Gene - combatTB X

kdpD

Type: protein_coding
Name: kdpD
Locus Name: Rv1028c
Product: Probable sensor protein KdpD
Functional Category: Regulatory proteins
Location: 1149104..1151686 (- strand)
Gene Length: 2582 bp
Nucleotides: GTGACGTTGCTCTTCGCCGATCTTTGCGCGATCTTTACGCCCTACCGGTGGATGATTGAGCATGTGACCACCAAGCGCGGGCAGCTGCGGATCTATCTGGGCGCGGCCCCCGGCGTGGGCAAAACCTACGCCATGCTCGGCGAGGCGCACCGCAGGCTGGAGCGCGGCACCGACGTGGTCGCCGCGGTCGTCGAGACACACGGACGCAACAAGACCGCGAAACTGCTCGAGGGCATCGAGATGATCCCGCCGCGCTACGTCGAATATCGGGGTGCCAGGTTTCCCGAACTCGATGTGGAGGCAGTACTGCGACGTCATCCTCAGGTGGTGCTGGTGGACGAACTCGCCCACACCAACACACCTGGCAGCAAGAACCCCAAGCGCTGGCAGGACGTTCAGGAAATCCTCGACGCCGGCATCACGGTGATCTCGACGGTCAACATCCAGCACTTGGAGGGCCTAAACGATGTCGTGGAGCAAATCACCGGCATCGAGCAGAAGGAGAAGATCCCCGACGAGATCGTCCGCGCGGCCGATCAGGTCGAGCTGGTCGACATCACACCGGAAGCGTTGCGGCGCAGGCTTGCTCACGGCAACGTCTATGCAGCCGAACGGGTCGATGCCGCGCTGTCGAACTACTTCCGCACGGGCAATCTGACCGCGCTGCGCGAGATCGCGTTGCTGTGGCTGGCCGACCAAGTTGATGCGGCCCTGGAGAAGTACCGCGCAGACAAAAAGATCACCGCCACGTGGGAGGCGCGGGAACGCGTCGTCGTCGCCGTGACCGGCGGCCCGGAGTCGGAGACGTTGGTGCGACGGGCATCGCGGATCGCGTCGAAGTCCAGCGCCGAGCTGATGGTGGTTCACGTTATCCGTGGCGACGGCCTGGCGGGGGTGTCCGCGCCGCAGCTGGGCAGGGTCCGCGAGCTGGCGACAAGCCTCGGTGCGACCATGCACACCGTGGTCGGCGACGACGTGCCCACCGCGCTGCTGGACTTCGCCCGCGAGATGAACGCCACGCAGCTCGTCGTCGGCACATCGCGGCGATCGCGATGGGCACGCCTGTTTGACGAGGGGATCGGCGCCCGCACCGTCCAGGAGCCCGGCGGCATCGACGTTCACATGGTCACCCATCCCGCGGCCAGCCGGGCCTCCGGGTGGTCGCGGGTCTCCCCGCGCGAGCGGCATATCGCGTCGTGGCTGGCCGCGCTGGTGGTGCCCTCGGTGATCTGCGCCATCACGGTGGCCTGGCTCGACCGATTCATGGGCATCGGCGGCGAGAGCGCGTTGTTCTTCATCGGCGTGCTGATCGTGGCGTTGCTGGGCGGCGTCGCCCCCGCCGCATTGTCGGCCTTGCTGTCGGGCATGCTGCTGAACTACTTTCTGACCGAGCCCCGCTACACCTGGACCATCGCCGAACCGGACGCCGCAGTAACCGAATTCGTGTTGTTGGCGATGGCCGTTGCGGTGGCGGTGTTGGTGGACGGCGCGGCTAGCCGAACCCGTGAGGCTCGGCGCGCATCCCAGGAGGCTGAGTTGCTGGCCCTGTTTGCCGGTTCGGTGTTGCGCGGCGCAGACCTTGCCACGCTGCTGCAGCGGGTCCGCGAAACGTATTCCCAACGGGCCGTGACCATGCTGCGTGTCCGGCAGGGCGCATCGACAGGCGAAACCGTCGCGTGCGTCGGGACAAACCCGTGTCGGGACGTCGACTCCGCCGACACCGCAATCGAAGTCGGCGACGACGAGTTTTGGATGCTGATGGCAGGCCGCAAGTTGGCCGCCCGCGACCGCCGAGTGCTGACCGCGGTCGCGACACAGGCCGCGGGTCTGGTGAAGCAGCGCGAGCTGGCGGAAGAGGCCGGCCAGGCCGAGGCCATCGCTAGGGCCGATGAGCTGCGCCGGTCGCTGCTGTCGGCGGTCAGCCACGACCTGCGCACCCCGCTGGCGGCGGCCAAGGTTGCGGTGTCCAGCTTGCGCACCGAAGACGTCGCTTTCTCCCCCGAGGATACCGCCGAGCTGTTGGCCACCATCGAGGAGTCCATCGACCAACTCACCGCCCTGGTCGCAAACCTGCTCGATTCGTCGCGGTTGGCTGCCGGCGTGATTCGCCCCCAGCTGCGCCGGGCATACCTGGAGGAAGCGGTGCAACGGGCCTTGGTCAGCATCGGCAAGGGCGCCACCGGTTTTTACCGATCCGGCATCGACCGGGTCAAGGTCGACGTGGGAGACGCCGTGGCGATGGCCGACGCCGGGTTGCTGGAGCGGGTGCTAGCCAACCTGATCGACAACGCGCTGCGATATGCGCCCGACTGCGTGGTCCGGGTCAACGCGGGACGGGTGCGTGAGCGGGTCCTGATTAATGTCATCGACGAGGGCCCAGGGGTCCCGCGCGGGACCGAGGAGCAACTCTTTGCCCCGTTCCAGCGGCCGGGGGATCACGACAACACCACCGGTGTCGGTCTGGGGATGTCGGTGGCACGCGGCTTCGTCGAGGCTATGGGCGGCACGATTTCGGCTACCGATACCCCGGGCGGCGGGCTCACAGTGGTGATCGATCTGGCGGCTCCCGAGGACCGCCCATG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals (By similarity). {ECO:0000250}.

Family

Universal stress protein A family

GO

detection of chemical stimulus GO:0009593 biological_process
ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component
phosphorelay sensor kinase activity GO:0000155 molecular_function
cytoplasm GO:0005737 cellular_component

InterPro

UniProt: P9WGL3
GenBank: Rv1028c
EnsemblBacteria: Rv1028c
Mycobrowser: Rv1028c

Summary

Name: Sensor protein KdpD (EC 2.7.13.3)
Family: Universal stress protein A family
Protein Sequence: MTLLFADLCAIFTPYRWMIEHVTTKRGQLRIYLGAAPGVGKTYAMLGEAHRRLERGTDVVAAVVETHGRNKTAKLLEGIEMIPPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDGLAGVSAPQLGRVRELATSLGATMHTVVGDDVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGARTVQEPGGIDVHMVTHPAASRASGWSRVSPRERHIASWLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVACVGTNPCRDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLSAVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALVSIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVNAGRVRERVLINVIDEGPGVPRGTEEQLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP
Mass: 92,749 Da
Length: 860 Aa

Rv1028c doesn't seem to be a targeted by any drug.

Two-component system mtu02020
mtu02020
Environmental Information Processing; Signal transduction

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family.: Mol Microbiol. 2003 Feb;47(4):1075-89.
Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis.: Infect Immun. 2003 Mar;71(3):1134-40. doi: 10.1128/iai.71.3.1134-1140.2003.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.