papA3
- Type
- protein_coding
- Name
- papA3
- Locus Name
-
Rv1182
- Product
-
Probable conserved polyketide synthase associated protein PapA3
- Functional Category
-
Lipid metabolism
- Location
- 1320035..1321453 (+ strand)
- Gene Length
- 1418 bp
- Nucleotides
-
TGTTGCGGGTTGGACCGTTGACAATAGGCACGCTGGACGACTGGGCGCCGAGCACGGGTTCGACTGTGTCATGGCGACCTTCGGCTGTCGCGCACACGAAAGCGTCGCAGGCGCCGATCAGCGATGTTCCGGTCAGTTATATGCAGGCGCAACATATTCGGGGCTATTGCGAGCAAAAGGCAAAGGGACTCGACTACTCGCGGTTGATGGTCGTCAGCTGCCAGCAGCCCGGCCAGTGCGATATCCGGGCGGCCAACTACGTGATCAACGCCCATCTCCGACGGCACGATACCTATCGCAGCTGGTTCCAATACAACGGCAACGGACAAATAATCCGGCGTACGATCCAGGATCCCGCCGACATCGAGTTCGTACCAGTTCATCATGGTGAGCTCACGCTGCCGCAAATTCGCGAGATCGTGCAGAACACGCCGGATCCCCTGCAATGGGGTTGTTTTCGGTTTGGGATCGTGCAAGGCTGCGACCATTTCACATTCTTTGCAAGTGTGGATCATGTGCATGTGGACGCGATGATCGTCGGTGTCACGCTCATGGAGTTCCACCTGATGTACGCAGCGCTGGTGGGCGGCCATGCCCCTCTCGAGCTACCGCCGGCAGGCAGCTACGACGACTTCTGCCGCCGACAACACACGTTCAGCTCCACCCTCACGGTGGAGTCGCCCCAGGTTCGCGCCTGGACGAAGTTCGCCGAAGGTACTAACGGTAGCTTTCCTGATTTTCCACTCCCACTTGGTGACCCATCGAAACCCAGTGACGCGGATATTGTCACCGTGATGATGCTCGATGAAGAGCAGACGGCTCAATTCGAGTCCGTCTGCACGGCTGCCGGCGCTCGGTTCATCGGTGGCGTACTAGCCTGCTGCGGCCTGGCTGAACACGAGTTGACCGGTACGACAACCTATTACGGACTAACGCCGCGCGACACGCGCCGCACTCCAGCGGATGCCATGACCCAAGGTTGGTTCACCGGCCTAATTCCGATCACCGTCCCCATCGCCGGCTCGGCGTTCGGCGATGCCGCCCGAGCCGCGCAGACCTCGTTCGACTCGGGCGTGAAGCTCGCCGAAGTACCCTACGACCGCGTCGTCGAATTGTCGTCCACGCTAACCATGCCACGACCGAACTTTCCCGTCGTCAACTTCCTCGACGCAGGCGCGGCTCCGCTTTCGGTACTGCTCACCGCGGAGTTAACCGGTACGAACATAGGAGTGTACAGCGACGGTCGCTACTCTTATCAACTGTCCATCTACGTCATCCGCGTCGAGCAGGGGACGGCAGTGGCGGTCATGTTCCCCGACAACCCGATCGCCCGGGAATCGGTTGCCCGCTACCTGGCAACGCTGAAGTCTGTGTTCCAACGAGTCGCCGAGAGCGGGCAGCAGCAGAATGTTGCCTGA
- Drug Resistance
- Mutations
- Function
- Involved in the biosynthesis of polyacyltrehalose (PAT) which could have a role in anchoring the bacterial capsule. In vitro catalyzes the sequential transfer of two palmitoyl groups onto a single glucose residue of trehalose generating the diacylated product 2,3-diacyltrehalose (trehalose dipalmitate). Although palmitoyl-CoA (PCoA) seems to be the physiological acyl donor, PapA3 can also use docosanoyl (22-carbon saturated fatty acid) coenzyme A as acyl donor. {ECO:0000269|PubMed:19276083}.
- Family
-
PapA acyltransferase family
- GO
-
- glycolipid biosynthetic process GO:0009247 biological_process
- trehalose metabolic process GO:0005991 biological_process
- palmitoyltransferase activity GO:0016409 molecular_function
- InterPro
Summary
- Name
- Acyltransferase papA3 (EC 2.3.1.-) (Polyketide synthase-associated protein A3)
- Family
- PapA acyltransferase family
- Protein Sequence
-
MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYMQAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDTYRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLPQIREIVQNTPDPLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVGGHAPLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFGDAARAAQTSFDSGVKLAEVPYDRVVELSSTLTMPRPNFPVVNFLDAGAAPLSVLLTAELTGTNIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFPDNPIARESVARYLATLKSVFQRVAESGQQQNVA
- Mass
- 51,575 Da
- Length
- 472 Aa
Rv1182 doesn't seem to be a targeted by any drug.
Rv1182 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.
- J Biol Chem. 2009 May 8;284(19):12745-51. doi: 10.1074/jbc.M809088200. Epub 2009 Mar 10.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.