atpA
- Type
- protein_coding
- Name
- atpA
- Locus Name
-
Rv1308
- Product
-
Probable ATP synthase alpha chain AtpA
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1463228..1464877 (+ strand)
- Gene Length
- 1649 bp
- Nucleotides
-
TGGCTGAGTTGACAATCCCCGCTGATGACATCCAGAGCGCAATCGAAGAGTACGTAAGCTCTTTCACCGCCGACACCAGTAGAGAGGAAGTCGGTACCGTCGTCGATGCCGGGGACGGCATCGCACACGTCGAGGGTTTGCCATCGGTGATGACCCAAGAGCTGCTCGAATTCCCGGGCGGAATCCTCGGCGTCGCCCTCAACCTCGACGAGCACAGCGTCGGCGCGGTGATCCTCGGTGACTTCGAGAACATCGAAGAAGGTCAGCAGGTCAAGCGCACCGGCGAAGTCTTATCGGTTCCGGTTGGCGACGGGTTTTTGGGGCGGGTGGTTAACCCGCTCGGCCAGCCGATCGACGGGCGCGGAGACGTCGACTCCGATACTCGGCGCGCGCTGGAGCTCCAGGCGCCCTCGGTGGTGCACCGGCAAGGCGTGAAGGAGCCGTTGCAGACCGGGATCAAGGCGATTGACGCGATGACCCCGATCGGCCGCGGCCAGCGCCAGCTGATCATCGGCGACCGCAAGACCGGCAAAACCGCCGTCTGCGTCGACACCATCCTCAACCAGCGGCAGAACTGGGAGTCCGGTGATCCCAAGAAGCAGGTGCGCTGTGTATACGTGGCCATCGGGCAGAAGGGAACTACCATCGCCGCGGTACGCCGCACACTGGAAGAGGGCGGTGCGATGGACTACACCACCATCGTCGCGGCCGCGGCGTCGGAGTCCGCCGGTTTCAAATGGCTTGCGCCGTACACCGGTTCGGCGATCGCCCAGCACTGGATGTACGAGGGCAAGCATGTGCTGATCATCTTCGACGACCTGACTAAGCAGGCCGAGGCATACCGGGCGATCTCGCTGCTGCTGCGCCGTCCGCCCGGCCGTGAGGCCTACCCCGGCGATGTGTTCTATCTGCATTCGCGGCTTTTGGAGCGCTGCGCCAAACTGTCCGACGATCTCGGTGGCGGCTCGCTAACGGGTCTGCCGATCATCGAGACCAAGGCCAACGACATCTCGGCCTACATCCCGACCAACGTCATCTCGATCACCGACGGGCAATGTTTCCTGGAAACCGACCTGTTCAACCAGGGCGTCCGGCCGGCCATCAACGTCGGTGTGTCGGTGTCCCGAGTCGGCGGCGCGGCGCAGATCAAGGCTATGAAAGAGGTCGCCGGAAGCCTCCGCTTGGACCTTTCGCAATACCGCGAGCTAGAAGCTTTCGCCGCTTTCGCTTCTGATTTGGACGCCGCATCGAAGGCGCAGTTGGAGCGCGGCGCCCGGCTGGTCGAGCTGCTCAAGCAGCCGCAATCCCAGCCCATGCCCGTTGAGGAGCAAGTGGTTTCGATCTTCCTGGGCACCGGCGGTCACCTGGACTCGGTGCCCGTCGAGGACGTCCGGCGGTTCGAAACCGAATTACTGGACCACATGCGGGCCTCCGAAGAAGAGATTTTGACTGAGATCCGGGACAGCCAAAAGCTCACCGAGGAGGCCGCCGACAAGCTCACCGAGGTCATCAAGAACTTCAAGAAGGGCTTCGCGGCCACCGGTGGCGGCTCTGTGGTGCCCGACGAACATGTCGAGGCCCTCGACGAGGATAAGCTCGCCAAGGAAGCCGTGAAGGTCAAAAAGCCGGCGCCGAAGAAGAAGAAATAG
- Drug Resistance
- Mutations
- Function
- Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. {ECO:0000255|HAMAP-Rule:MF_01346}.
- Family
-
ATPase alpha/beta chains family
- GO
-
- proton-transporting ATP synthase activity, rotational mechanism GO:0046933 molecular_function
- ATP synthesis coupled proton transport GO:0015986 biological_process
- cell wall GO:0005618 cellular_component
- ATP binding GO:0005524 molecular_function
- plasma membrane GO:0005886 cellular_component
- proton-transporting ATP synthase complex, catalytic core F(1) GO:0045261 cellular_component
- ADP binding GO:0043531 molecular_function
- InterPro
Summary
- Name
- ATP synthase subunit alpha (EC 7.1.2.2) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha)
- Family
- ATPase alpha/beta chains family
- Protein Sequence
-
MAELTIPADDIQSAIEEYVSSFTADTSREEVGTVVDAGDGIAHVEGLPSVMTQELLEFPGGILGVALNLDEHSVGAVILGDFENIEEGQQVKRTGEVLSVPVGDGFLGRVVNPLGQPIDGRGDVDSDTRRALELQAPSVVHRQGVKEPLQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDPKKQVRCVYVAIGQKGTTIAAVRRTLEEGGAMDYTTIVAAAASESAGFKWLAPYTGSAIAQHWMYEGKHVLIIFDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDDLGGGSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFAAFASDLDAASKAQLERGARLVELLKQPQSQPMPVEEQVVSIFLGTGGHLDSVPVEDVRRFETELLDHMRASEEEILTEIRDSQKLTEEAADKLTEVIKNFKKGFAATGGGSVVPDEHVEALDEDKLAKEAVKVKKPAPKKKK
- Mass
- 59,288 Da
- Length
- 549 Aa
Rv1308 doesn't seem to be a targeted by any drug.
-
-
Oxidative phosphorylation mtu00190
mtu00190PATHWAY_MAP mtu00190 Oxidative phosphorylation
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
- PLoS One. 2010 Jan 6;5(1):e8589. doi: 10.1371/journal.pone.0008589.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.