Gene - combatTB X

Rv1219c

Type: protein_coding
Name: Rv1219c
Locus Name: Rv1219c
Product: Probable transcriptional regulatory protein
Functional Category: Regulatory proteins
Location: 1362723..1363361 (- strand)
Gene Length: 638 bp
Nucleotides: ATGCGTTCAGCCGATCTGACCGCGCACGCCAGGATCAGAGAGGCGGCCATCGAACAGTTCGGTCGGCACGGATTCGGTGTCGGGCTGCGAGCCATCGCCGAAGCGGCGGGGGTGAGCGCGGCATTGGTCATCCACCATTTCGGTTCCAAGGAAGGTCTGCGCAAGGCCTGCGACGACTTCGTCGCCGAAGAGATCCGCAGCAGCAAGGCTGCGGCACTGAAGTCCAACGACCCGACCACCTGGCTCGCGCAGATGGCCGAGATCGAATCCTACGCACCGCTGATGGCATACCTGGTGCGCAGCATGCAATCCGGCGGCGAGCTGGCGAAGATGCTGTGGCAGAAGATGATCGACAACGCCGAGGAGTACCTGGACGAAGGAGTACGCGCCGGTACGGTCAAGCCCAGCCGCGACCCGCGCGCCCGTGCTCGGTTTCTGGCGATCACCGGAGGCGGAGGCTTCCTGCTTTATCTGCAAATGCACGAAAACCCAACCGATCTCCGTGCAGCGTTACGCGACTACGCGCACGACATGGTGCTGCCTTCCCTGGAGGTCTACACCGAAGGCCTGCTGGCCGACCGCGCCATGTACGAGGCCTTCCTGGCCGAAGCTCAACAAGGAGAAGCACATGTCGGCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene (PubMed:24424575). Important for survival in prolonged stationary phase and during macrophage infection (PubMed:24590482). May be used to eliminate non-growing mycobacteria (PubMed:25012658). {ECO:0000269|PubMed:24424575, ECO:0000269|PubMed:24590482, ECO:0000269|PubMed:25012658}.

Family

Unknown

GO

DNA binding GO:0003677 molecular_function

InterPro

UniProt: O86312
GenBank: Rv1219c
EnsemblBacteria: Rv1219c
Mycobrowser: Rv1219c

Summary

Name: HTH-type transcriptional regulatory protein RaaS (Regulator of antimicrobial-assisted survival)
Family: Unknown
Protein Sequence: MRSADLTAHARIREAAIEQFGRHGFGVGLRAIAEAAGVSAALVIHHFGSKEGLRKACDDFVAEEIRSSKAAALKSNDPTTWLAQMAEIESYAPLMAYLVRSMQSGGELAKMLWQKMIDNAEEYLDEGVRAGTVKPSRDPRARARFLAITGGGGFLLYLQMHENPTDLRAALRDYAHDMVLPSLEVYTEGLLADRAMYEAFLAEAQQGEAHVG
Mass: 23,181 Da
Length: 212 Aa

Rv1219c doesn't seem to be a targeted by any drug.

Rv1219c doesn't seem to be involved in any pathway.

Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis.: Protein Sci. 2014 Apr;23(4):423-32. doi: 10.1002/pro.2424. Epub 2014 Mar 10.
Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.: J Biol Chem. 2014 Sep 5;289(36):25241-9. doi: 10.1074/jbc.M114.577338. Epub 2014 Jul 10.
Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions.: Antimicrob Agents Chemother. 2014 May;58(5):2798-806. doi: 10.1128/AAC.02774-13. Epub 2014 Mar 3.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.