Gene - combatTB X

Rv1279

Type: protein_coding
Name: Rv1279
Locus Name: Rv1279
Product: Probable dehydrogenase FAD flavoprotein GMC oxidoreductase
Functional Category: Intermediary metabolism and respiration
Location: 1430062..1431648 (+ strand)
Gene Length: 1586 bp
Nucleotides: TGGACACTCAGAGCGACTACGTCGTGGTCGGTACCGGCTCAGCCGGGGCGGTTGTGGCCAGCCGGCTTAGCACCGATCCGGCCACGACGGTGGTGGCCCTGGAGGCGGGGCCGCGTGACAAGAACAGATTCATCGGCGTCCCAGCGGCGTTTTCCAAGCTGTTCCGCAGCGAGATCGACTGGGATTACCTAACCGAACCGCAGCCGGAGCTCGACGGCCGCGAAATCTATTGGCCTCGTGGCAAGGTGCTCGGTGGCTCGTCGTCCATGAACGCAATGATGTGGGTGCGTGGATTCGCATCAGACTACGATGAGTGGGCCGCGCGAGCCGGTCCGCGGTGGTCGTACGCCGACGTGCTCGGCTACTTTCGCCGCATCGAGAACGTCACCGCTGCCTGGCACTTTGTCAGCGGTGACGACAGCGGAGTAACCGGTCCGTTGCATATTTCCCGGCAACGCAGCCCAAGATCGGTGACCGCAGCGTGGCTGGCAGCCGCACGTGAGTGCGGATTTGCCGCTGCGCGGCCGAATTCCCCTCGACCGGAAGGCTTTTGCGAGACCGTCGTCACCCAGCGCCGCGGTGCTCGATTCAGTACTGCCGACGCCTATCTGAAGCCCGCGATGCGCCGTAAAAACCTCCGTGTGCTTACCGGCGCCACTGCTACCCGGGTGGTCATCGACGGCGACCGGGCCGTCGGCGTGGAATACCAAAGCGACGGTCAAACCCGCATCGTCTACGCCCGCCGCGAGGTGGTGCTCTGCGCTGGTGCCGTCAACAGCCCTCAGCTGCTGATGCTCTCCGGCATCGGCGACCGCGACCACCTCGCCGAACACGACATCGACACCGTTTACCACGCGCCCGAGGTCGGGTGCAACCTGCTCGATCATCTCGTCACGGTGCTGGGTTTCGACGTCGAAAAGGACAGCTTGTTTGCCGCCGAGAAGCCCGGCCAGTTGATCAGCTACTTACTGCGACGCCGCGGCATGCTCACCTCCAACGTCGGCGAGGCGTACGGATTTGTCCGCAGCCGACCCGAACTGAAGCTGCCCGATTTGGAGTTGATTTTTGCCCCGGCGCCGTTTTACGACGAAGCGCTGGTTCCACCGGCTGGTCACGGTGTGGTATTCGGCCCGATTCTGGTCGCGCCGCAAAGCCGTGGCCAGATCACGCTGCGGTCCGCCGATCCGCATGCCAAGCCTGTCATCGAACCGCGTTACCTGTCCGATCTCGGTGGCGTAGACCGGGCCGCCATGATGGCGGGCCTGCGGATATGCGCGCGGATCGCGCAGGCCCGCCCGCTCAGAGATCTCCTTGGGTCCATCGCGCGACCGCGCAACAGCACCGAGCTGGACGAGGCCACTCTCGAGTTGGCGCTGGCCACTTGTTCGCACACCCTGTACCACCCGATGGGCACCTGCCGCATGGGCAGCGACGAGGCCAGCGTGGTGGATCCGCAGCTGCGGGTCCGCGGTGTCGACGGACTCCGCGTCGCCGACGCGTCGGTGATGCCCAGCACGGTTCGTGGGCATACGCATGCGCCGTCGGTGCTGATCGGGGAGAAGGCCGCCGACTTAATCCGCAGCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

GMC oxidoreductase family

GO

cell wall GO:0005618 cellular_component
cytosol GO:0005829 cellular_component
plasma membrane GO:0005886 cellular_component
flavin adenine dinucleotide binding GO:0050660 molecular_function
oxidoreductase activity, acting on CH-OH group of donors GO:0016614 molecular_function

InterPro

UniProt: P9WMV5
GenBank: Rv1279
EnsemblBacteria: Rv1279
Mycobrowser: Rv1279

Summary

Name: Uncharacterized GMC-type oxidoreductase Rv1279 (EC 1.1.-.-)
Family: GMC oxidoreductase family
Protein Sequence: MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS
Mass: 57,331 Da
Length: 528 Aa

Rv1279 doesn't seem to be a targeted by any drug.

Rv1279 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.