Gene - combatTB X

eno

Type: protein_coding
Name: eno
Locus Name: Rv1023
Product: Probable enolase Eno
Functional Category: Intermediary metabolism and respiration
Location: 1144564..1145853 (+ strand)
Gene Length: 1289 bp
Nucleotides: TGCCGATTATCGAGCAGGTTAGGGCCCGAGAGATCCTCGATTCCCGCGGCAACCCGACGGTGGAGGTCGAGGTGGCGCTTATCGACGGGACATTCGCCCGGGCCGCGGTGCCGTCGGGCGCCTCGACCGGGGAGCACGAGGCCGTCGAGTTGCGCGACGGCGGCGATCGCTACGGCGGCAAAGGCGTGCAAAAAGCCGTGCAGGCTGTTCTTGATGAGATCGGCCCGGCCGTCATCGGACTCAACGCCGACGACCAGCGATTGGTCGACCAGGCGCTGGTGGACCTAGACGGCACCCCCGACAAGTCCCGGCTGGGCGGCAACGCGATCTTGGGTGTCTCGCTCGCTGTTGCCAAGGCGGCGGCGGATTCGGCGGAGCTGCCGTTGTTCCGTTATGTCGGGGGGCCAAACGCGCACATTCTGCCGGTACCGATGATGAACATCCTCAACGGCGGCGCACACGCCGATACCGCTGTCGACATTCAAGAGTTCATGGTGGCGCCAATTGGCGCGCCCAGCTTCGTCGAGGCGTTGCGCTGGGGCGCTGAGGTGTACCACGCGCTCAAGTCGGTCCTGAAAAAGGAGGGGCTGTCCACCGGCCTGGGCGACGAAGGCGGCTTCGCCCCGGATGTGGCCGGCACCACCGCGGCGTTGGACCTGATCAGCCGGGCCATCGAGTCGGCGGGCTTGCGACCCGGCGCCGACGTGGCGCTGGCCCTGGACGCGGCGGCCACCGAGTTCTTCACCGACGGCACCGGCTACGTCTTCGAGGGCACCACCCGTACCGCAGACCAGATGACCGAGTTCTACGCGGGCCTGCTCGGCGCCTACCCGCTGGTGTCGATCGAAGACCCACTGTCCGAAGACGATTGGGACGGCTGGGCCGCGCTGACGGCCTCGATCGGTGACCGGGTGCAAATCGTCGGCGACGACATCTTTGTCACCAATCCCGAGCGGCTCGAGGAGGGCATCGAACGGGGCGTGGCAAATGCGTTGCTGGTCAAGGTGAACCAGATCGGGACGTTGACCGAGACACTCGACGCGGTCACGCTGGCTCACCACGGCGGATACCGCACGATGATCAGTCACCGCAGTGGCGAGACGGAGGACACCATGATCGCCGACCTCGCGGTGGCCATCGGCAGCGGGCAGATCAAGACGGGCGCGCCTGCTCGCAGTGAGCGCGTCGCAAAATACAACCAGCTGCTGCGGATCGAAGAGGCGCTTGGCGACGCGGCCCGCTACGCGGGCGACCTGGCATTTCCTCGGTTCGCGTGCGAGACGAAATAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. {ECO:0000255|HAMAP-Rule:MF_00318}.

Family

Enolase family

GO

phosphopyruvate hydratase activity GO:0004634 molecular_function
phosphopyruvate hydratase complex GO:0000015 cellular_component
plasma membrane GO:0005886 cellular_component
extracellular region GO:0005576 cellular_component
cell wall GO:0005618 cellular_component
glycolytic process GO:0006096 biological_process
magnesium ion binding GO:0000287 molecular_function
cell surface GO:0009986 cellular_component

InterPro

UniProt: P9WNL1
GenBank: Rv1023
EnsemblBacteria: Rv1023
Mycobrowser: Rv1023

Summary

Name: Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)
Family: Enolase family
Protein Sequence: MPIIEQVRAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDIQEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALALDAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERLEEGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYNQLLRIEEALGDAARYAGDLAFPRFACETK
Mass: 44,962 Da
Length: 429 Aa

Rv1023 doesn't seem to be a targeted by any drug.

Glycolysis / Gluconeogenesis mtu00010
mtu00010
Metabolism; Carbohydrate metabolism

Methane metabolism mtu00680
mtu00680
Metabolism; Energy metabolism

RNA degradation mtu03018
mtu03018
Genetic Information Processing; Folding, sorting and degradation

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.