Gene - combatTB X

accA2

Type: protein_coding
Name: accA2
Locus Name: Rv0973c
Product: Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Functional Category: Lipid metabolism
Location: 1083747..1085750 (- strand)
Gene Length: 2003 bp
Nucleotides: ATGGGAATCACTCGAGTATTGGTTGCTAACCGCGGCGAGATCGCCCGGCGGGTGTTCGCCACCTGCCGCCGGCTGGGGCTCGGCACCGTCGCCGTCTACACAGACCCGGATGCCGCGGCACCGCATGTCGCCGAGGCCGACGCCCGGGTCCGGCTGCCGCAGACCACCGACTATCTGAACGCCGAGGCGATCATCGCGGCCGCGCAGGCAGCCGGAGCCGACGCGGTGCATCCCGGCTACGGATTCCTCTCGGAGAACGCCGAATTCGCGGCCGCCGTGCAGGAGGCCGGCCTAACCTGGGTCGGGCCACCGGTGGACGCGGTGCGCGCGATGGGCTCCAAAATCGAGTCCAAGAAGCTGATGGCCGCCGCCGGGGTGCCGGTGCTCGAGGAACTCGACCCCGACGCCGTCACCACCGCGCAGCTGCCGGTGCTGGTGAAGGCGTCGGCGGGCGGTGGCGGTCGCGGCATGCGAGTGGTTCACGAATTATCGGCCCTGCCGGCCGAAGTCGAAGCCGCGCGACGTGAAGCCCAATCCGCGTTCGGCGACCCGACCGTATTCTGCGAGCGCTACCTGCCCACCGGGCACCACGTCGAAGTGCAAGTCATGGCCGACACCCATGGCACCGTGTGGGCGGTCGGGGAACGGGAATGCTCGATTCAGCGCCGCCACCAGAAGATCATCGAAGAGGCACCGTCGCCGCTGGTGGAACGCGTACCGGGGATGCGGGCCAAGCTGTTCGACGCGGCCCGGCTGGCGGCCAGCGCGATCGGCTACACCGGGGCAGGCACGGTGGAGTTCCTCGCCGATGACTCACCTGGCCGGGAAGGTGAGTTCTACTTCCTGGAGATGAACACCCGGCTACAGGTCGAGCACCCGGTCACCGAAGAGACCACCGGGCTGGATCTGGTCGAACTGCAGCTCATGATTGCCGACTGCGGGCGACTCGACACCGAACCTCCCCCCGCCCAGGGATATTCGATCGAGGCCCGCCTCTACGCCGAGGATCCCGCGCATGGCTGGCAGCCACAGGCAGGCGTGATGCACACGATTGAGGTTCCGGGGGTTCGGGCGCAGTTCGACTCGTTGGGACAGCGGACCGGCATCCGGCTGGATTCCGGGATCGTCGACGGTTCCACAGTGTCGATCCACTACGACCCAATGCTGGCCAAGGTCGTCTCCTACGGTGCCACCCGCCGGCAGGCCGCGCTTGTGTTGGCCGATGCGCTGGTACGCGCCCGGCTGCACGGTCTGCGCACCAACCGTGAGCTCTTGGTCAACGTGCTGCGTCATCCGGCGTTCCTCGACGGCGCCACCGACACCGGGTTTTTCGACACGCACGGCATGGCCGAGTTGTCGACACCGCTGGCCGACACCGCGACCCTCCGGTTGTCGGCGATCGCCGCCGCGCTGGCCGACGCCGAGCACAATCGGGCGAGCGCGGGCGTGTTCAGCTCGATTCCCAGCGGCTGGCGCAACCTGGCCTCGGGCTATCAGGTCAAGACCTATCGTGACGACGCGGACACCGAACACCGCGTCGAATACCGGTTCACCAGAACGGGTCTGGCGCTTCCCGGCGATCCGGTGGTACAGCTGGTCTCGGCTGACGTGGACCAGGTGGTGCTCGCCCAGGACGGGGTCGCACACGGCTTCACGGTTGCCCGCCACGGCCCCGACGTCTACGTCGACTCGGCGCGCGGACCCGTTCACCTGGTGGCACTGTCACGCTTCCCCGAGCCGAGCTCGGCCGTCGAGCAAGGCTCGCTGGTGGCCCCCATGCCCGGCAACGTCATCCGGATCGGCGCCGAGGTTGGCGACACGGTCACGGCCGGTCAGCCGTTGATCTGGCTGGAGGCCATGAAGATGGAACACACCATCGCCGCGCCTGCCGACGGCGTGCTCACCCACGTCAGCGTCAACACGGGTCAACAGGTCGAAGTAGGCGCCATTCTCGCACGAGTAGAAGCACCTCAAAATGGCCCAGCAGAAGGAGATTCACCGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

plasma membrane GO:0005886 cellular_component
ATP binding GO:0005524 molecular_function
metal ion binding GO:0046872 molecular_function

InterPro

UniProt: P71538
GenBank: Rv0973c
EnsemblBacteria: Rv0973c
Mycobrowser: Rv0973c

Summary

Name: Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (Alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Family: Unknown
Protein Sequence: MGITRVLVANRGEIARRVFATCRRLGLGTVAVYTDPDAAAPHVAEADARVRLPQTTDYLNAEAIIAAAQAAGADAVHPGYGFLSENAEFAAAVQEAGLTWVGPPVDAVRAMGSKIESKKLMAAAGVPVLEELDPDAVTTAQLPVLVKASAGGGGRGMRVVHELSALPAEVEAARREAQSAFGDPTVFCERYLPTGHHVEVQVMADTHGTVWAVGERECSIQRRHQKIIEEAPSPLVERVPGMRAKLFDAARLAASAIGYTGAGTVEFLADDSPGREGEFYFLEMNTRLQVEHPVTEETTGLDLVELQLMIADCGRLDTEPPPAQGYSIEARLYAEDPAHGWQPQAGVMHTIEVPGVRAQFDSLGQRTGIRLDSGIVDGSTVSIHYDPMLAKVVSYGATRRQAALVLADALVRARLHGLRTNRELLVNVLRHPAFLDGATDTGFFDTHGMAELSTPLADTATLRLSAIAAALADAEHNRASAGVFSSIPSGWRNLASGYQVKTYRDDADTEHRVEYRFTRTGLALPGDPVVQLVSADVDQVVLAQDGVAHGFTVARHGPDVYVDSARGPVHLVALSRFPEPSSAVEQGSLVAPMPGNVIRIGAEVGDTVTAGQPLIWLEAMKMEHTIAAPADGVLTHVSVNTGQQVEVGAILARVEAPQNGPAEGDSP
Mass: 70,745 Da
Length: 667 Aa

Rv0973c doesn't seem to be a targeted by any drug.

Propanoate metabolism mtu00640
mtu00640
PATHWAY_MAP mtu00640 Propanoate metabolism

Glyoxylate and dicarboxylate metabolism mtu00630
mtu00630
PATHWAY_MAP mtu00630 Glyoxylate and dicarboxylate metabolism

Valine, leucine and isoleucine degradation mtu00280
mtu00280
PATHWAY_MAP mtu00280 Valine, leucine and isoleucine degradation

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.