Rv1272c
- Type
- protein_coding
- Name
- Rv1272c
- Locus Name
-
Rv1272c
- Product
-
Probable drugs-transport transmembrane ATP-binding protein ABC transporter
- Functional Category
-
Cell wall and cell processes
- Location
- 1420410..1422305 (- strand)
- Gene Length
- 1895 bp
- Nucleotides
-
GTGACCGCGCCACCGGGCGCACGCCCCCGTGCCGCAAGCCCGCCCCCGAACATGCGGTCCCGCGACTTCTGGGGATCGGCAGCCCGACTGGTGAAACGGCTGGCGCCACAACGCCGGCTGAGCATCGCGGTGATCACACTGGGAATCGCCGGCACGACGATCGGCGTCATCGTTCCACGGATCCTCGGCCATGCCACCGATTTGCTGTTCAACGGCGTGATCGGGCGAGGGCTACCGGGGGGAATCACCAAGGCACAGGCCGTCGCTTCGGCTCGGGCCCGTGGTGACAACACCTTCGCCGACCTGCTGTCCGGGATGAACGTGGTGCCGGGCCAAGGTGTGGACTTCGCCGCGGTGGAGCGAACACTGGCGCTGGCGTTGGCGCTGTATCTGGCTGCAGCGCTGATGATTTGGGCACAAGCCCGGCTGCTCAACCTCACCGTGCAGAAAACGATGGTCAGGTTGCGGACCGATGTCGAAGACAAGGTGCACCGGCTGCCGCTGTCCTACTTCGACGGACAACAGCGCGGTGAGCTGCTGAGCCGGGTCACCAATGACATCGACAACCTCCAGTCGTCGCTGTCAATGACGATCAGCCAGCTGGTGACGTCGATTCTGACCATGGTGGCGGTGCTGGCCATGATGGTGTCGATCTCGGGCCTGCTGGCGCTGATCACACTGCTGACGGTGCCGCTGTCGCTGCTGGTGACACGCGCGATCACCCGGCGGTCACAGCCCCTATTCGTAGCTCACTGGACCAGCACCGGGCGCCTCAACGCCCATCTCGAAGAGACCTACAGCGGGTTCACGGTAGTCAAGACGTTCGGCCACCAAGCGGCCGCACGAGAACGGTTCCACGAGTTGAATGACGACGTCTACCAGGCCGGTTTCGGCGCCCAGTTCCTCTCTGGTCTCGTGCAGCCGGCGACGGCGTTCATCGGCAACCTCGGCTACGTCGCGGTCGCGGTGGCCGGTGGCCTGCAGGTAGCCACCGGGCAGATCACGCTCGGCAGCATCCAGGCGTTCATCCAGTACATCCGCCAGTTCAACATGCCGCTGAGCCAGCTGGCCGGGATGTACAACGCCCTGCAGTCCGGGGTGGCCAGCGCGGAGCGGGTGTTCGACGTGCTCGACGAGCCCGAGGAGTCGCCGGAGCCTGAGCCGGAGCTGCCGAACCTAACCGGACGGGTCGAGTTTGAGCACGTGAACTTTGCTTACCTCCCGGGCACGCCGGTGATCCGCGACCTGTCGCTGGTGGCCGAACCGGGTAGCACGGTGGCGATCGTCGGACCGACGGGAGCCGGCAAGACCACGCTGGTGAACCTGCTAATGCGGTTCTACGAGATCGGTTCCGGACGAATCCTGATCGACGGGGTGGATATCGCCTCGGTAAGCCGGCAGTCGCTGCGATCGCGAATCGGCATGGTGTTGCAAGACACCTGGCTCTACGACGGGACCATCGCGGAGAACATCGCCTACGGACGGCCGGAGGCCACCACAGACGAGATAGTAGAAGCCGCCAGGGCGGCCCATGTCGACCGGTTTGTGAACACACTGCCTGCTGGCTACCAGACACGGGTCAGCGGCGACGGCGGCAGCATCAGCGTCGGCGAGAAGCAACTCATTACCATCGCCCGCGCCTTTCTTGCCCGCCCGCAGCTGTTGATCCTGGACGAGGCGACCAGCTCGGTCGATACCCGCACCGAGCTGCTCATCCAGCGAGCGATGCGCGAGCTTCGCCGGGATCGTACGAGTTTCATTATCGCCCACCGACTTTCGACGATTCGCGATGCCGACCACATCCTGGTGGTCCAGACCGGCCAGATCGTCGAACGCGGCAACCACGCCGAGCTGTTGGCCCGGCGCGGGGTCTATTACCAGATGACGCGGGCCTA
- Drug Resistance
- Mutations
- Function
- ABC transporter involved in fatty acid import (PubMed:29360453). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable). {ECO:0000269|PubMed:29360453, ECO:0000305|PubMed:29360453}.
- Family
-
ABC transporter superfamily, Lipid exporter (TC 3.A.1.106) family
- GO
-
- ATP binding GO:0005524 molecular_function
- ATPase-coupled transmembrane transporter activity GO:0042626 molecular_function
- plasma membrane GO:0005886 cellular_component
- integral component of membrane GO:0016021 cellular_component
- InterPro
Summary
- Name
- Fatty acid ABC transporter ATP-binding/permease protein (EC 7.6.2.-)
- Family
- ABC transporter superfamily, Lipid exporter (TC 3.A.1.106) family
- Protein Sequence
-
MTAPPGARPRAASPPPNMRSRDFWGSAARLVKRLAPQRRLSIAVITLGIAGTTIGVIVPRILGHATDLLFNGVIGRGLPGGITKAQAVASARARGDNTFADLLSGMNVVPGQGVDFAAVERTLALALALYLAAALMIWAQARLLNLTVQKTMVRLRTDVEDKVHRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTISQLVTSILTMVAVLAMMVSISGLLALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLNAHLEETYSGFTVVKTFGHQAAARERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYVAVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDEPEESPEPEPELPNLTGRVEFEHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTGAGKTTLVNLLMRFYEIGSGRILIDGVDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGRPEATTDEIVEAARAAHVDRFVNTLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLLILDEATSSVDTRTELLIQRAMRELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNHAELLARRGVYYQMTRA
- Mass
- 68,305 Da
- Length
- 631 Aa
Rv1272c doesn't seem to be a targeted by any drug.
Rv1272c doesn't seem to be involved in any pathway.
- The ABC transporter Rv1272c of Mycobacterium tuberculosis enhances the import of long-chain fatty acids in Escherichia coli.
- Biochem Biophys Res Commun. 2018 Feb 5;496(2):667-672. doi: 10.1016/j.bbrc.2018.01.115.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.