Gene - combatTB X

PE_PGRS16

Type: protein_coding
Name: PE_PGRS16
Locus Name: Rv0977
Product: PE-PGRS family protein PE_PGRS16
Functional Category: Pe/ppe
Location: 1090373..1093144 (+ strand)
Gene Length: 2771 bp
Nucleotides: TGTCCTTCGTGGTCACAGCACCGCCGGTGCTCGCGTCGGCGGCGTCGGATCTGGGCGGTATCGCGTCCATGATCAGCGAGGCCAACGCGATGGCAGCGGTCCGAACGACGGCGTTGGCGCCCGCCGCCGCCGACGAGGTTTCGGCGGCGATCGCGGCGCTGTTTTCCAGCTACGCGCGGGACTATCAAACGCTGAGCGTCCAGGTGACGGCCTTCCACGTGCAGTTCGCGCAGACATTGACCAATGCGGGGCAGCTGTATGCGGTCGTCGACGTCGGCAATGGCGTGCTGTTGAAGACCGAGCAGCAGGTGCTGGGTGTGATCAATGCGCCCACCCAGACGTTGGTGGGTCGTCCGCTGATCGGCGATGGCACCCACGGGGCGCCGGGGACCGGGCAGAACGGTGGGGCGGGCGGAATCTTGTGGGGCAACGGCGGTAACGGCGGGTCCGGGGCTCCCGGACAGCCGGGCGGCCGGGGCGGTGATGCCGGCCTGTTCGGCCACGGCGGTCATGGCGGTGTCGGGGGGCCGGGCATCGCCGGTGCCGCTGGCACCGCGGGCCTGCCCGGGGGCAACGGCGCCAACGGCGGAAGCGGCGGCATCGGCGGCGCCGGCGGCGCCGGCGGCAACGGCGGGCTGCTATTCGGCAACGGTGGTGCCGGCGGCCAGGGTGGCTCCGGCGGACTTGGGGGCTCCGGCGGGACGGGCGGCGCGGGCATGGCTGCCGGTCCCGCCGGCGGCACCGGCGGCATCGGGGGCATCGGCGGCATCGGCGGCGCGGGCGGGGTCGGCGGCCACGGCTCGGCGTTGTTCGGCCACGGGGGAATCAACGGCGATGGCGGTACCGGCGGCATGGGTGGCCAGGGCGGTGCTGGCGGCAACGGCTGGGCCGCTGAGGGCATCACGGTCGGCATTGGTGAGCAAGGCGGCCAGGGCGGCGACGGGGGAGCCGGCGGCGCCGGCGGGATCGGTGGTTCGGCGGGTGGGATCGGCGGCAGCCAGGGTGCGGGTGGGCACGGCGGCGACGGCGGCCAGGGCGGCGCCGGCGGTAGTGGCGGCGTTGGCGGCGGCGGCGCAGGCGCCGGCGGCGACGGCGGCGCGGGCGGCATCGGCGGCACTGGCGGTAACGGCAGCATCGGCGGGGCCGCCGGCAATGGCGGTAACGGCGGCCGCGGCGGCGCCGGTGGCATGGCCACCGCGGGAAGTGATGGCGGCAATGGCGGCGGCGGCGGCAACGGCGGCGTCGGTGTTGGCAGCGCCGGAGGGGCCGGCGGCACCGGCGGTGACGGCGGGGCGGCCGGGGCGGGCGGCGCGCCGGGCCACGGCTACTTCCAACAGCCCGCGCCCCAAGGGCTGCCCATCGGAACCGGCGGGACCGGCGGCGAAGGCGGTGCCGGCGGCGCCGGTGGAGACGGCGGGCAGGGCGACATCGGCTTCGATGGCGGCCGGGGTGGCGACGGCGGCCCGGGCGGTGGCGGCGGCGCCGGCGGTGACGGCAGCGGCACCTTCAATGCCCAAGCCAACAACGGCGGCGACGGTGGTGCCGGCGGTGTTGGGGGAGCCGGCGGCACCGGCGGCACGGGTGGGGTCGGGGCCGACGGGGGTCGCGGGGGGGACTCGGGCCGCGGCGGCGACGGCGGCAACGCCGGCCACGGCGGCGCCGCCCAATTCTCCGGTCGCGGCGCCTACGGCGGTGAAGGTGGCAGCGGCGGCGCCGGCGGCAACGCCGGTGGCGCCGGCACCGGTGGCACCGCGGGCTCCGGCGGTGCCGGAGGTTTCGGCGGCAACGGTGCCGATGGCGGCAATGGCGGCAACGGTGGCAACGGCGGCTTCGGCGGAATTAACGGCACGTTCGGCACCAACGGTGCCGGCGGCACCGGCGGGCTCGGCACCCTGCTCGGCGGCCACAACGGCAACATCGGCCTCAACGGGGCCACCGGCGGCATCGGCAGCACCACGTTGACCAACGCGACCGTACCGCTGCAGCTGGTGAATACCACCGAGCCGGTGGTATTCATCTCCTTAAACGGCGGCCAAATGGTGCCCGTGCTGCTCGACACCGGATCCACCGGTCTGGTCATGGACAGCCAATTCCTGACGCAGAACTTCGGCCCCGTCATCGGGACGGGCACCGCCGGTTACGCCGGCGGGCTGACCTACAACTACAACACCTACTCAACGACGGTGGATTTCGGCAATGGCCTTCTCACCCTGCCGACCAGCGTTAACGTCGTCACCTCGTCATCACCGGGAACCCTGGGCAACTTCTTGTCGAGATCCGGTGCGGTGGGCGTCTTGGGAATCGGGCCCAACAACGGGTTCCCGGGCACCAGCTCCATCGTTACCGCGATGCCCGGCCTGCTCAACAACGGTGTGCTCATCGACGAATCGGCGGGCATCCTGCAGTTCGGTCCCAACACATTAACCGGCGGTATCACGATTTCTGGAGCACCGATTTCCACCGTGGCTGTTCAGATCGACAACGGGCCGCTGCAACAAGCTCCGGTGATGTTCGACTCCGGCGGCATCAACGGAACCATCCCGTCAGCCCTCGCCAGCCTGCCGTCCGGGGGATTCGTGCCGGCGGGAACGACCATTTCGGTCTACACCAGCGACGGCCAGACGCTGTTGTACTCCTACACCACCACCGCGACAAACACCCCATTTGTCACCTCCGGCGGCGTGATGAACACCGGGCACGTCCCCTTCGCGCAGCAACCGATATACGTCTCCTACAGCCCCACCGCCATCGGGACGACCACCTTTAACTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Mycobacterial PE family, PGRS subfamily

GO

metal ion binding GO:0046872 molecular_function
cell surface GO:0009986 cellular_component

InterPro

UniProt: Q79FU3
GenBank: Rv0977
EnsemblBacteria: Rv0977
Mycobrowser: Rv0977

Summary

Name: PE-PGRS family protein PE_PGRS16
Family: Mycobacterial PE family, PGRS subfamily
Protein Sequence: MSFVVTAPPVLASAASDLGGIASMISEANAMAAVRTTALAPAAADEVSAAIAALFSSYARDYQTLSVQVTAFHVQFAQTLTNAGQLYAVVDVGNGVLLKTEQQVLGVINAPTQTLVGRPLIGDGTHGAPGTGQNGGAGGILWGNGGNGGSGAPGQPGGRGGDAGLFGHGGHGGVGGPGIAGAAGTAGLPGGNGANGGSGGIGGAGGAGGNGGLLFGNGGAGGQGGSGGLGGSGGTGGAGMAAGPAGGTGGIGGIGGIGGAGGVGGHGSALFGHGGINGDGGTGGMGGQGGAGGNGWAAEGITVGIGEQGGQGGDGGAGGAGGIGGSAGGIGGSQGAGGHGGDGGQGGAGGSGGVGGGGAGAGGDGGAGGIGGTGGNGSIGGAAGNGGNGGRGGAGGMATAGSDGGNGGGGGNGGVGVGSAGGAGGTGGDGGAAGAGGAPGHGYFQQPAPQGLPIGTGGTGGEGGAGGAGGDGGQGDIGFDGGRGGDGGPGGGGGAGGDGSGTFNAQANNGGDGGAGGVGGAGGTGGTGGVGADGGRGGDSGRGGDGGNAGHGGAAQFSGRGAYGGEGGSGGAGGNAGGAGTGGTAGSGGAGGFGGNGADGGNGGNGGNGGFGGINGTFGTNGAGGTGGLGTLLGGHNGNIGLNGATGGIGSTTLTNATVPLQLVNTTEPVVFISLNGGQMVPVLLDTGSTGLVMDSQFLTQNFGPVIGTGTAGYAGGLTYNYNTYSTTVDFGNGLLTLPTSVNVVTSSSPGTLGNFLSRSGAVGVLGIGPNNGFPGTSSIVTAMPGLLNNGVLIDESAGILQFGPNTLTGGITISGAPISTVAVQIDNGPLQQAPVMFDSGGINGTIPSALASLPSGGFVPAGTTISVYTSDGQTLLYSYTTTATNTPFVTSGGVMNTGHVPFAQQPIYVSYSPTAIGTTTFN
Mass: 81,604 Da
Length: 923 Aa

Rv0977 doesn't seem to be a targeted by any drug.

Rv0977 doesn't seem to be involved in any pathway.

Crystal structure of a putative aspartic proteinase domain of the Mycobacterium tuberculosis cell surface antigen PE_PGRS16.: FEBS Open Bio. 2013 Jun 8;3:256-62. doi: 10.1016/j.fob.2013.05.004. Print 2013.
A comparative study of host response to three Mycobacterium tuberculosis PE_PGRS proteins.: Microbiology. 2008 Nov;154(Pt 11):3469-79. doi: 10.1099/mic.0.2008/019968-0.
Mycobacterium tuberculosis invasion and traversal across an in vitro human blood-brain barrier as a pathogenic mechanism for central nervous system tuberculosis.: J Infect Dis. 2006 May 1;193(9):1287-95. doi: 10.1086/502631. Epub 2006 Mar 28.
Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo.: J Bacteriol. 2006 May;188(10):3721-5. doi: 10.1128/JB.188.10.3721-3725.2006.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.