Function

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:19121323, ECO:0000269|PubMed:19237750}.

Family

N-acetylglucosamine-1-phosphate uridyltransferase family; Transferase hexapeptide repeat family

GO

• cell wall organization GO:0071555 biological_process
• glucosamine-1-phosphate N-acetyltransferase activity GO:0019134 molecular_function
• lipopolysaccharide biosynthetic process GO:0009103 biological_process
• magnesium ion binding GO:0000287 molecular_function
• entry of bacterium into host cell GO:0035635 biological_process
• cytoplasm GO:0005737 cellular_component
• regulation of cell shape GO:0008360 biological_process
• adhesion of symbiont to host cell GO:0044650 biological_process
• uridylyltransferase activity GO:0070569 molecular_function
• UDP-N-acetylglucosamine biosynthetic process GO:0006048 biological_process
• UDP-N-acetylglucosamine diphosphorylase activity GO:0003977 molecular_function
• cell morphogenesis GO:0000902 biological_process
• lipid A biosynthetic process GO:0009245 biological_process
• peptidoglycan biosynthetic process GO:0009252 biological_process

InterPro

• IPR005882
• IPR038009
• IPR001451
• IPR025877
• IPR029044
• IPR011004

UniProt

P9WMN3

GenBank

Rv1018c

EnsemblBacteria

Rv1018c

Mycobrowser

Rv1018c

Rv1018c doesn't seem to be a targeted by any drug.

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  Amino sugar and nucleotide sugar metabolism mtu00520

  mtu00520

  PATHWAY_MAP mtu00520 Amino sugar and nucleotide sugar metabolism