fum
- Type
- protein_coding
- Name
- fum
- Locus Name
-
Rv1098c
- Product
-
Probable fumarase Fum (fumarate hydratase)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1226141..1227565 (- strand)
- Gene Length
- 1424 bp
- Nucleotides
-
ATGGCCGTTGACGCCGACAGCGCCAATTACCGCATCGAGCACGACACCATGGGCGAAGTCCGGGTGCCGGCAAAAGCGTTGTGGCGCGCGCAAACCCAGCGCGCGGTGGAGAACTTCCCGATATCCGGCCGCGGGTTGGAGCGCACCCAGATCCGCGCGCTAGGCCTGCTGAAAGGCGCCTGCGCGCAGGTGAACTCCGACCTCGGGTTGCTGGCGCCGGAGAAAGCCGACGCCATCATCGCCGCGGCCGCCGAGATCGCCGACGGTCAACACGACGACCAGTTTCCCATCGACGTCTTCCAGACCGGCTCGGGCACCAGCTCCAACATGAACACCAACGAGGTGATTGCGTCCATCGCGGCCAAGGGCGGGGTCACGTTGCATCCCAACGACGACGTGAACATGTCGCAGTCGTCCAACGACACCTTCCCGACGGCCACCCACATCGCGGCCACCGAGGCCGCGGTCGCTCATCTCATCCCAGCGCTGCAGCAGCTGCACGACGCATTGGCCGCCAAGGCTCTTGATTGGCACACGGTGGTGAAGTCGGGCCGAACGCATCTGATGGACGCCGTTCCGGTGACACTCGGCCAGGAGTTCAGCGGATATGCCCGCCAGATCGAGGCCGGCATCGAGCGGGTGCGCGCGTGTCTGCCCAGGCTGGGCGAGCTGGCGATCGGCGGCACCGCGGTGGGTACCGGCCTCAACGCTCCCGACGACTTCGGCGTCAGAGTGGTCGCGGTGCTGGTCGCGCAGACCGGTCTGTCGGAATTGCGTACGGCGGCTAATTCTTTCGAAGCTCAGGCTGCCCGCGACGGGCTGGTGGAGGCGTCCGGGGCGCTGCGCACGATCGCGGTATCGCTGACCAAGATCGCCAACGACATCCGCTGGATGGGATCGGGCCCATTGACCGGCCTGGCCGAGATCCAACTGCCAGATCTGCAGCCGGGCAGCTCGATCATGCCGGGAAAGGTGAATCCGGTTCTGCCGGAGGCGGTTACGCAGGTCGCCGCGCAGGTGATCGGAAACGACGCCGCCATCGCCTGGGGTGGGGCCAACGGCGCATTCGAACTCAACGTCTACATCCCGATGATGGCCCGCAACATCCTCGAGTCCTTCAAGCTGCTGACCAATGTGTCACGGCTGTTCGCCCAGCGCTGCATAGCAGGGCTGACCGCCAACGTCGAGCACCTGCGGCGGCTGGCCGAGTCCTCACCGTCGATCGTGACACCGTTGAATTCGGCCATCGGCTACGAGGAGGCGGCCGCCGTCGCCAAGCAAGCACTCAAGGAACGCAAAACGATTCGCCAAACCGTGATCGACCGTGGCCTGATCGGCGACAGGCTGTCGATCGAGGATCTGGACCGCCGTCTGGACGTGCTGGCAATGGCCAAGGCCGAGCAGCTCGACAGCGATCGGCTATG
- Drug Resistance
- Mutations
- Function
- Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate. {ECO:0000255|HAMAP-Rule:MF_00743, ECO:0000305|PubMed:27325754}.
- Family
-
Class-II fumarase/aspartase family, Fumarase subfamily
- GO
-
- tricarboxylic acid cycle GO:0006099 biological_process
- fumarate metabolic process GO:0006106 biological_process
- cell wall GO:0005618 cellular_component
- extracellular region GO:0005576 cellular_component
- cytosol GO:0005829 cellular_component
- plasma membrane GO:0005886 cellular_component
- tricarboxylic acid cycle enzyme complex GO:0045239 cellular_component
- fumarate hydratase activity GO:0004333 molecular_function
- InterPro
3NO9
- Name
- Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) (Aerobic fumarase) (Iron-independent fumarase)
- Family
- Class-II fumarase/aspartase family, Fumarase subfamily
- Protein Sequence
-
MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
- Mass
- 50,141 Da
- Length
- 474 Aa
Summary
Rv1098c doesn't seem to be a targeted by any drug.
-
-
Pyruvate metabolism mtu00620
mtu00620PATHWAY_MAP mtu00620 Pyruvate metabolism
-
-
-
Citrate cycle (TCA cycle) mtu00020
mtu00020Metabolism; Carbohydrate metabolism
-
- Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
- Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7503-8. doi: 10.1073/pnas.1600630113. Epub 2016 Jun 20.
- Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
- FEBS Lett. 2012 Jun 4;586(11):1606-11. doi: 10.1016/j.febslet.2012.04.034. Epub 2012 May 3.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.