htrA
- Type
- protein_coding
- Name
- htrA
- Locus Name
-
Rv1223
- Product
-
Probable serine protease HtrA (DEGP protein)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1365875..1367461 (+ strand)
- Gene Length
- 1586 bp
- Nucleotides
-
TGGATACTAGGGTGGACACGGACAACGCGATGCCTGCACGTTTTAGCGCCCAGATTCAGAATGAGGATGAGGTGACCTCCGACCAAGGCAACAACGGCGGCCCGAACGGCGGAGGCCGCCTGGCGCCGCGCCCGGTTTTTCGGCCACCGGTCGACCCGGCGTCGCGTCAAGCGTTCGGGCGTCCGTCCGGGGTCCAAGGGTCCTTTGTGGCCGAGCGTGTGCGCCCGCAGAAGTACCAGGACCAGTCTGACTTCACACCGAACGATCAGCTTGCTGACCCGGTGCTTCAGGAGGCGTTCGGTCGTCCGTTCGCGGGCGCCGAATCGCTGCAGCGCCATCCCATCGATGCCGGAGCGCTGGCAGCTGAGAAAGACGGTGCCGGCCCCGACGAGCCCGACGATCCGTGGCGCGACCCCGCGGCCGCGGCCGCGCTGGGGACGCCAGCGCTAGCCGCGCCGGCACCGCACGGTGCGCTGGCCGGCAGCGGCAAGCTGGGTGTGCGCGACGTGCTGTTTGGCGGCAAGGTGTCCTACTTGGCGCTGGGCATCTTGGTCGCTATCGCACTGGTGATCGGCGGCATCGGCGGTGTCATCGGCCGCAAGACCGCGGAAGTAGTCGATGCGTTCACCACGTCGAAGGTGACCCTGTCGACCACTGGCAATGCCCAGGAACCGGCCGGCCGGTTCACCAAGGTGGCGGCCGCCGTGGCCGATTCGGTGGTGACCATTGAGTCGGTCAGCGACCAGGAGGGCATGCAAGGTTCCGGCGTCATCGTCGATGGCCGCGGCTACATCGTCACCAACAATCACGTGATCTCTGAGGCGGCCAACAATCCCAGCCAGTTCAAGACGACCGTGGTGTTCAACGACGGCAAGGAGGTGCCCGCCAATCTGGTGGGTCGTGACCCCAAGACCGACTTGGCCGTCCTCAAGGTCGACAACGTCGACAATCTGACCGTGGCCCGGCTCGGTGATTCCAGCAAGGTACGGGTCGGTGACGAAGTCCTCGCGGTCGGCGCGCCCCTGGGGCTGCGCAGTACGGTGACCCAGGGCATTGTCAGCGCGCTACACCGCCCCGTTCCGTTGTCGGGCGAGGGCTCTGACACCGACACCGTCATTGACGCAATTCAGACCGACGCCTCGATCAACCACGGTAACTCCGGCGGTCCGCTAATCGACATGGATGCCCAGGTGATTGGCATCAACACCGCCGGTAAGTCACTGTCGGATAGCGCCAGCGGGCTGGGCTTTGCGATCCCGGTCAACGAGATGAAATTGGTGGCAAATTCTCTGATCAAAGACGGAAAGATCGTGCATCCGACGTTGGGCATCAGCACCCGGTCAGTAAGCAACGCGATCGCGTCGGGCGCGCAGGTGGCCAATGTAAAGGCGGGAAGTCCCGCGCAGAAGGGCGGGATCTTGGAGAACGATGTGATCGTCAAGGTCGGTAACCGCGCGGTCGCCGACTCCGACGAGTTCGTCGTCGCCGTGCGCCAGTTGGCTATCGGCCAGGACGCTCCGATAGAGGTGGTCCGCGAGGGTCGGCATGTGACGCTGACGGTGAAACCGGACCCCGATAGCACCTAG
- Drug Resistance
- Mutations
- Function
- Unknown
- Family
-
Unknown
- GO
-
- cell wall GO:0005618 cellular_component
- integral component of plasma membrane GO:0005887 cellular_component
- plasma membrane GO:0005886 cellular_component
- serine-type endopeptidase activity GO:0004252 molecular_function
- InterPro
5ZVJ
- Name
- Probable serine protease HtrA (DEGP protein)
- Family
- Unknown
- Protein Sequence
-
MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSVVTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIGINTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST
- Mass
- 54,190 Da
- Length
- 528 Aa
Summary
Rv1223 doesn't seem to be a targeted by any drug.
Rv1223 doesn't seem to be involved in any pathway.
- The crystal structure of Mycobacterium tuberculosis high-temperature requirement A protein reveals an autoregulatory mechanism.
- Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):803-809. doi: 10.1107/S2053230X18016217. Epub 2018 Nov 29.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.