sigI
- Type
- protein_coding
- Name
- sigI
- Locus Name
-
Rv1189
- Product
-
Possible alternative RNA polymerase sigma factor SigI
- Functional Category
-
Information pathways
- Location
- 1332092..1332964 (+ strand)
- Gene Length
- 872 bp
- Nucleotides
-
TGTCGCAACACGACCCGGTAAGTGCGGCCTGGCGGGCGCATCGGGCCTACCTGGTGGACCTCGCGTTTCGTATGGTAGGTGACATCGGCGTGGCCGAAGACATGGTGCAAGAGGCATTTTCCCGCTTGCTGCGGGCTCCGGTCGGCGACATCGACGACGAGCGTGGCTGGCTGATCGTGGTCACCAGCCGGCTGTGCCTGGATCACATCAAGTCGGCGTCGACACGCCGGGAGCGCCCGCAGGACATCGCCGCATGGCACGACGGTGACGCCAGCGTGTCATCGGTTGACCCGGCTGACCGGGTGACTCTCGACGACGAGGTCCGGCTGGCTTTGCTGATCATGCTCGAGCGCCTCGGCCCCGCGGAGCGGGTGGTGTTCGTGCTGCACGAGATCTTTGGGCTGCCCTACCAGCAAATCGCCACGACGATTGGCAGCCAGGCCTCCACATGCCGGCAGCTGGCTCATCGGGCCCGTCGCAAGATCAACGAATCGCGCATTGCGGCCAGCGTGGAGCCAGCCCAGCATCGCGTCGTCACCAGAGCTTTCATCGAAGCCTGCTCCAACGGAGACCTGGACACCCTGCTCGAGGTGCTGGATCCGGGTGTCGCCGGCGAGATCGACGCCCGCAAAGGCGTTGTCGTCGTGGGCGCGGATCGGGTTGGCCCGACCATCCTGCGCCACTGGAGTCACCCCGCCACCGTCCTGGTAGCCCAGCCGGTGTGCGGTCAACCGGCGGTGCTGGCCTTTGTCAACCGAGCGCTTGCCGGCGTGTTGGCCCTGTCGATCGAGGCCGGCAAGATCACAAAAATCCATGTCTTAGTGCAGCCTTCAACATTGGACCCGTTACGGGCCGAACTCGGCGGCGGTTAG
- Drug Resistance
- Mutations
- Function
- Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). {ECO:0000250}.
- Family
-
Sigma-70 factor family, ECF subfamily
- GO
-
- DNA-binding transcription factor activity GO:0003700 molecular_function
- DNA binding GO:0003677 molecular_function
- DNA-templated transcription, initiation GO:0006352 biological_process
- sigma factor activity GO:0016987 molecular_function
- InterPro
Summary
- Name
- Probable ECF RNA polymerase sigma factor SigI (ECF sigma factor SigI) (Alternative RNA polymerase sigma factor SigI) (RNA polymerase sigma-I factor) (Sigma-I factor)
- Family
- Sigma-70 factor family, ECF subfamily
- Protein Sequence
-
MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSRLLRAPVGDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDGDASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQHRVVTRAFIEACSNGDLDTLLEVLDPGVAGEIDARKGVVVVGADRVGPTILRHWSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPSTLDPLRAELGGG
- Mass
- 31,431 Da
- Length
- 290 Aa
Rv1189 doesn't seem to be a targeted by any drug.
Rv1189 doesn't seem to be involved in any pathway.
- Cascade of extracytoplasmic function sigma factors in Mycobacterium tuberculosis: identification of a sigmaJ-dependent promoter upstream of sigI.
- FEMS Microbiol Lett. 2008 Mar;280(1):120-6. doi: 10.1111/j.1574-6968.2007.01054.x. Epub 2008 Jan 31.
- Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis.
- Mol Microbiol. 1999 Jan;31(2):715-24.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.