mbtM
- Type
- protein_coding
- Name
- mbtM
- Locus Name
-
Rv1345
- Product
-
Probable fatty acyl-AMP ligase MbtM
- Functional Category
-
Lipid metabolism
- Location
- 1509281..1510846 (+ strand)
- Gene Length
- 1565 bp
- Nucleotides
-
TGAGTGAGCTCGCGGCCGTGCTCACGCGGTCCATGCAGGCCTCTGCCGGCGACTTGATGGTCCTCGACCGCGAGACCTCGCTGTGGTGTCGGCACCCGTGGCCCGAGGTACACGGGCTGGCCGAGAGCGTAGCGGCCTGGCTGCTAGACCATGACCGACCCGCCGCGGTGGGTCTGGTCGGCGAACCGACGGTCGAGTTGGTCGCCGCGATCCAGGGTGCCTGGCTTGCCGGCGCTGCCGTGTCGATCCTGCCCGGGCCGGTACGTGGCGCCAATGACCAGCGATGGGCGGACGCGACGTTGACCCGTTTCCTCGGGATTGGGGTGCGCACCGTATTGAGCCAGGGTTCCTACCTTGCCCGCCTGCGATCGGTCGATACGGCCGGCGTAACGATCGGAGATCTCAGCACGGCGGCGCACACCAATCGTTCGGCCACACCGGTGGCGAGTGAAGGGCCCGCGGTCCTTCAAGGTACCGCGGGATCGACGGGCGCGCCCCGTACCGCCATCCTTTCGCCGGGCGCGGTGCTCAGCAACTTGCGTGGGCTCAATCAGCGCGTGGGCACCGATGCTGCGACCGACGTCGGTTGCTCATGGTTACCGCTGTACCACGACATGGGGCTCGCTTTCGTGCTCTCTGCTGCGCTGGCCGGTGCGCCGCTCTGGTTGGCCCCGACGACGGCGTTCACGGCGTCGCCGTTCCGTTGGTTGAGTTGGCTCTCGGACAGTGGTGCCACCATGACCGCGGCACCGAACTTCGCCTACAACCTCATCGGCAAATACGCCAGGCGGGTATCCGAGGTCGACCTGGGTGCCCTGCGAGTGACGCTCAACGGTGGAGAGCCGGTTGACTGCGATGGGCTGACGCGGTTCGCGGAGGCGATGGCACCGTTCGGATTCGATGCCGGCGCCGTGTTGCCCTCCTACGGGCTCGCCGAGTCGACGTGCGCGGTGACCGTGCCGGTCCCCGGAATTGGGTTGCTTGCCGACCGTGTCATCGACGGCAGCGGTGCGCATAAGCACGCGGTCCTGGGTAACCCCATCCCCGGTATGGAGGTACGGATCTCGTGCGGTGATCAGGCGGCAGGCAATGCGAGCCGTGAAATTGGCGAAATCGAGATTCGCGGTGCGTCGATGATGGCGGGTTACCTGGGTCAGCAGCCGATCGACCCTGACGATTGGTTTGCCACCGGCGACCTCGGCTATCTTGGCGCTGGCGGCCTGGTGGTGTGTGGTCGCGCGAAGGAAGTCATCTCCATCGCGGGACGCAACATCTTTCCGACGGAGGTCGAGCTGGTGGCAGCGCAAGTTCGCGGAGTGCGCGAAGGCGCCGTGGTCGCCTTGGGCACCGGTGATCGCTCGACCCGCCCCGGTCTGGTGGTCGCGGCCGAGTTCCGCGGCCCAGACGAGGCGAACGCCCGCGCCGAACTGATCCAACGCGTTGCGTCCGAGTGCGGTATCGTCCCGTCCGACGTCGTCTTCGTGTCGCCTGGATCACTGCCCCGGACGTCGTCTGGAAAACTGCGCCGCTTGGCAGTCCGGCGCTCCCTGGAGATGGCGGACTGA
- Drug Resistance
- Mutations
- Function
- Activates lipidic moieties required for mycobactin biosynthesis. Converts medium- to long-chain aliphatic fatty acids into acyl adenylate, which is further transferred on to the phosphopantetheine arm of the carrier protein MbtL. {ECO:0000269|PubMed:16461464}.
- Family
-
ATP-dependent AMP-binding enzyme family
- GO
-
- growth of symbiont in host cell GO:0044119 biological_process
- adenylyltransferase activity GO:0070566 molecular_function
- ATP binding GO:0005524 molecular_function
- long-chain fatty acid [acyl-carrier-protein] ligase activity GO:0008922 molecular_function
- fatty acid biosynthetic process GO:0006633 biological_process
- InterPro
Summary
- Name
- Long-chain-fatty-acid--[acyl-carrier-protein] ligase MbtM (EC 6.2.1.20) (Fatty acyl-[acyl-carrier-protein] synthetase) (Fatty acyl-ACP synthetase) (Mycobactin synthetase protein M)
- Family
- ATP-dependent AMP-binding enzyme family
- Protein Sequence
-
MSELAAVLTRSMQASAGDLMVLDRETSLWCRHPWPEVHGLAESVAAWLLDHDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGANDQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAGVTIGDLSTAAHTNRSATPVASEGPAVLQGTAGSTGAPRTAILSPGAVLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLAFVLSAALAGAPLWLAPTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARRVSEVDLGALRVTLNGGEPVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPGIGLLADRVIDGSGAHKHAVLGNPIPGMEVRISCGDQAAGNASREIGEIEIRGASMMAGYLGQQPIDPDDWFATGDLGYLGAGGLVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDRSTRPGLVVAAEFRGPDEANARAELIQRVASECGIVPSDVVFVSPGSLPRTSSGKLRRLAVRRSLEMAD
- Mass
- 53,957 Da
- Length
- 521 Aa
Rv1345 doesn't seem to be a targeted by any drug.
-
-
Fatty acid degradation mtu00071
mtu00071PATHWAY_MAP mtu00071 Fatty acid degradation
-
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- A genetic locus required for iron acquisition in Mycobacterium tuberculosis.
- Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2069-74. doi: 10.1073/pnas.0507924103. Epub 2006 Feb 3.
- Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice.
- Microbiology. 2002 Dec;148(Pt 12):3873-80. doi: 10.1099/00221287-148-12-3873.
- ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.
- Infect Immun. 2002 Jul;70(7):3371-81. doi: 10.1128/iai.70.7.3371-3381.2002.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.