Gene - combatTB X

Rv1319c

Type: protein_coding
Name: Rv1319c
Locus Name: Rv1319c
Product: Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase)
Functional Category: Intermediary metabolism and respiration
Location: 1480894..1482501 (- strand)
Gene Length: 1607 bp
Nucleotides: ATGCCGGCGAAAAAGACCATGGCGCAACGCCTGGGCCAGGCACTCGAGACGATGACCCGTCAGTGCGGCCAGCTGCCCGAGACCCCGGCGTATGGCTCCTGGTTGCTTGGGCGGGTGTCAGAAAGCCCGTCGCGTCGCTGGGTACGCATCAAGCGCATCGTGACCGTCTATATCATGACGGCGAACCTGACCGGGATCGTGGTCGCGCTGCTAGTGGTGACCTTCGCTTTTCCGGTGCCTAGCATCTACACCGACGCCCCATGGTGGGTCACCTTCGGGGTCGCACCGGCCTATGCGACGCTCGCACTGGCCATCGGCACCTACTGGATAACCACGCGAATCGTCAGAGCGTCCATACGGTGGGCGATCGAGGAACGCGCGCCGAGCCAGGCCGACGGGCGCAACACCTTGCTGCTCCCGTTTCGAGTGGCAGCCGTCCACCTCATTCTGTGGGATATCGGCGGGGCGTTGTTGGCCACGCTCTACGGGCTGGCCAACCGCGTATTCGTCACCATAATTTTGTTCTCGGTGACTATCTGCGGCGTTTTGGTAGCCACCAATTGCTACTTGTTCACCGAGTTCGCGCTGCGACCCGTAGCCGCTAAAGCACTCGAAGCGGGACGACCGCCACGACGGTTTGCACCGGGCATCATGGGCCGAACGATGACGGTGTGGTCGCTAGGTTCAGGCGTGCCTGTGACCGGCATCGCCACGACAGCGCTCTACGTCCTATTGGTGCACAATCTGACCGAAACGCAGCTCGCGTCGGCGGTGTTGATCCTGTCGATAACCACGTTGATCTTCGGGTTTCTCGTGATGTGGATTCTTGCTTGGCTGACGGCGGCGCCGGTGCGAGTGGTGCGCGCTGCGCTCAAGCGTGTCGAGCAGGGGGATCTGCGAGGGGATCTGGTGGTGTTCGACGGCACCGAACTCGGTGAGCTGCAGCGTGGTTTCAACGCGATGGTCAACGGCCTGCGCGAGCGCGAACGCGTGCGCGACCTTTTCGGCCGCCACGTCGGACGCGAAGTCGCCGCCGCCGCCGAGCGTGAACGACCACAGCTAGGCGGCGAAGACCGCCACGCCGCCGTCGTCTTCGTCGACATCGTCGGCTCCACCCAGCTGGTGGACAACCAACCTGCCGCCCACGTGGTCAAGCTCCTCAACCGGTTTTTCGCGATCGTCGTCAACGAGGTCGACCGTCACCACGGACTGATCAACAAGTTCGCAGGCGACGCCGCCCTGGCCATCTTCGGAGCCCCGAACCGCCTCGACCGTCCCGAAGACGCCGCGCTGGCCGCCGCCCGGGCCATAGCCGATCGGCTGGCCAACGAGATGCCCGAGGTCCAAGCCGGCATCGGGGTGGCGGCAGGCCAGATCGTCGCCGGCAATGTCGGCGCCAAGCAAAGATTCGAATACACAGTGGTCGGCAAGCCGGTCAACCAGGCGGCCCGATTGTGCGAACTGGCCAAATCACACCCCGCGCGATTGCTAGCATCCTCGGACACACTGCACGCTGCCAGCGAAACCGAACGTGCCCATTGGTCTTTGGGCGAGACGGTGACGCTGCGCGGACATGAGCAGCCGACTCGGCTGGCCGTGCCCACCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Adenylyl cyclase class-3 family

GO

extracellular region GO:0005576 cellular_component
plasma membrane GO:0005886 cellular_component
intracellular signal transduction GO:0035556 biological_process
cAMP biosynthetic process GO:0006171 biological_process
integral component of membrane GO:0016021 cellular_component
adenylate cyclase activity GO:0004016 molecular_function

InterPro

UniProt: P9WQ31
GenBank: Rv1319c
EnsemblBacteria: Rv1319c
Mycobrowser: Rv1319c

Summary

Name: Uncharacterized protein Rv1319c
Family: Adenylyl cyclase class-3 family
Protein Sequence: MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT
Mass: 58,098 Da
Length: 535 Aa

Rv1319c doesn't seem to be a targeted by any drug.

Purine metabolism mtu00230
mtu00230
PATHWAY_MAP mtu00230 Purine metabolism

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.