Gene - combatTB X

glgC

Type: protein_coding
Name: glgC
Locus Name: Rv1213
Product: Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase)
Functional Category: Intermediary metabolism and respiration
Location: 1355836..1357050 (+ strand)
Gene Length: 1214 bp
Nucleotides: TGAGAGAAGTGCCGCACGTGCTGGGCATAGTCTTAGCCGGCGGTGAGGGCAAGCGGCTTTATCCGCTGACCGCGGACCGGGCCAAGCCCGCGGTTCCTTTCGGCGGCGCCTATCGATTGATCGATTTCGTACTCTCAAACCTCGTCAACGCCCGGTATCTGAGGATCTGTGTTCTCACCCAATACAAGTCGCATTCACTGGACCGCCATATCTCGCAGAACTGGCGGTTGTCTGGTCTGGCGGGTGAGTACATCACCCCGGTGCCGGCACAGCAGCGCCTCGGCCCGCGCTGGTATACCGGCTCCGCCGATGCGATCTATCAATCGCTGAACTTGATCTACGACGAAGATCCAGACTACATAGTGGTTTTCGGCGCCGACCACGTCTACCGTATGGATCCCGAACAGATGGTCCGGTTCCACATCGACAGCGGTGCCGGCGCGACGGTGGCCGGCATACGGGTTCCACGTGAAAATGCGACCGCGTTCGGTTGTATCGACGCCGATGACTCCGGCCGTATTCGCAGCTTCGTTGAGAAGCCGCTGGAGCCGCCCGGAACCCCCGACGACCCCGACACCACGTTCGTCTCAATGGGCAACTACATTTTCACGACCAAGGTGCTTATCGACGCGATTCGCGCCGACGCCGACGACGACCACTCGGACCACGACATGGGTGGTGACATCGTTCCGCGGTTGGTGGCCGACGGTATGGCGGCGGTCTATGACTTCTCCGATAACGAAGTGCCTGGTGCCACCGATCGCGACCGAGCATATTGGCGCGACGTCGGGACGCTTGACGCGTTTTACGACGCACATATGGACCTGGTGTCGGTGCACCCGGTGTTCAACCTGTACAACAAGCGGTGGCCGATCCGCGGGGAGTCGGAGAACCTGGCGCCGGCGAAGTTCGTCAATGGCGGCTCCGCACAGGAGTCGGTGGTTGGTGCCGGCAGCATCATCTCGGCGGCCTCGGTGCGTAATTCGGTGCTGTCGTCGAACGTCGTGGTCGACGACGGCGCGATCGTTGAGGGCAGTGTGATCATGCCCGGCACCCGCGTTGGGCGCGGGGCGGTGGTGCGCCACGCGATCCTGGACAAGAACGTCGTCGTCGGGCCCGGTGAGATGGTCGGCGTGGATCTGGAGAAGGACCGGGAACGCTTCGCGATCAGCGCCGGCGGCGTGGTCGCCGTGGGCAAGGGTGTTTGGATCTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in the biosynthesis of ADP-glucose building block required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. {ECO:0000269|PubMed:18808383, ECO:0000269|PubMed:27513637}.

Family

Bacterial/plant glucose-1-phosphate adenylyltransferase family

GO

capsule polysaccharide biosynthetic process GO:0045227 biological_process
glucose-1-phosphate adenylyltransferase activity GO:0008878 molecular_function
cytosol GO:0005829 cellular_component
ATP binding GO:0005524 molecular_function
glycogen biosynthetic process GO:0005978 biological_process
glucan biosynthetic process GO:0009250 biological_process

InterPro

UniProt: P9WN43
GenBank: Rv1213
EnsemblBacteria: Rv1213
Mycobrowser: Rv1213

Summary

Name: Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase)
Family: Bacterial/plant glucose-1-phosphate adenylyltransferase family
Protein Sequence: MREVPHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFVLSNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGSADAIYQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVRFHIDSGAGATVAGIRVPRENATAFGCIDADDSGRIRSFVEKPLEPPGTPDDPDTTFVSMGNYIFTTKVLIDAIRADADDDHSDHDMGGDIVPRLVADGMAAVYDFSDNEVPGATDRDRAYWRDVGTLDAFYDAHMDLVSVHPVFNLYNKRWPIRGESENLAPAKFVNGGSAQESVVGAGSIISAASVRNSVLSSNVVVDDGAIVEGSVIMPGTRVGRGAVVRHAILDKNVVVGPGEMVGVDLEKDRERFAISAGGVVAVGKGVWI
Mass: 43,800 Da
Length: 404 Aa

Rv1213 doesn't seem to be a targeted by any drug.

Amino sugar and nucleotide sugar metabolism mtu00520
mtu00520
PATHWAY_MAP mtu00520 Amino sugar and nucleotide sugar metabolism

Starch and sucrose metabolism mtu00500
mtu00500
PATHWAY_MAP mtu00500 Starch and sucrose metabolism

Metabolic Network for the Biosynthesis of Intra- and Extracellular alpha-Glucans Required for Virulence of Mycobacterium tuberculosis.: PLoS Pathog. 2016 Aug 11;12(8):e1005768. doi: 10.1371/journal.ppat.1005768. eCollection 2016 Aug.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice.: Mol Microbiol. 2008 Nov;70(3):762-74. doi: 10.1111/j.1365-2958.2008.06445.x. Epub 2008 Sep 18.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.