pimE
- Type
- protein_coding
- Name
- pimE
- Locus Name
-
Rv1159
- Product
-
Mannosyltransferase PimE
- Functional Category
-
Cell wall and cell processes
- Location
- 1284992..1286287 (+ strand)
- Gene Length
- 1295 bp
- Nucleotides
-
TGTGCCGCACCCTGATCGACGGCCCGGTGCGCTCGGCGATCGCTAAAGTCAGGCAGATAGACACCACCTCATCCACCCCGGCGGCCGCCAGGCGCGTGACCTCACCACCGGCCCGGGAGACACGCGCCGCCGTGCTGCTACTGGTCCTCAGCGTCGGTGCGCGACTCGCCTGGACCTATCTGGCGCCCAACGGCGCAAACTTCGTCGACCTGCACGTTTACGTGAGCGGTGCAGCGTCCCTCGACCATCCCGGCACCCTGTATGGCTACGTCTACGCTGATCAGACCCCGGACTTCCCGCTGCCGTTCACCTATCCGCCGTTTGCGGCTGTGGTCTTCTACCCGTTGCATTTGGTGCCGTTCGGTCTGATCGCGCTGCTGTGGCAAGTAGTGACGATGGCCGCGCTCTACGGCGCGGTTCGGATCAGCCAGCGCCTGATGGGGGGCACCGCTGAGACCGGTCATTTCGCCGCGATGTTATGGACGGCGATCGCCATCTGGATCGAGCCGTTGCGCAGCACCTTTGACTATGGGCAGATCAACGTGCTGCTGATGCTGGCGGCGCTTTGGGCGGTCTACACCCCGCGGTGGTGGCTATCGGGACTGCTGGTCGGGGTGGCCTCGGGTGTCAAGTTGACGCCGGCGATTACCGCTGTCTACCTCGTCGGCGTTCGGCGGTTGCATGCGGCCGCATTTTCGGTGGTCGTGTTCCTTGCCACCGTCGGCGTGTCGCTACTGGTCGTCGGCGATGAAGCCCGCTACTACTTCACCGACCTGTTGGGCGACGCAGGCCGGGTTGGGCCCATCGCCACCTCCTTCAATCAATCCTGGCGCGGCGCGATTTCCCGGATTCTCGGTCACGACGCCGGTTTTGGTCCGCTGGTTCTGGCTGCGATCGCCAGTACGGCGGTATTGGCCATCCTGGCCTGGCGTGCGCTCGACAGGTCCGATCGGCTGGGCAAACTATTGGTGGTCGAGTTGTTCGGCCTGCTGCTCTCGCCGATCTCCTGGACTCACCACTGGGTGTGGCTAGTGCCGCTGATGATCTGGCTGATTGACGGGCCAGCGCGTGAGCGCCCGGGCGCCCGGATTTTGGGCTGGGGCTGGTTGGTGTTGACCATCGTCGGCGTGCCGTGGTTGCTGAGCTTTGCTCAACCGAGCATCTGGCAAATCGGCCGGCCGTGGTATTTGGCCTGGGCCGGTCTGGTCTACGTGGTGGCGACGCTGGCGACCTTGGGCTGGATCGCCGCCTCCGAGCGTTACGTGCGCATTCGGCCGCGGCGCATGGCCAATTAG
- Drug Resistance
- Mutations
- Function
- Catalyzes the alpha-1,2 addition of a mannose residue from polyprenol-phosphate-mannose (PPM) to a monoacyl phosphatidylinositol pentamannoside (AcPIM5) to generate a monoacyl phosphatidylinositol hexamannoside (AcPIM6). {ECO:0000269|PubMed:16803893}.
- Family
-
Glycosyltransferase 87 family
- GO
-
- phosphatidylinositol metabolic process GO:0046488 biological_process
- pathogenesis GO:0009405 biological_process
- glycolipid biosynthetic process GO:0009247 biological_process
- phospholipid biosynthetic process GO:0008654 biological_process
- plasma membrane GO:0005886 cellular_component
- GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity GO:0004377 molecular_function
- phosphatidylinositol alpha-mannosyltransferase activity GO:0043750 molecular_function
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Polyprenol-phosphate-mannose-dependent alpha-(1-2)-phosphatidylinositol pentamannoside mannosyltransferase (EC 2.4.1.-) (Alpha-mannosyltransferase) (Alpha-ManT) (PPM-dependent mannosyltransferase) (Polyprenol-phosphate-mannose alpha-mannosyltransferase) (PPM alpha-mannosyltransferase)
- Family
- Glycosyltransferase 87 family
- Protein Sequence
-
MCRTLIDGPVRSAIAKVRQIDTTSSTPAAARRVTSPPARETRAAVLLLVLSVGARLAWTYLAPNGANFVDLHVYVSGAASLDHPGTLYGYVYADQTPDFPLPFTYPPFAAVVFYPLHLVPFGLIALLWQVVTMAALYGAVRISQRLMGGTAETGHFAAMLWTAIAIWIEPLRSTFDYGQINVLLMLAALWAVYTPRWWLSGLLVGVASGVKLTPAITAVYLVGVRRLHAAAFSVVVFLATVGVSLLVVGDEARYYFTDLLGDAGRVGPIATSFNQSWRGAISRILGHDAGFGPLVLAAIASTAVLAILAWRALDRSDRLGKLLVVELFGLLLSPISWTHHWVWLVPLMIWLIDGPARERPGARILGWGWLVLTIVGVPWLLSFAQPSIWQIGRPWYLAWAGLVYVVATLATLGWIAASERYVRIRPRRMAN
- Mass
- 47,102 Da
- Length
- 431 Aa
Rv1159 doesn't seem to be a targeted by any drug.
-
-
Lipoarabinomannan (LAM) biosynthesis mtu00571
mtu00571Metabolism; Glycan biosynthesis and metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria.
- J Biol Chem. 2006 Sep 1;281(35):25143-55. doi: 10.1074/jbc.M604214200. Epub 2006 Jun 27.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.