Rv1021
- Type
- protein_coding
- Name
- Rv1021
- Locus Name
-
Rv1021
- Product
-
Conserved protein
- Functional Category
-
Conserved hypotheticals
- Location
- 1142671..1143648 (+ strand)
- Gene Length
- 977 bp
- Nucleotides
-
TGATTGTCGTCCTGGTCGACCCCCGGCGTCCGACACTGGTGCCTGTTGAAGCGATCGAGTTCCTGCGCGGCGAGGTGCAATACACCGAGGAAATGCCGGTCGCGGTGCCCTGGTCGCTACCAGCGGCTCGTTCGGCGCACGCCGGAAACGACGCGCCGGTGTTGCTGTCGTCTGACCCCAACCATCCTGCTGTCATTACTCGACTGGCCGCCGGTGCCCGGCTGATCTCGGCACCGGATTCTCAGCGTGGCGAACGACTCGTCGACGCCGTCGCGATGATGGACAAGCTGCGCACCGCCGGACCGTGGGAAAGTGAGCAGACTCACGACTCGCTGCGCAGATACCTGCTGGAGGAGACCTACGAGCTGTTGGACGCGGTCCGCAGCGGCAGTGTTGACCAGCTGCGCGAAGAGCTTGGTGATCTCTTGCTGCAGGTCCTCTTTCACGCCCGGATCGCTGAGGATGCGTCGCAATCGCCGTTCACCATCGACGACGTCGCCGACACACTGATGCGAAAGCTCGGCAATCGGGCGCCAGGAGTACTTGCGGGCGAATCGATTTCGCTCGAAGATCAACTGGCGCAATGGGAGGCAGCCAAGGCCTCGGAAAAGGCGCGAAAGTCGGTAGCCGACGATGTCCATACGGGCCAGCCGGCATTAGCGCTGGCGCAGAAGGTTATTCAGCGTGCCCAAAAGGCTGGGCTGCCCGCTCACCTGATCCCCGATGAGATCACTTCTGTTTCGGTTTCAGCTGACGTAGATGCGGAAAACACGCTGCGCACTGCCGTTTTGGACTTTATTGACAGGCTGCGCTGTGCCGAGCGGGCAATTGCCGTCGCACGCCGGGGCAGCAACGTTGCCGAGCAGCTCGATGTGACGCCGCTGGGTGTGATCACCGAGCAGGAGTGGCTCGCGCATTGGCCAACTGCTGTCAACGATTCCCGCGGCGGGTCCAAGAAACGTAAAGGCATGCGATAA
- Drug Resistance
- Mutations
- Function
- Required to maintain the full capacity of the mycobacterium to respond to oxidative stress via the degradation of oxidation-induced damaged nucleotides. Hydrolyzes all canonical (d)NTPs, as well as mutagenic dUTP and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP). Also involved in the transcriptional activation of RelA in response to oxidative stress. {ECO:0000269|PubMed:20529853}.
- Family
-
Nucleoside triphosphate pyrophosphohydrolase family
- GO
-
- dUTP catabolic process GO:0046081 biological_process
- dTTP catabolic process GO:0046076 biological_process
- dATP catabolic process GO:0046061 biological_process
- magnesium ion binding GO:0000287 molecular_function
- UTP catabolic process GO:0046052 biological_process
- TTP catabolic process GO:0046047 biological_process
- cell wall GO:0005618 cellular_component
- ATP binding GO:0005524 molecular_function
- nucleoside-triphosphate diphosphatase activity GO:0047429 molecular_function
- ATP diphosphatase activity GO:0047693 molecular_function
- 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity GO:0035539 molecular_function
- dGTP catabolic process GO:0006203 biological_process
- response to oxidative stress GO:0006979 biological_process
- protein homotetramerization GO:0051289 biological_process
- InterPro
Summary
- Name
- Nucleoside triphosphate pyrophosphohydrolase (NTP-PPase) (EC 3.6.1.8)
- Family
- Nucleoside triphosphate pyrophosphohydrolase family
- Protein Sequence
-
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR
- Mass
- 35,413 Da
- Length
- 325 Aa
Rv1021 doesn't seem to be a targeted by any drug.
-
-
Purine metabolism mtu00230
mtu00230PATHWAY_MAP mtu00230 Purine metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Mycobacterial MazG is a novel NTP pyrophosphohydrolase involved in oxidative stress response.
- J Biol Chem. 2010 Sep 3;285(36):28076-85. doi: 10.1074/jbc.M109.088872. Epub 2010 Jun 7.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.