Gene - combatTB X

Rv1002c

Type: protein_coding
Name: Rv1002c
Locus Name: Rv1002c
Product: Conserved membrane protein
Functional Category: Cell wall and cell processes
Location: 1118428..1119939 (- strand)
Gene Length: 1511 bp
Nucleotides: GTGGTACCCGTCGTCAGCCCCGGCCCGCTGGTGCCGGTCGCGGATTTCGGGCCCCTGGACCGGTTACGCGGCTGGATCGTGACCGGCCTGATCACGCTGCTGGCCACGGTGACCCGGTTCCTGAACCTGGGCTCGCTGACCGATGCCGGCACCCCCATCTTCGACGAGAAGCATTACGCACCCCAGGCCTGGCAGGTGCTGAACAACCATGGGGTGGAAGACAACCCCGGGTACGGCCTGGTGGTTCACCCGCCGGTCGGTAAGCAGCTGATCGCGATCGGGGAGGCCATCTTCGGTTACAACGGATTCGGCTGGCGGTTCACCGGCGCCCTGCTGGGTGTGGTCCTGGTGGCGCTGGTGGTGCGGATCGTGCGGCGGATCAGCCGGTCGACATTGGTCGGCGCCATCGCCGGGGTGCTGCTGATCTGCGACGGGGTCAGCTTCGTCACCGCGCGGACCGCGCTGCTGGACGGCTTCCTGACGTTCTTCGTCGTCGCGGCGTTCGGCGCGCTCATCGTCGACCGCGATCAGGTTCGCGAACGGATGCACATCGCTCTGCTGGCCGGCCGCAGCGCCGCCACCGTGTGGGGACCGCGGGTGGGTGTGCGCTGGTGGCGGTTCGGCGCCGGGGTGCTGCTGGGATTGGCTTGCGCCACCAAGTGGTCCGGCGTGTACTTCGTGCTGTTCTTCGGCGCGATGGCGCTGGCGTTCGACGTGGCGGCGCGACGTCAGTACCAAGTGCAAAGACCGTGGCTGGGGACAGTGCGGCGTGACGTGCTTCCCAGCGGGTATGCGCTGGGGTTGATCCCGTTCGCGGTCTATCTGGCCACCTACGCTCCGTGGTTCGCGTCCGAGACCGCGATCGATCGGCATGCGGTCGGTCAAGCGGTCGGTCGCAACTCGGTTGTTCCGCTGCCCGACGCCGTGCGCTCGCTCTGGCACTACACCGCCAAAGCGTTCCACTTCCACGCGGGCCTGACGAATTCCGCAGGCAACTACCACCCTTGGGAATCCAAACCGTGGACCTGGCCCATGTCGTTGCGGCCGGTGCTGTACGCCATCGACCAGCAAGACGTTGCAGGCTGCGGCGCACAGTCGTGCGTCAAGGCCGAGATGCTGGTCGGCACGCCCGCGATGTGGTGGCTGGCGGTGCCAGTCCTGGCATACGCGGGGTGGCGTATGTTTGTGCGCCGGGACTGGCGTTATGCGGTGGTCCTGGTCGGCTACTGCGCCGGTTGGCTGCCGTGGTTCGCCGACATCGACCGGCAGATGTACTTCTTCTACGCAGCGACCATGGCGCCATTTCTGGTGATGGGCATTTCGCTGGTTCTCGGCGATATCCTCTATCACCCCGGTCAGGGCTCCGAACGACGCACACTGGGGCTGATCGTCGTCTGCTGCTACGTGGCCCTCGTGGTGACGAACTTTGCGTGGCTGTATCCGGTGCTCACCGGTCTGCCAATCTCACAACAGACCTGGAACCTGGAGATCTGGCTGCCCAGCTGGCGGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins (Probable). Mannosylates an artificial substrate, probably on a Thr residue, upon expression in M.smegmatis. Glycosylation probably requires the Sec-translocation system. {ECO:0000269|PubMed:16081738, ECO:0000305}.

Family

Glycosyltransferase 39 family

GO

plasma membrane GO:0005886 cellular_component
protein O-linked mannosylation GO:0035269 biological_process
dolichyl-phosphate-mannose-protein mannosyltransferase activity GO:0004169 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: P9WN05
GenBank: Rv1002c
EnsemblBacteria: Rv1002c
Mycobrowser: Rv1002c

Summary

Name: Probable dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109)
Family: Glycosyltransferase 39 family
Protein Sequence: MTARPPESCVLAKDRPEEPVVPVVSPGPLVPVADFGPLDRLRGWIVTGLITLLATVTRFLNLGSLTDAGTPIFDEKHYAPQAWQVLNNHGVEDNPGYGLVVHPPVGKQLIAIGEAIFGYNGFGWRFTGALLGVVLVALVVRIVRRISRSTLVGAIAGVLLICDGVSFVTARTALLDGFLTFFVVAAFGALIVDRDQVRERMHIALLAGRSAATVWGPRVGVRWWRFGAGVLLGLACATKWSGVYFVLFFGAMALAFDVAARRQYQVQRPWLGTVRRDVLPSGYALGLIPFAVYLATYAPWFASETAIDRHAVGQAVGRNSVVPLPDAVRSLWHYTAKAFHFHAGLTNSAGNYHPWESKPWTWPMSLRPVLYAIDQQDVAGCGAQSCVKAEMLVGTPAMWWLAVPVLAYAGWRMFVRRDWRYAVVLVGYCAGWLPWFADIDRQMYFFYAATMAPFLVMGISLVLGDILYHPGQGSERRTLGLIVVCCYVALVVTNFAWLYPVLTGLPISQQTWNLEIWLPSWR
Mass: 57,607 Da
Length: 522 Aa

Rv1002c doesn't seem to be a targeted by any drug.

Mannose type O-glycan biosynthesis mtu00515
mtu00515
Metabolism; Glycan biosynthesis and metabolism

Other types of O-glycan biosynthesis mtu00514
mtu00514
Metabolism; Glycan biosynthesis and metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Export-mediated assembly of mycobacterial glycoproteins parallels eukaryotic pathways.: Science. 2005 Aug 5;309(5736):941-3. doi: 10.1126/science.1114347.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.