pncB1
- Type
- protein_coding
- Name
- pncB1
- Locus Name
-
Rv1330c
- Product
-
Nicotinic acid phosphoribosyltransferase PncB1
- Functional Category
-
Intermediary metabolism and respiration
- Location
- 1499213..1500559 (- strand)
- Gene Length
- 1346 bp
- Nucleotides
-
GTGGGGCCACCCCCAGCCGCCAGGCGGCGAGAGGGAGAGCCCGACAATCAAGACCCAGCCGGGCTGTTGACCGACAAGTACGAGTTGACCATGCTGGCGGCTGCCCTGCGCGACGGCAGCGCCAATCGCCCCACCACATTCGAGGTGTTCGCTCGCCGACTCCCCACCGGCCGTCGCTACGGAGTTGTCGCCGGAACCGGCCGGTTGCTGGAAGCGTTGCCGCAGTTCAGGTTCGACGCTGACGCGTGCGAGTTGCTGGCCCAATTCCTCGACCCGGCCACGGTGCGGTATCTTCGCGAATTCCGGTTCCGCGGCGATATCGACGGCTATGCCGAGGGGGAGCTGTATTTTCCCGGGTCACCGGTGCTCTCGGTACGCGGCAGCTTCGCCGAATGCGTCCTGCTCGAAACGCTGGTGCTGTCAATCTTCAACCACGACACAGCGATCGCCTCGGCAGCGGCGCGCATGGTCAGCGCCGCCGGGGGGCGCCCACTGATCGAGATGGGCTCGCGGCGCACCCACGAACGCGCCGCGGTGGCAGCGGCCCGGGCGGCGTATATCGCCGGTTTCGCCGCGTCATCCAACTTGGCGGCGCAGCGACGCTACGGAGTGCCCGCGCACGGCACCGCGGCACACGCATTCACCATGTTGCACGCCCAGCATGGCGGCCCCACCGAACTAGCCGAGCGAGCCGCATTCCGCGCCCAGGTCGAAGCGCTGGGACCCGGTACCACGCTGCTGGTGGATACCTATGACGTCACGACCGGTGTGGCCAATGCCGTTGCCGCCGCCGGCGCTGAGCTCGGCGCGATCCGCATCGATTCCGGTGAGCTTGGGGTACTGGCCCGCCAAGCGCGGGAGCAGCTCGACCGGCTAGGAGCCACCCGGACGCGCATCGTGGTGTCCGGCGACCTTGACGAGTTCAGCATCGCCGCGTTGCGCGGTGAACCCGTCGACAGCTACGGCGTGGGCACGTCGCTGGTCACCGGGTCGGGCGCGCCGACCGCCAACATGGTCTACAAACTGGTCGAGGTAGACGGTGTACCGGTGCAAAAGCGCAGCAGCTACAAAGAATCCCCCGGCGGCCGCAAAGAGGCACTGCGGCGCTCCCGTGCGACGGGCACCATCACCGAGGAGCTCGTGCATCCGGCGGGCCGTCCGCCGGTCATTGTCGAGCCGCACCGGGTTTTGACGCTGCCACTGGTCCGCGCCGGGCAACCGGTAGCCGATACCAGCCTGGCCGCGGCACGGCAGCTGGTGGCATCCGGGTTGCGCAGCCTGCCAGGCGACGGGCTGAAATTGGCACCCGGCGAGCCGGCGATTCCGACACGCACGATCCCGGCCTG
- Drug Resistance
- Mutations
- Function
- Involved in the Preiss-Handler pathway, which is a recycling route that permits the salvage of free nicotinamide (NM) and nicotinic acid (Na) involved in the NAD biosynthesis. Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. It is not able to use nicotinamide. PncB1 contributes to basal NAD level. {ECO:0000269|PubMed:18490451}.
- Family
-
NAPRTase family
- GO
-
- nicotinate nucleotide salvage GO:0019358 biological_process
- NAD biosynthetic process GO:0009435 biological_process
- NAD salvage GO:0034355 biological_process
- cell wall GO:0005618 cellular_component
- cytosol GO:0005829 cellular_component
- nicotinamide phosphoribosyltransferase activity GO:0047280 molecular_function
- nicotinate phosphoribosyltransferase activity GO:0004516 molecular_function
- nicotinate-nucleotide diphosphorylase (carboxylating) activity GO:0004514 molecular_function
- InterPro
Summary
- Name
- Nicotinate phosphoribosyltransferase pncB1 (NAPRTase pncB1) (EC 6.3.4.21)
- Family
- NAPRTase family
- Protein Sequence
-
MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEALGPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLVASGLRSLPGDGLKLAPGEPAIPTRTIPA
- Mass
- 47,227 Da
- Length
- 448 Aa
Rv1330c doesn't seem to be a targeted by any drug.
Rv1330c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
- J Biol Chem. 2008 Jul 11;283(28):19329-41. doi: 10.1074/jbc.M800694200. Epub 2008 May 19.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.