Gene - combatTB X

metS

Type: protein_coding
Name: metS
Locus Name: Rv1007c
Product: Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)
Functional Category: Information pathways
Location: 1125444..1127003 (- strand)
Gene Length: 1559 bp
Nucleotides: ATGAAGCCCTATTACGTCACCACCGCGATCGCATATCCCAACGCTGCACCCCACGTAGGTCACGCCTACGAATACATCGCCACCGACGCGATCGCCCGGTTCAAACGGCTGGATCGCTATGACGTGCGCTTCCTGACCGGGACCGACGAGCATGGCCTGAAGGTCGCACAAGCCGCCGCGGCAGCGGGCGTGCCCACCGCGGCGCTTGCCCGGCGCAATTCCGACGTGTTTCAGCGCATGCAGGAGGCGCTGAACATCTCCTTCGACCGATTCATCCGCACTACCGATGCCGACCACCACGAGGCGTCCAAGGAACTCTGGCGACGGATGTCGGCGGCCGGCGACATCTATCTGGACAACTATTCCGGGTGGTACTCGGTGCGCGACGAGCGGTTCTTCGTCGAATCGGAGACCCAACTTGTCGACGGCACGCGCCTGACGGTAGAGACCGGCACGCCGGTGACCTGGACCGAGGAGCAGACCTACTTCTTCCGGCTGTCGGCCTATACCGACAAGCTGCTGGCCCACTATCACGCCAACCCCGACTTCATCGCGCCGGAGACGCGGCGCAACGAAGTGATCAGCTTCGTCTCCGGCGGCCTGGACGACCTGTCGATCTCGCGCACCTCGTTTGACTGGGGTGTGCAGGTGCCCGAGCACCCCGACCACGTCATGTACGTCTGGGTCGACGCGCTGACCAATTACCTGACCGGGGCGGGCTTCCCGGATACCGACTCGGAGTTGTTCCGCCGCTACTGGCCCGCCGATTTGCACATGATCGGCAAGGACATCATCAGGTTTCATGCCGTCTATTGGCCGGCGTTTTTGATGTCAGCCGGAATCGAGTTGCCGCGAAGGATCTTCGCGCACGGGTTCTTGCACAACCGCGGCGAGAAGATGAGTAAATCGGTGGGCAACATCGTCGACCCGGTTGCCCTGGCGGAAGCGCTCGGGGTGGACCAGGTCCGCTACTTCCTGTTGCGGGAGGTCCCGTTCGGCCAGGACGGCAGTTACAGCGACGAGGCCATCGTCACTCGGATCAACACCGATCTGGCCAACGAGCTCGGCAACTTGGCCCAACGCTCGTTGTCGATGGTGGCCAAAAACCTTGACGGCAGGGTGCCCAACCCGGGTGAGTTCGCCGACGCCGACGCCGCGCTGCTTGCGACCGCCGATGGCTTGTTGGAGCGAGTGCGCGGTCACTTCGACGCACAGGCGATGCACCTGGCGCTGGAGGCGATCTGGCTGATGCTCGGCGACGCGAACAAGTACTTTTCGGTGCAGCAGCCGTGGGTACTGCGCAAGAGCGAGTCCGAAGCCGATCAGGCCCGGTTCCGCACCACGCTCTACGTCACCTGCGAGGTAGTCCGCATCGCGGCACTGCTGATCCAGCCGGTGATGCCGGAGTCGGCCGGCAAAATTTTGGACCTGCTCGGCCAGGCCCCAAACCAGCGGTCGTTCGCCGCCGTAGGTGTTCGGCTGACCCCCGGCACAGCGCTGCCGCCGCCCACCGGGGTATTTCCCCGCTACCAGCCGCCGCAACCACCCGAAGGCAAGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

Family

Class-I aminoacyl-tRNA synthetase family, MetG type 2B subfamily

GO

ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
cytoplasm GO:0005737 cellular_component
methionine-tRNA ligase activity GO:0004825 molecular_function
methionyl-tRNA aminoacylation GO:0006431 biological_process

InterPro

UniProt: P9WFU5
GenBank: Rv1007c
EnsemblBacteria: Rv1007c
Mycobrowser: Rv1007c

Summary

Name: Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)
Family: Class-I aminoacyl-tRNA synthetase family, MetG type 2B subfamily
Protein Sequence: MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDRYDVRFLTGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASKELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYFFRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPDHVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVRGHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRIAALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPEGK
Mass: 58,093 Da
Length: 519 Aa

Rv1007c doesn't seem to be a targeted by any drug.

Selenocompound metabolism mtu00450
mtu00450
PATHWAY_MAP mtu00450 Selenocompound metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Biochemical and phylogenetic analyses of methionyl-tRNA synthetase isolated from a pathogenic microorganism, Mycobacterium tuberculosis.: FEBS Lett. 1998 May 8;427(2):259-62.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.