleotides: TGCGCGTGTGCGTCACCGGGTTCAATGTCGATGCGGTTCGGGCCGTCGCGATTGAGGAGACGGTCTCCCAAGTGACCGGGGTGCACGCCGTGCACGCCTATCCGCGAACAGCGTCGGTGGTGATCTGGTACTCGCCAGAGCTCGGTGACACCGCCGCCGTGCTGTCGGCGATCACCAAAGCGCAGCACGTCCCGGCAGAATTGGTGCCCGCCCGTGCCCCGCACTCAGCGGGTGTGCGCGGCGTGGGCGTGGTGCGGAAAATCACCGGCGGGATCCGCCGCATGCTAAGTCGCCCGCCGGGCGTCGACAAGCCCCTGAAGGCGTCGCGTTGCGGCGGCCGCCCGCGCGGGCCGGTCCGCGGGAGCGCCTCGTGGCCGGGCGAGCAGAACCGGCGCGAGCGGCGGACGTGGTTGCCGCGGGTGTGGTTGGCCTTGCCGTTGGGGCTACTGGCGCTGGGTTCGTCAATGTTCTTCGGTGCTTACCCGTGGGCGGGGTGGCTGGCCTTCGCCGCGACGCTGCCGGTGCAATTCGTGGCCGGGTGGCCGATTCTGCGGGGGGCGGTGCAACAGGCGCGGGCGTTGACCTCGAACATGGACACGCTGATCGCGCTGGGTACGCTGACCGCGTTTGTCTACTCCACGTATCAGTTGTTTGCCGGTGGACCTCTGTTCTTCGACACCTCGGCGCTGATCATCGCGTTCGTGGTGTTGGGCCGCCATCTCGAGGCCAGAGCAACCGGAAAAGCGTCCGAGGCGATCAGCAAGCTGCTGGAGCTGGGCGCCAAGGAAGCCACGCTGCTTGTCGACGGCCAAGAGCTCCTGGTGCCGGTCGATCAGGTCCAAGTCGGAGACCTGGTGCGGGTGCGGCCCGGAGAGAAGATCCCGGTCGACGGTGAGGTCACCGATGGGCGCGCCGCCGTCGACGAGTCGATGCTCACCGGCGAATCCGTCCCGGTCGAGAAGACGGCGGGTGACCGCGTTGCCGGCGCAACGGTCAACCTCGACGGGCTGTTGACCGTGCGCGCCACCGCCGTCGGGGCAGACACCGCGCTGGCGCAGATTGTGCGACTGGTCGAGCAGGCACAGGGCGACAAGGCGCCGGTGCAGCGGCTGGCCGACCGGGTTTCGGCGGTGTTTGTCCCGGCCGTCATCGGCGTTGCCGTCGCGACCTTTGCGGGATGGACCCTGATCGCCGCCAACCCGGTGGCTGGTATGACCGCCGCGGTCGCGGTGCTGATCATCGCGTGCCCGTGTGCGTTGGGCCTGGCTACCCCCACGGCCATCATGGTCGGCACCGGCCGGGGCGCCGAACTGGGGATCCTGGTCAAGGGAGGCGAGGTGCTGGAAGCGTCGAAGAAGATCGACACCGTGGTGTTCGACAAGACCGGCACCCTCACCCGCGCCCGGATGCGGGTGACCGATGTGATTGCCGGCCAGCGGCGCCAGCCTGATCAGGTGCTGCGGCTCGCCGCCGCGGTCGAATCGGGCTCCGAACACCCCATCGGTGCGGCGATCGTTGCCGCTGCACACGAGCGCGGGTTGGCGATACCGGCCGCCAATGCGTTCACCGCCGTCGCCGGGCACGGGGTGCGGGCGCAGGTCAACGGCGGGCCGGTGGTGGTCGGACGGCGCAAGCTCGTCGACGAACAACATTTGGTTCTGCCCGACCACCTCGCTGCGGCGGCCGTGGAGCAGGAAGAGCGCGGCCGCACCGCGGTGTTCGTCGGCCAAGACGGCCAGGTTGTGGGTGTGCTCGCGGTAGCGGACACGGTCAAAGACGACGCCGCGGACGTGGTCGGTCGGCTGCACGCCATGGGGCTACAGGTAGCCATGATCACCGGCGACAACGCCCGCACGGCTGCCGCGATCGCCAAGCAGGTCGGCATCGAGAAGGTGCTGGCCGAGGTGTTGCCGCAGGACAAGGTAGCTGAGGTTCGGCGGCTGCAGGACCAGGGCCGGGTGGTCGCGATGGTGGGTGACGGCGTCAACGACGCGCCCGCCTTGGTACAAGCCGATCTGGGCATTGCGATCGGCACCGGTACCGACGTGGCCATCGAGGCCTCCGACATCACGCTAATGTCCGGCCGGCTCGATGGTGTCGTGCGCGCGATCGAACTCTCCAGGCAGACCCTGCGCACCATCTACCAGAATCTCGGCTGGGCCTTCGGCTACAACACCGCCGCGATCCCACTGGCCGCGCTGGGCGCGCTGAACCCGGTCGTGGCGGGCGCGGCGATGGGGTTCTCCTCGGTCAGCGTGGTGACCAACTCACTGCGGTTACGCCGCTTCGGCCGCGACGGCCGAACCGCATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence. {ECO:0000269|PubMed:20624225}.

Family

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily

GO

metal ion binding GO:0046872 molecular_function
copper transmembrane transporter activity, phosphorylative mechanism GO:0043682 molecular_function
plasma membrane GO:0005886 cellular_component
integral component of plasma membrane GO:0005887 cellular_component
ATP binding GO:0005524 molecular_function
cell wall GO:0005618 cellular_component
pathogenesis GO:0009405 biological_process
response to copper ion GO:0046688 biological_process

InterPro

UniProt: P9WPS3
GenBank: Rv0969
EnsemblBacteria: Rv0969
Mycobrowser: Rv0969

Summary

Name: Probable copper-exporting P-type ATPase V (EC 7.2.2.8) (Cu(+)-exporting ATPase)
Family: Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily
Protein Sequence: MRVCVTGFNVDAVRAVAIEETVSQVTGVHAVHAYPRTASVVIWYSPELGDTAAVLSAITKAQHVPAELVPARAPHSAGVRGVGVVRKITGGIRRMLSRPPGVDKPLKASRCGGRPRGPVRGSASWPGEQNRRERRTWLPRVWLALPLGLLALGSSMFFGAYPWAGWLAFAATLPVQFVAGWPILRGAVQQARALTSNMDTLIALGTLTAFVYSTYQLFAGGPLFFDTSALIIAFVVLGRHLEARATGKASEAISKLLELGAKEATLLVDGQELLVPVDQVQVGDLVRVRPGEKIPVDGEVTDGRAAVDESMLTGESVPVEKTAGDRVAGATVNLDGLLTVRATAVGADTALAQIVRLVEQAQGDKAPVQRLADRVSAVFVPAVIGVAVATFAGWTLIAANPVAGMTAAVAVLIIACPCALGLATPTAIMVGTGRGAELGILVKGGEVLEASKKIDTVVFDKTGTLTRARMRVTDVIAGQRRQPDQVLRLAAAVESGSEHPIGAAIVAAAHERGLAIPAANAFTAVAGHGVRAQVNGGPVVVGRRKLVDEQHLVLPDHLAAAAVEQEERGRTAVFVGQDGQVVGVLAVADTVKDDAADVVGRLHAMGLQVAMITGDNARTAAAIAKQVGIEKVLAEVLPQDKVAEVRRLQDQGRVVAMVGDGVNDAPALVQADLGIAIGTGTDVAIEASDITLMSGRLDGVVRAIELSRQTLRTIYQNLGWAFGYNTAAIPLAALGALNPVVAGAAMGFSSVSVVTNSLRLRRFGRDGRTA
Mass: 80,103 Da
Length: 770 Aa

Rv0969 doesn't seem to be a targeted by any drug.

Rv0969 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosis.: Mol Microbiol. 2010 Sep;77(5):1096-110. doi: 10.1111/j.1365-2958.2010.07273.x.
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.: Nat Chem Biol. 2007 Jan;3(1):60-8. doi: 10.1038/nchembio844. Epub 2006 Dec 3.
Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry.: J Proteome Res. 2005 May-Jun;4(3):855-61. doi: 10.1021/pr0500049.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.