sugA
- Type
- protein_coding
- Name
- sugA
- Locus Name
-
Rv1236
- Product
-
Probable sugar-transport integral membrane protein ABC transporter SugA
- Functional Category
-
Cell wall and cell processes
- Location
- 1378927..1379850 (+ strand)
- Gene Length
- 923 bp
- Nucleotides
-
TGACCTCCGTTGAACAGCGGACCGCCACCGCGGTCTTTTCCCGTACCGGGAGCCGCATGGCCGAACGGCGACTGGCGTTCATGCTGGTCGCACCCGCCGCGATGTTGATGGTGGCGGTGACGGCCTATCCCATCGGTTACGCGCTGTGGCTTAGCCTGCAGCGCAACAACCTGGCCACCCCGAACGACACCGCGTTCATCGGGCTGGGCAACTATCACACGATCCTGATCGACCGGTATTGGTGGACGGCGCTGGCGGTGACGCTGGCGATCACGGCGGTTTCGGTGACGATCGAATTCGTCTTGGGGTTAGCGCTCGCCCTGGTAATGCACCGCACGCTGATCGGCAAGGGGTTGGTGCGCACCGCGGTGCTCATTCCGTACGGCATCGTCACGGTGGTCGCCTCGTATAGCTGGTACTACGCCTGGACGCCGGGCACCGGGTATCTGGCCAACCTGCTGCCGTATGACAGTGCGCCACTGACGCAACAGATCCCGTCGTTGGGCATCGTGGTGATCGCCGAGGTCTGGAAGACGACGCCGTTTATGTCGCTGCTGCTTTTGGCCGGGTTGGCGCTGGTCCCCGAGGATCTGCTAAGAGCAGCGCAGGTTGACGGCGCCAGCGCCTGGCGGCGGTTGACGAAGGTCATCTTGCCGATGATCAAGCCGGCGATCGTGGTTGCTCTGCTCTTCAGGACCCTGGACGCTTTCCGGATTTTCGACAACATCTATGTGCTGACCGGCGGCAGCAACAACACCGGATCGGTGTCGATCTTGGGCTACGACAACCTGTTCAAGGGGTTCAACGTGGGCCTTGGTTCGGCGATCAGCGTGCTGATCTTTGGCTGCGTGGCCGTCATTGCGTTCATTTTCATCAAGTTGTTCGGCGCCGCGGCGCCCGGGGGTGAGCCAAGTGGGCGTTGA
- Drug Resistance
- Mutations
- Function
- Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:21118978}.
- Family
-
Binding-protein-dependent transport system permease family
- GO
-
- growth of symbiont in host GO:0044117 biological_process
- transmembrane transport GO:0055085 biological_process
- carbohydrate transport GO:0008643 biological_process
- plasma membrane GO:0005886 cellular_component
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Trehalose transport system permease protein SugA
- Family
- Binding-protein-dependent transport system permease family
- Protein Sequence
-
MTSVEQRTATAVFSRTGSRMAERRLAFMLVAPAAMLMVAVTAYPIGYALWLSLQRNNLATPNDTAFIGLGNYHTILIDRYWWTALAVTLAITAVSVTIEFVLGLALALVMHRTLIGKGLVRTAVLIPYGIVTVVASYSWYYAWTPGTGYLANLLPYDSAPLTQQIPSLGIVVIAEVWKTTPFMSLLLLAGLALVPEDLLRAAQVDGASAWRRLTKVILPMIKPAIVVALLFRTLDAFRIFDNIYVLTGGSNNTGSVSILGYDNLFKGFNVGLGSAISVLIFGCVAVIAFIFIKLFGAAAPGGEPSGR
- Mass
- 33,051 Da
- Length
- 307 Aa
Rv1236 doesn't seem to be a targeted by any drug.
Rv1236 doesn't seem to be involved in any pathway.
- Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.
- Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21761-6. doi: 10.1073/pnas.1014642108. Epub 2010 Nov 30.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.