Gene - combatTB X

mbtN

Type: protein_coding
Name: mbtN
Locus Name: Rv1346
Product: Acyl-CoA dehydrogenase MbtN
Functional Category: Lipid metabolism
Location: 1510846..1512006 (+ strand)
Gene Length: 1160 bp
Nucleotides: TGACGGCCGGCTCCGACCTCGACGACTTCCGCGGTTTGCTCGCCAAAGCGTTCGACGAGCGGGTGGTGGCATGGACCGCAGAAGCGGAAGCGCAGGAACGTTTTCCGCGCCAGTTGATCGAACACCTGGGTGTCTGCGGCGTATTCGATGCGAAGTGGGCGACCGACGCCCGTCCCGACGTCGGTAAACTCGTCGAACTCGCTTTCGCGTTGGGCCAGCTGGCCTCTGCCGGCATCGGTGTGGGTGTCAGCTTGCATGACTCGGCGATCGCGATTTTGCGCCGGTTTGGTAAGTCGGACTACTTGCGGGATATCTGCGATCAGGCGATCCGTGGCGCCGCGGTGCTGTGCATCGGAGCCTCGGAGGAGTCCGGCGGATCCGACCTGCAGATCGTCGAAACCGAGATACGGTCCCGTGACGGTGGTTTCGAGGTCCGCGGCGTCAAGAAATTCGTGTCGCTGTCTCCGATCGCCGACCACATCATGGTGGTGGCCCGCAGCGTCGACCACGATCCGACCAGTAGGCACGGCAATGTCGCGGTCGTGGCCGTGCCGGCCGCACAAGTCAGCGTGCAGACCCCCTACCGCAAGGTCGGTGCGGGACCGCTGGATACCGCCGCGGTCTGCATCGACACCTGGGTACCGGCCGATGCACTGGTTGCGCGGGCCGGCACGGGGCTGGCAGCCATCAGTTGGGGACTGGCTCATGAGCGGATGTCGATCGCCGGGCAGATCGCAGCGTCGTGTCAACGGGCGATCGGAATCACCCTGGCCCGCATGATGAGTCGACGTCAGTTCGGTCAGACGCTGTTCGAACACCAGGCGCTGCGGCTGCGTATGGCGGACCTGCAGGCGCGTGTCGATCTGCTGCGGTACGCGCTGCACGGCATCGCTGAACAGGGGAGACTGGAACTGCGCACGGCGGCAGCGGTCAAAGTCACCGCCGCCCGGCTCGGTGAGGAAGTCATCTCCGAATGCATGCACATCTTCGGTGGGGCGGGTTATCTTGTCGACGAAACGACGCTTGGCAAATGGTGGCGGGACATGAAGCTCGCCCGGGTCGGCGGCGGCACCGACGAGGTGCTGTGGGAATTGGTGGCTGCCGGCATGACGCCCGATCACGACGGTTACGCAGCCGTGGTCGGAGCTTCCAAAGCGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Catalyzes the dehydrogenation at the alpha-beta position of ACP-bound acyl chains. This results in the introduction of a double bond in the lipidic chain, which is further transferred to the epsilon-amino group of lysine residue in the mycobactin core by MbtK. {ECO:0000269|PubMed:16461464}.

Family

Acyl-CoA dehydrogenase family

GO

siderophore biosynthetic process from catechol GO:0019540 biological_process
flavin adenine dinucleotide binding GO:0050660 molecular_function
enoyl-[acyl-carrier-protein] reductase activity GO:0016631 molecular_function

InterPro

UniProt: P9WQF9
GenBank: Rv1346
EnsemblBacteria: Rv1346
Mycobrowser: Rv1346

Summary

Name: Acyl-[acyl-carrier-protein] dehydrogenase MbtN (Acyl-ACP dehydrogenase MbtN) (EC 1.3.99.-) (Mycobactin synthase protein N)
Family: Acyl-CoA dehydrogenase family
Protein Sequence: MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLGVCGVFDAKWATDARPDVGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYLRDICDQAIRGAAVLCIGASEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSRHGNVAVVAVPAAQVSVQTPYRKVGAGPLDTAAVCIDTWVPADALVARAGTGLAAISWGLAHERMSIAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQALRLRMADLQARVDLLRYALHGIAEQGRLELRTAAAVKVTAARLGEEVISECMHIFGGAGYLVDETTLGKWWRDMKLARVGGGTDEVLWELVAAGMTPDHDGYAAVVGASKA
Mass: 41,180 Da
Length: 386 Aa

Rv1346 doesn't seem to be a targeted by any drug.

Rv1346 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
A genetic locus required for iron acquisition in Mycobacterium tuberculosis.: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2069-74. doi: 10.1073/pnas.0507924103. Epub 2006 Feb 3.
ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.: Infect Immun. 2002 Jul;70(7):3371-81. doi: 10.1128/iai.70.7.3371-3381.2002.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.