sugC
- Type
- protein_coding
- Name
- sugC
- Locus Name
-
Rv1238
- Product
-
Probable sugar-transport ATP-binding protein ABC transporter SugC
- Functional Category
-
Cell wall and cell processes
- Location
- 1380684..1381865 (+ strand)
- Gene Length
- 1181 bp
- Nucleotides
-
TGGCCGAGATTGTGTTGGACCACGTCAACAAGAGTTACCCCGACGGTCACACAGCGGTGCGCGACCTCAACCTCACCATCGCCGACGGCGAATTTCTGATCCTGGTAGGGCCTTCCGGTTGTGGCAAGACCACGACGCTGAATATGATTGCTGGGCTTGAAGATATCTCGTCGGGAGAACTGCGCATCGCCGGTGAGCGGGTAAACGAGAAGGCGCCAAAGGACCGTGACATCGCGATGGTGTTCCAGTCGTACGCGCTTTACCCGCATATGACGGTGCGCCAGAACATCGCGTTCCCGCTGACCCTGGCGAAGATGAGAAAGGCCGACATCGCGCAGAAGGTCTCCGAGACTGCAAAAATCCTTGACCTGACCAACCTTCTGGATCGCAAGCCCTCACAATTGTCGGGTGGTCAGCGACAGCGGGTCGCGATGGGCAGGGCAATCGTGCGCCATCCCAAAGCATTCCTGATGGACGAGCCGCTGTCGAACTTGGACGCGAAGTTGCGGGTCCAGATGCGCGGCGAGATTGCCCAGCTGCAGCGGAGGCTGGGTACCACCACCGTCTACGTCACCCACGACCAGACCGAGGCAATGACGCTGGGCGATCGCGTGGTAGTGATGTACGGGGGCATCGCACAGCAGATCGGCACCCCTGAGGAGCTTTACGAACGGCCCGCCAATCTGTTTGTCGCGGGCTTTATCGGCTCGCCGGCCATGAATTTCTTCCCTGCCAGGCTGACCGCGATCGGACTGACCCTGCCGTTCGGTGAGGTGACGCTGGCCCCCGAAGTCCAGGGGGTGATCGCAGCGCACCCGAAACCGGAAAACGTCATCGTAGGCGTGCGGCCGGAGCATATCCAGGACGCAGCATTGATCGACGCGTATCAACGCATCAGGGCGCTGACCTTCCAGGTGAAGGTCAACTTGGTCGAGTCTTTAGGCGCCGACAAATATCTGTATTTCACTACCGAGAGCCCGGCTGTGCACTCGGTTCAGTTGGACGAGTTGGCGGAGGTAGAGGGGGAGTCGGCGTTACACGAAAATCAGTTCGTGGCAAGGGTTCCCGCCGAGTCCAAGGTAGCCATCGGGCAGTCGGTCGAGTTGGCTTTCGATACCGCCAGACTTGCCGTCTTCGACGCCGACTCCGGTGCGAACCTGACCATTCCGCACCGCGCCTAA
- Drug Resistance
- Mutations
- Function
- Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for energy coupling to the transport system. {ECO:0000269|PubMed:21118978}.
- Family
-
ABC transporter superfamily
- GO
-
- growth of symbiont in host GO:0044117 biological_process
- pathogenesis GO:0009405 biological_process
- trehalose transport GO:0015771 biological_process
- ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing GO:0055052 cellular_component
- ATP binding GO:0005524 molecular_function
- ATPase activity GO:0016887 molecular_function
- InterPro
Summary
- Name
- Trehalose import ATP-binding protein SugC (EC 3.6.3.-)
- Family
- ABC transporter superfamily
- Protein Sequence
-
MAEIVLDHVNKSYPDGHTAVRDLNLTIADGEFLILVGPSGCGKTTTLNMIAGLEDISSGELRIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLTLAKMRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQRVAMGRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIAQLQRRLGTTTVYVTHDQTEAMTLGDRVVVMYGGIAQQIGTPEELYERPANLFVAGFIGSPAMNFFPARLTAIGLTLPFGEVTLAPEVQGVIAAHPKPENVIVGVRPEHIQDAALIDAYQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQLDELAEVEGESALHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTIPHRA
- Mass
- 42,915 Da
- Length
- 393 Aa
Rv1238 doesn't seem to be a targeted by any drug.
-
-
ABC transporters mtu02010
mtu02010Environmental Information Processing; Membrane transport
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.
- Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21761-6. doi: 10.1073/pnas.1014642108. Epub 2010 Nov 30.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.