Gene - combatTB X

lpqW

Type: protein_coding
Name: lpqW
Locus Name: Rv1166
Product: Probable conserved lipoprotein LpqW
Functional Category: Cell wall and cell processes
Location: 1296152..1298059 (+ strand)
Gene Length: 1907 bp
Nucleotides: TGGGCGTGCCCAGCCCAGTCCGCCGCGTCTGTGTGACGGTCGGCGCGTTGGTCGCGCTGGCGTGTATGGTGTTGGCCGGGTGCACGGTCAGCCCGCCGCCGGCACCCCAGAGCACTGATACGCCGCGCAGCACACCGCCCCCGCCGCGCCGCCCTACCCAGATCATCATGGGCATCGACTGGATCGGCCCCGGGTTCAACCCGCATTTGCTGTCCGACCTGTCGCCGGTGAACGCCGCAATCAGTGCGTTGGTGTTGCCCAGCGCGTTCCGGCCGATTCCGGATCCCAACACGCCGACCGGTTCGCGCTGGGAGATGGACCCGACCCTGTTGGTTTCCGCCGACGTGACCAACAACCACCCGTTCACGGTGACCTACAAGATCCGGCCCGAGGCGCAGTGGACGGACAACGCCCCGATCGCCGCCGACGACTTCTGGTATCTGTGGCAGCAGATGGTCACACAGCCGGGCGTCGTCGACCCCGCCGGATACCACCTGATCACCAGTGTCCAGTCGCTCGAGGGCGGTAAGCAGGCCGTCGTTACGTTCGCACAGCCCTACCCCGCTTGGCGTGAGTTGTTCACCGACATCCTGCCGGCGCACATCGTCAAGGACATACCAGGGGGCTTCGCGTCCGGTTTGGCTCGAGCGCTGCCGGTGACAGGTGGACAGTTTCGGGTGGAAAACATCGACCCACAGCGCGATGAGATCCTGATCGCCCGCAATGACCGTTACTGGGGCCCACCTTCCAAACCCGGCATCATTCTCTTCCGCCGGGCCGGGGCGCCGGCCGCGCTGGCCGATTCGGTACGTAACGGAGACACCCAGGTCGCCCAGGTGCATGGTGGCTCGGCGGCCTTCGCCCAGTTGTCGGCCATCCCCGACGTGCGGACCGCCCGGATCGTGACACCGCGGGTCATGCAGTTCACGCTGCGGGCAAACGTTCCCAAGCTGGCCGACACCCAGGTTCGCAAGGCGATTTTGGGGTTGCTGGACGTGGACCTACTTGCCGCCGTGGGCGCCGGCACCGACAACACCGTCACCTTGGACCAGGCGCAGATTCGTTCGCCGAGTGACCCGGGTTATGTTCCGACCGCGCCTCCCGCAATGAGCAGCGCCGCCGCGCTGGGTCTGCTGGAGGCATCGGGATTCCAGGTCGACACCAACACGTCGGTGTCGCCGGCGCCGTCGGTCCCCGATTCGACGACCACGTCGGTGAGCACCGGGCCGCCGGAAGTCATCCGCGGCCGGATCAGCAAGGACGGCGAACAGTTAACGCTGGTCATCGGGGTGGCCGCGAACGATCCGACCTCGGTGGCGGTCGCCAACACTGCTGCCGACCAGCTGCGCGACGTCGGCATCGCCGCGACTGTGCTGGCGTTAGACCCGGTCACGCTCTATCACGACGCGCTGAACGACAATCGGGTAGACGCCATTGTGGGCTGGCGCCAAGCCGGCGGAAACCTGGCGACGCTGCTGGCCTCTCGTTACGGCTGTCCCGCATTGCAGGCGACGACGGTCCCGGCTGCGAATGCGCCGACGACGGCCCCGTCCGCTCCCATTGGCCCTACGCCGTCCGCCGCGCCCGACACCGCGACACCGCCACCAACGGCGCCGCGCCGCCCATCCGACCCGGGCGCGCTGGTAAAAGCGCCGTCGAATCTCACCGGCATCTGCGACCGCAGCATCCAGTCGAACATCGATGCCGCACTCAATGGCACCAAGAACATCAACGACGTGATCACCGCGGTCGAACCGCGACTGTGGAATATGTCGACCGTGTTGCCGATCCTGCAGGACACCACGATCGTCGCGGCCGGCCCGAGCGTGCAGAACGTCAGCCTGTCTGGTGCGGTGCCAGTGGGCATCGTCGGCGACGCCGGCCAATGGGTGAAGACCGGGCAATAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

May directly or indirectly regulate the accessibility of the key branch point intermediate, monoacyl phosphatidylinositol tetramannoside (AcPIM4), to the elongating alpha-1,6 mannosyltransferases which could regulate the lipoarabinomannans (LAMs) biosynthesis. {ECO:0000250}.

Family

Bacterial solute-binding protein 5 family

GO

phosphatidylinositol metabolic process GO:0046488 biological_process
pathogenesis GO:0009405 biological_process
glycolipid biosynthetic process GO:0009247 biological_process
peptide transmembrane transporter activity GO:1904680 molecular_function
outer membrane-bounded periplasmic space GO:0030288 cellular_component
phospholipid biosynthetic process GO:0008654 biological_process
extracellular region GO:0005576 cellular_component

InterPro

UniProt: P9WGU7
GenBank: Rv1166
EnsemblBacteria: Rv1166
Mycobrowser: Rv1166

Summary

Name: Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW
Family: Bacterial solute-binding protein 5 family
Protein Sequence: MGVPSPVRRVCVTVGALVALACMVLAGCTVSPPPAPQSTDTPRSTPPPPRRPTQIIMGIDWIGPGFNPHLLSDLSPVNAAISALVLPSAFRPIPDPNTPTGSRWEMDPTLLVSADVTNNHPFTVTYKIRPEAQWTDNAPIAADDFWYLWQQMVTQPGVVDPAGYHLITSVQSLEGGKQAVVTFAQPYPAWRELFTDILPAHIVKDIPGGFASGLARALPVTGGQFRVENIDPQRDEILIARNDRYWGPPSKPGIILFRRAGAPAALADSVRNGDTQVAQVHGGSAAFAQLSAIPDVRTARIVTPRVMQFTLRANVPKLADTQVRKAILGLLDVDLLAAVGAGTDNTVTLDQAQIRSPSDPGYVPTAPPAMSSAAALGLLEASGFQVDTNTSVSPAPSVPDSTTTSVSTGPPEVIRGRISKDGEQLTLVIGVAANDPTSVAVANTAADQLRDVGIAATVLALDPVTLYHDALNDNRVDAIVGWRQAGGNLATLLASRYGCPALQATTVPAANAPTTAPSAPIGPTPSAAPDTATPPPTAPRRPSDPGALVKAPSNLTGICDRSIQSNIDAALNGTKNINDVITAVEPRLWNMSTVLPILQDTTIVAAGPSVQNVSLSGAVPVGIVGDAGQWVKTGQ
Mass: 66,130 Da
Length: 635 Aa

Rv1166 doesn't seem to be a targeted by any drug.

Rv1166 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.