ispE
- Type
- protein_coding
- Name
- ispE
- Locus Name
-
Rv1011
- Product
-
Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1130191..1131111 (+ strand)
- Gene Length
- 920 bp
- Nucleotides
-
TGCCCACCGGGTCGGTCACCGTTCGGGTGCCCGGAAAGGTCAACCTCTATCTGGCGGTCGGCGATCGCCGCGAGGACGGCTATCACGAGCTGACCACGGTATTTCATGCCGTCTCGCTGGTCGACGAGGTAACCGTTCGTAACGCTGATGTGCTCTCGCTCGAGTTGGTCGGCGAGGGGGCCGACCAGCTGCCGACCGACGAACGCAATCTCGCCTGGCAGGCGGCCGAGCTGATGGCCGAACACGTGGGCCGGGCGCCGGACGTCTCGATCATGATCGACAAATCCATTCCGGTCGCCGGCGGCATGGCCGGTGGCAGCGCGGACGCTGCGGCGGTCCTGGTTGCGATGAACTCGTTGTGGGAACTCAATGTGCCCCGCCGCGACCTGCGCATGCTCGCCGCGCGGCTAGGCAGCGATGTGCCGTTTGCCCTGCATGGTGGTACCGCGCTGGGGACGGGTCGCGGCGAGGAGTTGGCCACCGTGTTATCCCGCAACACCTTCCACTGGGTCCTGGCGTTCGCCGACAGCGGGTTGCTCACCTCCGCGGTGTACAACGAGCTCGACCGGCTCAGGGAGGTGGGGGATCCGCCCCGGCTTGGTGAGCCCGGGCCGGTTCTGGCTGCCTTAGCTGCGGGTGATCCGGATCAGCTGGCGCCGTTGCTGGGTAATGAAATGCAAGCGGCCGCGGTGAGCCTGGACCCGGCGCTGGCTCGTGCGTTACGCGCCGGTGTGGAGGCCGGCGCGCTCGCAGGCATCGTGTCCGGTTCGGGTCCCACGTGTGCCTTCCTGTGCACCTCGGCGAGCTCGGCGATCGATGTCGGCGCGCAGCTGTCGGGGGCGGGAGTTTGTCGCACCGTTCGAGTCGCCACCGGGCCGGTACCCGGCGCCCGCGTGGTGTCTGCGCCGACCGAAGTGTGA
- Drug Resistance
- Mutations
- Function
- Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. {ECO:0000255|HAMAP-Rule:MF_00061}.
- Family
-
GHMP kinase family, IspE subfamily
- GO
-
- isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway GO:0019288 biological_process
- ATP binding GO:0005524 molecular_function
- 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity GO:0050515 molecular_function
- terpenoid biosynthetic process GO:0016114 biological_process
- InterPro
3PYD
- Name
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)
- Family
- GHMP kinase family, IspE subfamily
- Protein Sequence
-
MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTEV
- Mass
- 31,382 Da
- Length
- 306 Aa
Summary
Rv1011 doesn't seem to be a targeted by any drug.
-
-
Terpenoid backbone biosynthesis mtu00900
mtu00900Metabolism; Metabolism of terpenoids and polyketides
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.