Function

May play a pivotal role in the interaction between M.tuberculosis and host. Can enhance the survival within macrophages under stress conditions such as H(2)O(2), SDS and low pH. Increases the production of IL-6 and IL-1beta from macrophages, and decreases the secretion of suppressor of cytokine signaling 3 (SOCS-3). These changes probably involve the p38-ERK-NF-kappa-B signaling pathway. Also precipitates the macrophage death. {ECO:0000269|PubMed:27147522}.

Family

Mycobacterial PE family

GO

• pathogenesis GO:0009405 biological_process
• cell wall GO:0005618 cellular_component
• extracellular region GO:0005576 cellular_component

InterPro

• IPR000084

UniProt

Q79FR3

GenBank

Rv1195

EnsemblBacteria

Rv1195

Mycobrowser

Rv1195

Rv1195 doesn't seem to be a targeted by any drug.

Rv1195 doesn't seem to be involved in any pathway.