Gene - combatTB X

PPE15

Type: protein_coding
Name: PPE15
Locus Name: Rv1039c
Product: PPE family protein PPE15
Functional Category: Pe/ppe
Location: 1161297..1162472 (- strand)
Gene Length: 1175 bp
Nucleotides: ATGGATTTCGGAGCTTTACCCCCTGAGATCAACTCCGCACGCATGTACGCCGGCGCGGGTGCAGGACCGATGATGGCCGCCGGGGCCGCATGGAACGGCCTGGCCGCCGAGTTGGGTACGACGGCCGCGTCGTATGAGTCGGTGATCACCCGGCTGACCACCGAGTCGTGGATGGGTCCGGCCTCGATGGCGATGGTCGCCGCAGCCCAGCCCTATCTGGCTTGGTTGACCTACACCGCCGAAGCCGCTGCGCATGCCGGCTCGCAGGCCATGGCGTCGGCGGCCGCCTACGAGGCGGCCTATGCGATGACAGTGCCGCCGGAGGTGGTCGCGGCCAACCGGGCGCTGCTGGCGGCCCTGGTCGCGACGAACGTCCTGGGGATCAACACACCGGCAATCATGGCGACCGAAGCCCTCTATGCCGAGATGTGGGCTCAGGACGCTCTGGCTATGTACGGCTACGCGGCCGCTTCGGGAGCCGCCGGGATGCTGCAACCGTTAAGCCCGCCGTCGCAGACCACCAACCCGGGCGGGCTGGCCGCCCAGTCCGCCGCGGTCGGCTCGGCTGCCGCCACCGCCGCCGTCAACCAGGTGAGCGTAGCGGACCTGATCAGTAGCCTGCCCAACGCGGTGAGTGGGCTCGCCTCCCCAGTCACATCGGTTCTCGACTCGACGGGGCTGAGCGGAATCATTGCCGACATCGACGCCCTGCTCGCGACCCCGTTCGTGGCAAACATCATCAACAGCGCAGTCAACACCGCCGCTTGGTATGTCAACGCCGCCATCCCCACCGCGATATTCCTAGCAAATGCCCTGAACAGTGGGGCGCCGGTAGCGATCGCCGAAGGCGCCATCGAGGCTGCCGAGGGTGCCGCCAGTGCGGCCGCCGCGGGGTTGGCGGACTCGGTGACGCCAGCGGGGCTCGGCGCAAGTTTAGGCGAGGCCACCCTGGTCGGCCGGCTGTCAGTGCCGGCGGCCTGGTCTACGGCCGCACCGGCGACAACCGCCGGCGCCACAGCGCTCGAAGGCAGCGGCTGGACCGTCGCCGCCGAAGAAGCCGGCCCAGTTACCGGGATGATGCCGGGAATGGCCTCGGCCGCCAAGGGCACCGGTGCCTATGCCGGGCCGCGGTACGGATTCAAGCCCACTGTCATGCCCAAACAGGTCGTCGTGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

May play a critical role in the homeostasis of triacylglycerol-containing lipid droplets in M.tuberculosis and influence the entry of the pathogen into a dormant state. {ECO:0000269|PubMed:27325376}.

Family

Mycobacterial PPE family

GO

neutral lipid metabolic process GO:0006638 biological_process
acyl-CoA metabolic process GO:0006637 biological_process
membrane lipid metabolic process GO:0006643 biological_process
triglyceride mobilization GO:0006642 biological_process
phospholipid metabolic process GO:0006644 biological_process
triglyceride metabolic process GO:0006641 biological_process
monoacylglycerol biosynthetic process GO:0006640 biological_process
2-hydroxyquinoline 5,6-dioxygenase activity GO:0018629 molecular_function
2-aminobenzenesulfonate 2,3-dioxygenase activity GO:0018627 molecular_function
terephthalate 1,2-dioxygenase activity GO:0018628 molecular_function
naphthalene 1,2-dioxygenase activity GO:0018625 molecular_function
2-chlorobenzoate 1,2-dioxygenase activity GO:0018626 molecular_function
NLS-bearing protein import into nucleus GO:0006607 biological_process
protein import into nucleus GO:0006606 biological_process
obsolete mRNA-binding (hnRNP) protein import into nucleus GO:0006609 biological_process
obsolete snRNP protein import into nucleus GO:0006608 biological_process
phosphocreatine metabolic process GO:0006603 biological_process
creatinine catabolic process GO:0006602 biological_process
protein targeting GO:0006605 biological_process
creatine metabolic process GO:0006600 biological_process
creatine biosynthetic process GO:0006601 biological_process
protein export from nucleus GO:0006611 biological_process
protein targeting to membrane GO:0006612 biological_process
ribosomal protein import into nucleus GO:0006610 biological_process
phosphoarginine metabolic process GO:0006604 biological_process

InterPro

UniProt: P9WI31
GenBank: Rv1039c
EnsemblBacteria: Rv1039c
Mycobrowser: Rv1039c

Summary

Name: PPE family protein PPE15 (Mycobacterial perilipin-1) (MPER1)
Family: Mycobacterial PPE family
Protein Sequence: MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAELGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAGSQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATEALYAEMWAQDALAMYGYAAASGAAGMLQPLSPPSQTTNPGGLAAQSAAVGSAAATAAVNQVSVADLISSLPNAVSGLASPVTSVLDSTGLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAIPTAIFLANALNSGAPVAIAEGAIEAAEGAASAAAAGLADSVTPAGLGASLGEATLVGRLSVPAAWSTAAPATTAGATALEGSGWTVAAEEAGPVTGMMPGMASAAKGTGAYAGPRYGFKPTVMPKQVVV
Mass: 38,081 Da
Length: 391 Aa

Rv1039c doesn't seem to be a targeted by any drug.

Rv1039c doesn't seem to be involved in any pathway.

The perilipin-like PPE15 protein in Mycobacterium tuberculosis is required for triacylglycerol accumulation under dormancy-inducing conditions.: Mol Microbiol. 2016 Sep;101(5):784-94. doi: 10.1111/mmi.13422. Epub 2016 Jun 21.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.