Function

Could be a crucial virulence factor for intracellular survival of M.tuberculosis (PubMed:23300718). Favors development of Th2-type response, and downregulates the proinflammatory and Th1-type response (PubMed:19880448, PubMed:21451109). Specifically interacts with the human Toll-like receptor 2 (TLR2), leading to an early and sustained activation of p38 MAPK, which induces IL-10 production and activates Th2-type immune response (PubMed:19880448). Also inhibits proinflammatory cytokines IL-12p40 and TNF-alpha production. Acts by upregulating the expression as well as tyrosine phosphorylation of suppressor of cytokine signaling 3 (SOCS-3), leading to the inhibition of phosphorylation of I-kappa-B-alpha, thereby preventing nuclear translocation of the NF-kappa-B/REL subunits and expression of NF-kappa-B regulated genes like IL-12 and TNF-alpha. Induction of SOCS-3 probably depends on the activation of p38 MAPK (PubMed:21451109). {ECO:0000269|PubMed:19880448, ECO:0000269|PubMed:21451109, ECO:0000269|PubMed:23300718}.

Family

Mycobacterial PPE family

GO

• cell surface GO:0009986 cellular_component
• pathogenesis GO:0009405 biological_process
• cell wall GO:0005618 cellular_component
• extracellular region GO:0005576 cellular_component

InterPro

• IPR022171
• IPR000030
• IPR038332

UniProt

L7N675

GenBank

Rv1196

EnsemblBacteria

Rv1196

Mycobrowser

Rv1196

Rv1196 doesn't seem to be a targeted by any drug.

Rv1196 doesn't seem to be involved in any pathway.