deaD
- Type
- protein_coding
- Name
- deaD
- Locus Name
-
Rv1253
- Product
-
Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)
- Functional Category
-
Information pathways
- Location
- 1399970..1401661 (+ strand)
- Gene Length
- 1691 bp
- Nucleotides
-
TGGCCTTCCCGGAATATTCGCCTGCGGCGTCCGCTGCGACGTTTGCTGACCTGCAGATTCATCCCCGCGTCTTGCGGGCGATCGGCGACGTCGGTTACGAGTCACCGACGGCTATCCAGGCGGCTACGATCCCGGCGTTGATGGCAGGCTCCGACGTGGTGGGGCTGGCGCAGACCGGCACCGGCAAGACGGCGGCATTTGCGATTCCGATGCTGTCCAAGATCGACATCACCAGCAAGGTGCCCCAGGCGCTGGTGCTGGTGCCCACCCGGGAGCTGGCTCTGCAGGTGGCCGAGGCGTTCGGCCGCTACGGTGCCTATCTGTCGCAACTCAACGTGCTGCCGATCTACGGCGGATCGTCGTATGCCGTGCAACTGGCCGGATTGAGACGCGGCGCGCAGGTGGTGGTTGGCACCCCCGGTCGTATGATAGACCATCTCGAACGGGCGACCTTGGACCTGTCGCGGGTGGACTTTCTAGTGCTCGATGAGGCCGATGAGATGCTGACCATGGGTTTCGCCGACGACGTTGAGCGCATTCTGTCCGAGACCCCCGAATACAAGCAGGTCGCCCTGTTTTCCGCGACCATGCCGCCGGCGATCCGCAAACTCAGCGCCAAGTATCTGCACGATCCGTTCGAAGTCACTTGTAAGGCGAAAACCGCTGTGGCCGAGAATATTTCGCAGAGCTACATTCAGGTAGCACGGAAGATGGACGCGCTCACCAGAGTGCTCGAAGTCGAGCCGTTCGAGGCGATGATCGTCTTTGTCCGCACCAAGCAGGCGACCGAGGAGATTGCCGAAAAGCTGCGTGCCCGAGGGTTTTCCGCGGCTGCCATCAGCGGTGACGTCCCGCAGGCGCAGCGGGAGCGGACCATCACGGCGCTGCGGGACGGCGACATCGATATCCTGGTCGCCACCGATGTGGCGGCGCGCGGACTCGACGTGGAGCGGATATCACACGTGCTTAACTACGACATCCCGCACGACACCGAGTCCTACGTACACCGGATCGGGCGCACCGGCAGGGCCGGGCGTTCGGGAGCCGCGCTGATATTCGTCTCGCCACGGGAGCTTCACCTGCTCAAGGCGATCGAAAAGGCTACGCGGCAAACGCTTACCGAGGCGCAATTGCCCACCGTCGAGGATGTCAACACCCAGCGGGTGGCCAAGTTCGCCGATTCCATCACCAATGCGCTGGGCGGTCCGGGAATCGAGCTGTTCCGCCGACTGGTCGAGGAGTATGAACGCGAGCATGATGTCCCGATGGCTGACATCGCCGCGGCACTGGCCGTGCAGTGCCGCGGCGGTGAGGCATTCCTGATGGCACCCGACCCGCCGCTTTCGCGGCGCAACCGCGACCAGCGTCGGGACCGTCCGCAAAGGCCCAAGCGTAGACCGGACTTGACCACCTACCGCGTCGCCGTCGGCAAGCGGCACAAGATCGGTCCAGGCGCCATCGTCGGCGCCATCGCCAATGAGGGTGGGCTGCACCGCAGCGACTTCGGTCAGATCCGTATCGGGCCAGACTTCTCGCTAGTAGAATTGCCGGCGAAGCTGCCCCGCGCGACGCTCAAAAAGCTTGCACAGACCCGTATCTCGGGTGTGCTGATCGACCTTCGGCCATACCGGCCGCCCGACGCGGCGCGCCGGCATAATGGCGGCAAACCACGGCGGAAACACGTCGGATGA
- Drug Resistance
- Mutations
- Function
- DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. {ECO:0000255|HAMAP-Rule:MF_00964}.
- Family
-
DEAD box helicase family, DeaD subfamily
- GO
-
- RNA helicase activity GO:0003724 molecular_function
- RNA binding GO:0003723 molecular_function
- cell wall GO:0005618 cellular_component
- ATP binding GO:0005524 molecular_function
- cytosol GO:0005829 cellular_component
- cellular response to cold GO:0070417 biological_process
- ribosomal large subunit assembly GO:0000027 biological_process
- RNA catabolic process GO:0006401 biological_process
- InterPro
Summary
- Name
- ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A)
- Family
- DEAD box helicase family, DeaD subfamily
- Protein Sequence
-
MAFPEYSPAASAATFADLQIHPRVLRAIGDVGYESPTAIQAATIPALMAGSDVVGLAQTGTGKTAAFAIPMLSKIDITSKVPQALVLVPTRELALQVAEAFGRYGAYLSQLNVLPIYGGSSYAVQLAGLRRGAQVVVGTPGRMIDHLERATLDLSRVDFLVLDEADEMLTMGFADDVERILSETPEYKQVALFSATMPPAIRKLSAKYLHDPFEVTCKAKTAVAENISQSYIQVARKMDALTRVLEVEPFEAMIVFVRTKQATEEIAEKLRARGFSAAAISGDVPQAQRERTITALRDGDIDILVATDVAARGLDVERISHVLNYDIPHDTESYVHRIGRTGRAGRSGAALIFVSPRELHLLKAIEKATRQTLTEAQLPTVEDVNTQRVAKFADSITNALGGPGIELFRRLVEEYEREHDVPMADIAAALAVQCRGGEAFLMAPDPPLSRRNRDQRRDRPQRPKRRPDLTTYRVAVGKRHKIGPGAIVGAIANEGGLHRSDFGQIRIGPDFSLVELPAKLPRATLKKLAQTRISGVLIDLRPYRPPDAARRHNGGKPRRKHVG
- Mass
- 61,453 Da
- Length
- 563 Aa
Rv1253 doesn't seem to be a targeted by any drug.
-
-
RNA degradation mtu03018
mtu03018Genetic Information Processing; Folding, sorting and degradation
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.