Gene - combatTB X

oppA

Type: protein_coding
Name: oppA
Locus Name: Rv1280c
Product: Probable periplasmic oligopeptide-binding lipoprotein OppA
Functional Category: Cell wall and cell processes
Location: 1431665..1433440 (- strand)
Gene Length: 1775 bp
Nucleotides: GTGGCTGACCGTGGCCAGCGACGAGGCTGCGCCCCGGGCATCGCGTCTGCGCTCAGGGCGTCGTTTCAGGGGAAATCCAGACCCTGGACGCAGACTCGATATTGGGCTTTCGCGTTATTAACACCGCTCGTCGTGGCTATGGTGCTCACCGGATGCTCGGCCTCCGGTACCCAACTCGAACTCGCGCCCACTGCGGACCGCAGGGCCGCGGTTGGCACCACCAGCGACATCAATCAGCAGGATCCCGCCACGTTGCAAGACGGCGGCAATCTTCGCCTGTCGCTCACCGACTTTCCGCCCAACTTCAACATCTTGCACATCGACGGCAACAACGCCGAGGTCGCGGCGATGATGAAAGCCACCTTGCCGCGCGCGTTCATCATCGGACCGGACGGCTCGACGACGGTCGACACCAACTACTTCACCAGCATCGAGCTGACCAGGACCGCCCCGCAGGTGGTCACCTACACCATCAATCCCGAGGCGGTGTGGTCCGACGGGACCCCGATCACCTGGCGGGACATCGCCAGCCAGATTCATGCGATCAGCGGCGCCGACAAGGCATTCGAGATCGCTTCTAGCAGCGGCGCCGAGCGTGTGGCGTCGGTAACCAGAGGGGTCGACGACCGGCAGGCCGTGGTGACGTTCGCCAAGCCGTACGCGGAGTGGCGCGGTATGTTCGCGGGCAACGGCATGCTGCTGCCGGCCAGTATGACCGCCACACCCGAGGCATTCAATAAGGGTCAACTCGATGGGCCCGGTCCGTCGGCGGGTCCGTTCGTCGTGTCTGCCCTGGACCGCACCGCGCAGCGAATCGTGTTGACCCGTAACCCGAGATGGTGGGGGGCACGGCCACGCCTGGACAGCATCACATACCTGGTGCTCGATGATGCCGCCCGGCTGCCGGCGCTGCAGAACAACACAATCGACGCCACCGGCGTCGGCACACTGGACCAGCTGACCATCGCGGCGCGCACCAAGGGCATCTCGATCCGGCGCGCCCCCGGGCCCAGCTGGTATCACTTCACCCTCAACGGTGCGCCTGGGTCGATCCTCGCCGACAAGGCGCTGCGCCTGGCGATCGCCAAGGGCATCGACCGATACACCATCGCCAGGGTCGCCCAATACGGCCTCACCAGCGACCCGGTGCCACTGAACAACCACGTCTTCGTCGCCGGCCAAGACGGCTACCAGGACAACAGCGGCGTTGTCGCCTACAACCCGGAACAAGCGAAACGGGAGCTGGACGCCCTGGGCTGGAGGCGAAGCGGCGCGTTCCGGGAGAAGGACGGTCGCCAGCTCGTCATCCGCGATCTGTTCTACGACGCACAAAGCACCCGGCAGTTCGCCCAGATCGCCCAACACACCCTGGCGCAGATCGGCGTCAAACTCGAACTTCAGGCCAAGTCCGGCAGCGGTTTCTTCAGCGACTACGTCAACGTGGGGGCTTTCGACATCGCACAGTTCGGCTGGGTGGGCGACGCGTTTCCGCTGTCATCGCTCACCCAGATCTACGCTTCGGACGGGGAAAGCAACTTCGGCAAGATCGGTAGCCCGCAAATCGACGCCGCGATCGAGCGAACGCTGGCAGAACTCGATCCCGGCAAGGCGAGGGCCTTGGCCAACCAGGTCGACGAGCTGATCTGGGCCGAAGGATTCAGCCTGCCGCTTACCCAGTCGCCCGGCACCGTTGCGGTCCGCAGCACGCTGGCCAACTTCGGCGCGACGGGTCTGGCAGACCTGGACTACACCGCCATCGGGTTCATGCGACGCTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Bacterial solute-binding protein 5 family

GO

peptide transmembrane transporter activity GO:1904680 molecular_function
outer membrane-bounded periplasmic space GO:0030288 cellular_component
peptide binding GO:0042277 molecular_function
glutathione binding GO:0043295 molecular_function
protein import GO:0017038 biological_process
integral component of plasma membrane GO:0005887 cellular_component
periplasmic space GO:0042597 cellular_component
ATP-binding cassette (ABC) transporter complex GO:0043190 cellular_component
plasma membrane GO:0005886 cellular_component
evasion or tolerance by symbiont of host-produced nitric oxide GO:0052060 biological_process

InterPro

UniProt: P9WGU5
GenBank: Rv1280c
EnsemblBacteria: Rv1280c
Mycobrowser: Rv1280c

Summary

Name: Uncharacterized protein Rv1280c
Family: Bacterial solute-binding protein 5 family
Protein Sequence: MADRGQRRGCAPGIASALRASFQGKSRPWTQTRYWAFALLTPLVVAMVLTGCSASGTQLELAPTADRRAAVGTTSDINQQDPATLQDGGNLRLSLTDFPPNFNILHIDGNNAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTRTAPQVVTYTINPEAVWSDGTPITWRDIASQIHAISGADKAFEIASSSGAERVASVTRGVDDRQAVVTFAKPYAEWRGMFAGNGMLLPASMTATPEAFNKGQLDGPGPSAGPFVVSALDRTAQRIVLTRNPRWWGARPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAARTKGISIRRAPGPSWYHFTLNGAPGSILADKALRLAIAKGIDRYTIARVAQYGLTSDPVPLNNHVFVAGQDGYQDNSGVVAYNPEQAKRELDALGWRRSGAFREKDGRQLVIRDLFYDAQSTRQFAQIAQHTLAQIGVKLELQAKSGSGFFSDYVNVGAFDIAQFGWVGDAFPLSSLTQIYASDGESNFGKIGSPQIDAAIERTLAELDPGKARALANQVDELIWAEGFSLPLTQSPGTVAVRSTLANFGATGLADLDYTAIGFMRR
Mass: 63,477 Da
Length: 591 Aa

Rv1280c doesn't seem to be a targeted by any drug.

Tolerance by Mtb to nitric oxide produced by macrophages R-HSA-1222538
Homo sapiens
R-HSA-1222538

Quorum sensing mtu02024
mtu02024
Cellular Processes; Cellular community - prokaryotes

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.