glgB
- Type
- protein_coding
- Name
- glgB
- Locus Name
-
Rv1326c
- Product
-
1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme)
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1490117..1492312 (- strand)
- Gene Length
- 2195 bp
- Nucleotides
-
ATGAGTCGATCCGAGAAACTCACCGGGGAGCACCTTGCACCCGAGCCGGCCGAAATGGCGCGCTTGGTGGCGGGTACACATCACAACCCGCACGGCATCCTGGGCGCCCACGAATACGACGACCATACCGTCATCCGAGCGTTCCGTCCGCATGCCGTCGAGGTCGTCGCGCTCGTTGGTAAGGACCGGTTCTCGTTGCAGCACCTCGATTCTGGCCTGTTTGCCGTCGCATTGCCGTTCGTCGACCTCATCGACTACCGCCTGCAGGTGACCTATGAAGGTTGCGAGCCACACACCGTGGCCGATGCGTACCGATTCCTGCCCACCCTGGGCGAGGTCGACCTGCACCTGTTCGCCGAGGGCCGCCACGAACGGCTTTGGGAAGTCCTGGGTGCCCACCCCCGCTCGTTTACCACGGCCGACGGTGTGGTGAGTGGCGTGTCGTTCGCCGTGTGGGCGCCCAACGCCAAGGGCGTCAGCTTGATCGGCGAGTTCAACGGTTGGAATGGCCACGAAGCCCCCATGCGGGTGCTCGGCCCATCAGGGGTATGGGAATTGTTCTGGCCCGACTTCCCTTGCGACGGTCTGTACAAGTTCCGCGTGCACGGCGCCGACGGCGTGGTTACCGATCGGGCCGACCCGTTCGCGTTCGGCACCGAGGTGCCGCCGCAGACCGCATCGCGGGTGACGTCGAGTGACTACACCTGGGGTGACGACGACTGGATGGCTGGGCGTGCGCTGCGCAACCCGGTGAACGAGGCGATGAGCACCTACGAAGTCCATCTCGGTTCGTGGCGGCCTGGACTCAGCTACCGCCAGCTTGCTCGTGAGTTGACGGATTACATTGTGGATCAAGGGTTTACCCATGTGGAGCTGTTGCCCGTCGCCGAGCATCCATTCGCCGGATCATGGGGGTATCAGGTCACGTCCTACTATGCGCCGACATCACGATTCGGCACACCCGACGACTTCCGGGCGCTGGTCGACGCCCTGCACCAGGCCGGCATCGGCGTCATCGTGGATTGGGTCCCAGCGCACTTCCCGAAGGACGCGTGGGCCCTGGGACGGTTCGACGGCACTCCGCTCTACGAACATTCCGATCCCAAACGCGGCGAGCAACTGGATTGGGGCACATACGTGTTCGACTTCGGCCGCCCGGAAGTGCGCAACTTTCTGGTAGCCAATGCGTTGTACTGGCTACAGGAGTTCCACATCGACGGCCTGCGGGTGGACGCGGTGGCCTCAATGCTCTATCTAGACTACTCGCGACCCGAGGGCGGCTGGACCCCCAACGTCCACGGCGGCCGGGAGAACCTGGAAGCAGTGCAGTTCCTGCAGGAGATGAACGCCACGGCGCACAAGGTCGCGCCGGGAATCGTCACCATCGCCGAGGAGTCCACGCCGTGGTCTGGGGTGACCCGCCCGACCAACATTGGCGGCCTGGGCTTTTCGATGAAGTGGAACATGGGCTGGATGCACGACACGCTCGACTACGTCAGCCGAGATCCGGTGTACCGCAGCTACCACCACCACGAGATGACGTTCTCGATGCTGTATGCGTTCAGCGAAAATTACGTGTTGCCGCTCAGTCATGACGAGGTGGTGCACGGCAAAGGCACGCTGTGGGGGCGGATGCCGGGCAACAATCACGTCAAGGCCGCCGGCCTGCGTAGCCTGCTTGCCTACCAATGGGCACACCCCGGCAAGCAATTGCTGTTCATGGGTCAGGAATTCGGCCAACGCGCCGAATGGTCCGAGCAGCGCGGCCTGGACTGGTTCCAACTCGACGAAAACGGCTTCTCCAACGGGATTCAGCGGCTGGTGCGCGACATCAACGACATCTACCGATGCCACCCGGCGCTGTGGAGCTTAGACACCACCCCCGAAGGCTATTCTTGGATCGACGCCAACGACTCCGCCAACAATGTGTTGAGCTTTATGCGCTACGGCAGCGACGGCTCGGTGCTGGCCTGCGTGTTCAATTTCGCAGGTGCCGAACACCGTGACTATCGACTCGGGCTGCCGCGCGCGGGCCGCTGGCGCGAGGTGCTCAATACCGACGCGACGATCTACCACGGCTCAGGGATCGGCAACCTCGGCGGCGTGGACGCCACCGACGACCCCTGGCATGGCCGCCCGGCGTCCGCGGTGCTGGTGCTGCCGCCCACTTCGGCGCTGTGGCTGACGCCCGCCTA
- Drug Resistance
- Mutations
- Function
- Essential enzyme that catalyzes the formation of the alpha-1,6-glucosidic linkages in glucan chains by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan. {ECO:0000269|PubMed:17005418, ECO:0000269|PubMed:18808383}.
- Family
-
Glycosyl hydrolase 13 family, GlgB subfamily
- GO
-
- glucan biosynthetic process GO:0009250 biological_process
- 1,4-alpha-glucan branching enzyme activity GO:0003844 molecular_function
- glycogen biosynthetic process GO:0005978 biological_process
- carbohydrate metabolic process GO:0005975 biological_process
- cytosol GO:0005829 cellular_component
- cation binding GO:0043169 molecular_function
- plasma membrane GO:0005886 cellular_component
- capsule polysaccharide biosynthetic process GO:0045227 biological_process
- hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 molecular_function
- 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) GO:0102752 molecular_function
- InterPro
3K1D
- Name
- 1,4-alpha-glucan branching enzyme GlgB (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Glycogen-branching enzyme) (BE)
- Family
- Glycosyl hydrolase 13 family, GlgB subfamily
- Protein Sequence
-
MSRSEKLTGEHLAPEPAEMARLVAGTHHNPHGILGAHEYDDHTVIRAFRPHAVEVVALVGKDRFSLQHLDSGLFAVALPFVDLIDYRLQVTYEGCEPHTVADAYRFLPTLGEVDLHLFAEGRHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVSLIGEFNGWNGHEAPMRVLGPSGVWELFWPDFPCDGLYKFRVHGADGVVTDRADPFAFGTEVPPQTASRVTSSDYTWGDDDWMAGRALRNPVNEAMSTYEVHLGSWRPGLSYRQLARELTDYIVDQGFTHVELLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQAGIGVIVDWVPAHFPKDAWALGRFDGTPLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFLVANALYWLQEFHIDGLRVDAVASMLYLDYSRPEGGWTPNVHGGRENLEAVQFLQEMNATAHKVAPGIVTIAEESTPWSGVTRPTNIGGLGFSMKWNMGWMHDTLDYVSRDPVYRSYHHHEMTFSMLYAFSENYVLPLSHDEVVHGKGTLWGRMPGNNHVKAAGLRSLLAYQWAHPGKQLLFMGQEFGQRAEWSEQRGLDWFQLDENGFSNGIQRLVRDINDIYRCHPALWSLDTTPEGYSWIDANDSANNVLSFMRYGSDGSVLACVFNFAGAEHRDYRLGLPRAGRWREVLNTDATIYHGSGIGNLGGVDATDDPWHGRPASAVLVLPPTSALWLTPA
- Mass
- 81,729 Da
- Length
- 731 Aa
Summary
Rv1326c doesn't seem to be a targeted by any drug.
-
-
Starch and sucrose metabolism mtu00500
mtu00500PATHWAY_MAP mtu00500 Starch and sucrose metabolism
-
- Crystal structure of full-length Mycobacterium tuberculosis H37Rv glycogen branching enzyme: insights of N-terminal beta-sandwich in substrate specificity and enzymatic activity.
- J Biol Chem. 2010 Jul 2;285(27):20897-903. doi: 10.1074/jbc.M110.121707. Epub 2010 May 5.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Redox biology of Mycobacterium tuberculosis H37Rv: protein-protein interaction between GlgB and WhiB1 involves exchange of thiol-disulfide.
- BMC Biochem. 2009 Jan 5;10:1. doi: 10.1186/1471-2091-10-1.
- Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice.
- Mol Microbiol. 2008 Nov;70(3):762-74. doi: 10.1111/j.1365-2958.2008.06445.x. Epub 2008 Sep 18.
- Expression and characterization of alpha-(1,4)-glucan branching enzyme Rv1326c of Mycobacterium tuberculosis H37Rv.
- Protein Expr Purif. 2007 Feb;51(2):198-208. doi: 10.1016/j.pep.2006.08.005. Epub 2006 Aug 22.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.