thrA
- Type
- protein_coding
- Name
- thrA
- Locus Name
-
Rv1294
- Product
-
Probable homoserine dehydrogenase ThrA
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1449375..1450700 (+ strand)
- Gene Length
- 1325 bp
- Nucleotides
-
TGCCCGGTGACGAAAAGCCGGTCGGCGTAGCGGTACTCGGTTTGGGCAACGTCGGCAGCGAGGTTGTCCGCATCATCGAGAACAGCGCCGAGGATCTCGCGGCTCGTGTCGGTGCCCCATTGGTCCTGCGGGGCATCGGCGTGCGCCGCGTGACGACCGATCGCGGCGTGCCGATCGAATTGTTGACCGACGACATTGAAGAGCTCGTGGCCCGCGAGGATGTCGATATCGTGGTGGAAGTGATGGGGCCGGTGGAACCGTCGCGCAAGGCGATCCTGGGCGCCCTTGAGCGCGGCAAGTCCGTCGTTACGGCGAACAAGGCTTTACTCGCCACCTCCACCGGCGAATTGGCACAGGCCGCCGAAAGCGCCCATGTTGATCTGTATTTCGAGGCGGCCGTGGCGGGCGCCATTCCGGTCATCCGTCCGCTCACCCAGTCGCTGGCCGGCGACACGGTGCTGCGAGTGGCCGGGATCGTCAACGGCACCACCAACTACATCCTCTCGGCGATGGACAGCACCGGCGCTGACTATGCCAGCGCCCTGGCCGACGCAAGTGCGCTGGGCTATGCGGAGGCTGATCCCACCGCAGACGTCGAAGGCTACGACGCCGCGGCCAAGGCAGCGATCCTGGCATCCATTGCCTTCCACACCCGGGTGACCGCAGACGACGTGTATCGCGAAGGCATCACCAAGGTCACTCCGGCCGACTTCGGATCCGCGCACGCGCTGGGTTGCACCATCAAACTGCTGTCGATCTGTGAGCGCATAACCACCGACGAAGGTTCGCAGCGGGTATCGGCCCGCGTCTATCCGGCCCTGGTACCTCTGTCGCATCCGCTTGCCGCGGTCAACGGCGCGTTCAATGCCGTGGTGGTCGAGGCCGAGGCCGCGGGCCGGCTGATGTTCTACGGCCAGGGCGCGGGCGGCGCGCCGACCGCCTCTGCGGTGACCGGTGACCTAGTGATGGCCGCCCGCAACCGGGTACTCGGCAGCCGCGGCCCCCGTGAGTCTAAATACGCTCAACTTCCGGTGGCACCAATGGGTTTCATTGAAACGCGCTATTACGTCAGCATGAACGTCGCCGACAAGCCGGGCGTCTTGTCCGCGGTGGCGGCGGAATTCGCCAAACGCGAGGTGAGCATCGCCGAGGTGCGCCAGGAGGGCGTTGTGGACGAAGGTGGTCGACGGGTGGGAGCCCGAATCGTGGTGGTCACGCACCTCGCCACTGACGCCGCACTCTCGGAAACCGTTGATGCACTGGACGACTTGGATGTCGTGCAGGGTGTGTCCAGCGTGATACGACTGGAAGGAACCGGCTTATGA
- Drug Resistance
- Mutations
- Function
- Unknown
- Family
-
Homoserine dehydrogenase family
- GO
-
- homoserine dehydrogenase activity GO:0004412 molecular_function
- NADP binding GO:0050661 molecular_function
- plasma membrane GO:0005886 cellular_component
- cell wall GO:0005618 cellular_component
- methionine biosynthetic process GO:0009086 biological_process
- threonine biosynthetic process GO:0009088 biological_process
- isoleucine biosynthetic process GO:0009097 biological_process
- InterPro
Summary
- Name
- Homoserine dehydrogenase (HDH) (EC 1.1.1.3)
- Family
- Homoserine dehydrogenase family
- Protein Sequence
-
MPGDEKPVGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRGIGVRRVTTDRGVPIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVTANKALLATSTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKVTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPLAAVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPRESKYAQLPVAPMGFIETRYYVSMNVADKPGVLSAVAAEFAKREVSIAEVRQEGVVDEGGRRVGARIVVVTHLATDAALSETVDALDDLDVVQGVSSVIRLEGTGL
- Mass
- 45,553 Da
- Length
- 441 Aa
Rv1294 doesn't seem to be a targeted by any drug.
-
-
Cysteine and methionine metabolism mtu00270
mtu00270Metabolism; Amino acid metabolism
-
-
-
Glycine, serine and threonine metabolism mtu00260
mtu00260Metabolism; Amino acid metabolism
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
- BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.