PE_PGRS17

Type
protein_coding
Name
PE_PGRS17
Locus Name

Rv0978c

Product

PE-PGRS family protein PE_PGRS17

Functional Category

Pe/ppe

Location
1093361..1094356 (- strand)
Gene Length
995 bp
Nucleotides
ATGTCGTTTGTCAACGTGGCCCCACAGTTAGTGTCCACAGCCGCGGCCGATGCAGCGCGGATCGGCTCGGCGATCAACACCGCCAACACCGCGGCGGCGGCGACCACCCAGGTGTTGGCCGCCGCCCAAGACGAGGTGTCAACGGCGATCGCCGCGCTGTTCGGCAGCCACGGCCAGCACTATCAAGCGATCAGCGCGCAGGTCGCGGCCTATCAGCAACGGTTCGTGCTGGCCTTAAGCCAAGCTGGCAGCACCTACGCGGTCGCCGAAGCGGCCAGCGCAACACCGCTGCAGAACGTGCTCGATGCGATCAACGCACCCGTTCAGTCGCTGACCGGGCGCCCATTGATCGGCGACGGCGCGAACGGGATCGACGGGACCGGGCAAGCCGGCGGTAACGGCGGGTGGCTGTGGGGCAACGGCGGCAACGGCGGGTCGGGGGCACCCGGACAGGCCGGCGGCGCCGGCGGGGCGGCCGGGTTGATCGGCAACGGTGGGGCCGGCGGCACCGGCGGCGCGGTCAGCCTCGCCCGCGCCGGCACGGCCGGCGGTGCCGGCCGCGGCCCGGTCGGCGGTATCGGCGGTGCGGGTGGGGTCGGCGGTGCCGGTGGGGCCGCCGGCGCCGTCACCACCATCACCCACGCCAGCTTCAACGATCCGCACGGGGTGGCGGTCAACCCGGGCGGCAACGTCTACGTCACCAATTTCGGCAGCGGCACGGTGTCGGTGATCAACCCCGCCACCAACACCGTCACCGGCTCCCCCATCACCATCGGCAACGGTCCAAGCGGGGTGGCGGTCAGCCCCGTCACCGGCCTGGTCTTCGTGACCAACTTCGACAGCAACACGGTGTCGGTGATCGACCCGACCACCAACACCGTCACCGGCTCCCCCATCACCGTCGGCACCGCTCCGACCGGGGTGGCGGTCAACCCCGTCACCGGCGAGGTTTATGTCACCAACTTCGCCGGCGACACGGTGTCGGTAATCAGCTG
Drug Resistance

Check for drug resistance association at TBDREAMDB

Mutations

Check for mutants available at TARGET

Function
Induces maturation and activation of human dendritic cells (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa-B signaling pathways, and enhances the ability of DCs to stimulate CD4(+) T cells. By activating DCs, could potentially contribute to the initiation of innate immune responses during tuberculosis infection and hence regulate the clinical course of tuberculosis. {ECO:0000269|PubMed:20176745}.
Family

Mycobacterial PE family, PGRS subfamily

GO
InterPro
UniProt
Q79FU2
GenBank
Rv0978c
EnsemblBacteria
Rv0978c
Mycobrowser
Rv0978c
Summary
Name
PE-PGRS family protein PE_PGRS17
Family
Mycobacterial PE family, PGRS subfamily
Protein Sequence
MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDEVSTAIAALFGSHGQHYQAISAQVAAYQQRFVLALSQAGSTYAVAEAASATPLQNVLDAINAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWGNGGNGGSGAPGQAGGAGGAAGLIGNGGAGGTGGAVSLARAGTAGGAGRGPVGGIGGAGGVGGAGGAAGAVTTITHASFNDPHGVAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS
Mass
31,019 Da
Length
331 Aa

Rv0978c doesn't seem to be a targeted by any drug.

Rv0978c doesn't seem to be involved in any pathway.