Gene - combatTB X

rplY

Type: protein_coding
Name: rplY
Locus Name: Rv1015c
Product: 50S ribosomal protein L25 RplY
Functional Category: Information pathways
Location: 1133921..1134568 (- strand)
Gene Length: 647 bp
Nucleotides: ATGGCCAAATCCGCAAGCAACCAGCTGCGCGTCACGGTGCGTACCGAGACCGGCAAGGGCGCGTCCCGGCGGGCCCGGCGCGCCGGCAAGATACCCGCTGTGCTGTATGGCCACGGCGCCGAGCCACAGCACCTGGAGCTGCCCGGACACGACTATGCGGCCGTACTGCGGCATTCCGGCACCAACGCGGTGTTGACCCTCGACATCGCCGGTAAGGAACAGCTGGCACTGACCAAGGCACTTCATATCCATCCGATCCGCCGCACCATCCAGCATGCCGACCTACTGGTCGTGCGCCGTGGCGAGAAGGTCGTCGTCGAAGTCAGCGTGGTCGTCGAGGGCCAGGCCGGACCCGACACCCTGGTCACCCAAGAGACCAACAGCATCGAGATCGAGGCCGAGGCGCTGTCGATTCCCGAGCAGTTGACCGTGTCCATCGAAGGTGCCGAACCAGGCACCCAGCTCACCGCCGGGCAGATCGCGCTGCCGGCCGGTGTCAGCCTGATTTCTGACCCTGATCTGTTGGTGGTCAACGTGGTGAAGGCGCCAACCGCCGAGGAGCTGGAGGGCGAAGTCGCAGGAGCCGAGGAAGCCGAGGAAGCCGCGGTAGAAGCCGGCGAAGCCGAGGCCGCTGGCGAGTCCGAGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. {ECO:0000255|HAMAP-Rule:MF_01334}.

Family

Bacterial ribosomal protein bL25 family, CTC subfamily

GO

cytosolic large ribosomal subunit GO:0022625 cellular_component
structural constituent of ribosome GO:0003735 molecular_function
cytosol GO:0005829 cellular_component
5S rRNA binding GO:0008097 molecular_function
translation GO:0006412 biological_process

InterPro

UniProt: P9WHB5
GenBank: Rv1015c
EnsemblBacteria: Rv1015c
Mycobrowser: Rv1015c

Summary

Name: 50S ribosomal protein L25 (General stress protein CTC)
Family: Bacterial ribosomal protein bL25 family, CTC subfamily
Protein Sequence: MAKSASNQLRVTVRTETGKGASRRARRAGKIPAVLYGHGAEPQHLELPGHDYAAVLRHSGTNAVLTLDIAGKEQLALTKALHIHPIRRTIQHADLLVVRRGEKVVVEVSVVVEGQAGPDTLVTQETNSIEIEAEALSIPEQLTVSIEGAEPGTQLTAGQIALPAGVSLISDPDLLVVNVVKAPTAEELEGEVAGAEEAEEAAVEAGEAEAAGESE
Mass: 22,441 Da
Length: 215 Aa

Rv1015c doesn't seem to be a targeted by any drug.

Ribosome mtu03010
mtu03010
PATHWAY_MAP mtu03010 Ribosome

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.