lytB2
- Type
- protein_coding
- Name
- lytB2
- Locus Name
-
Rv1110
- Product
-
Probable LYTB-related protein LytB2
- Functional Category
-
Cell wall and cell processes
- Location
- 1236185..1237192 (+ strand)
- Gene Length
- 1007 bp
- Nucleotides
-
TGGTTCCGACGGTCGACATGGGGATTCCCGGGGCTTCGGTATCGTCGCGATCGGTGGCCGACCGTCCCAACCGTAAGCGGGTGCTGCTGGCCGAGCCGCGTGGCTACTGCGCTGGCGTGGATCGGGCCGTCGAAACGGTCGAACGCGCGCTTCAAAAACACGGCCCGCCTGTCTACGTGCGTCACGAGATCGTGCATAACCGCCACGTGGTTGACACCCTGGCTAAGGCCGGTGCGGTTTTCGTCGAAGAGACCGAGCAGGTTCCCGAGGGAGCGATTGTGGTGTTCTCCGCGCACGGGGTCGCGCCTACGGTGCACGTCAGCGCCAGCGAGCGCAACCTGCAGGTCATTGACGCCACCTGCCCGCTGGTCACCAAGGTGCACAACGAGGCCAGGCGGTTCGCCCGGGACGACTACGACATCTTGCTGATCGGTCATGAGGGCCACGAGGAAGTCGTCGGTACTGCTGGGGAAGCTCCCGATCATGTGCAGCTGGTCGACGGGGTGGACGCCGTCGACCAGGTGACCGTCCGTGACGAGGACAAAGTGGTTTGGCTGTCGCAGACCACCCTGTCCGTCGATGAGACCATGGAGATTGTCGGGCGGTTGCGTCGGCGTTTCCCCAAGCTGCAGGATCCGCCCAGCGACGACATCTGCTATGCGACCCAGAATCGGCAGGTCGCGGTCAAGGCGATGGCGCCCGAGTGCGAGCTGGTCATCGTGGTCGGCTCGCGCAATTCGTCGAATTCGGTTCGGCTGGTCGAGGTGGCGCTGGGTGCCGGGGCGCGGGCCGCCCACCTGGTGGACTGGGCCGACGATATCGACTCGGCCTGGCTGGACGGCGTTACCACGGTCGGCGTTACGTCGGGGGCATCGGTCCCCGAGGTGCTGGTGCGCGGTGTGCTGGAGCGGCTGGCCGAATGCGGCTACGACATCGTGCAACCGGTGACAACGGCCAACGAGACGTTGGTGTTCGCATTGCCCCGGGAGCTCCGCTCACCTCGCTGA
- Drug Resistance
- Mutations
- Function
- Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (PubMed:23091471). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Has a higher activity compared with LytB2 (PubMed:23091471). Is essential for M.tuberculosis growth in vitro (PubMed:26309039). {ECO:0000255|HAMAP-Rule:MF_00191, ECO:0000269|PubMed:23091471, ECO:0000269|PubMed:26309039}.
- Family
-
IspH family
- GO
-
- isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway GO:0019288 biological_process
- metal ion binding GO:0046872 molecular_function
- 4 iron, 4 sulfur cluster binding GO:0051539 molecular_function
- dimethylallyl diphosphate biosynthetic process GO:0050992 biological_process
- 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity GO:0051745 molecular_function
- terpenoid biosynthetic process GO:0016114 biological_process
- InterPro
Summary
- Name
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 2 (HDR 2) (HMBPP reductase 2) (EC 1.17.7.4)
- Family
- IspH family
- Protein Sequence
-
MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAVETVERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVFSAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR
- Mass
- 36,297 Da
- Length
- 335 Aa
Rv1110 doesn't seem to be a targeted by any drug.
-
-
Terpenoid backbone biosynthesis mtu00900
mtu00900Metabolism; Metabolism of terpenoids and polyketides
-
- LytB1 and LytB2 of Mycobacterium tuberculosis Are Not Genetically Redundant.
- PLoS One. 2015 Aug 26;10(8):e0135638. doi: 10.1371/journal.pone.0135638. eCollection 2015.
- Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related Mycobacteria.
- Front Microbiol. 2012 Oct 12;3:368. doi: 10.3389/fmicb.2012.00368. eCollection 2012.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.